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Imidazoline Receptor

Imidazoline receptor ligands act on the I1, I2 and I3 binding sites for imidazoline compounds. Imidazoline receptors were proposed when clonidine-like compounds were found to lower blood pressure through brainstem sites distinct from α2-adrenergic receptors. I1 sites take part in central blood pressure control, and I2 sites are linked to monoamine oxidase. I3 sites in pancreatic β cells are involved in the regulation of insulin secretion. Moxonidine hydrochloride and rilmenidine phosphate are listed as I1 agonists, and AGN 192403 as an I1 antagonist. Idazoxan hydrochloride blocks α2-adrenergic receptors and binds I2 sites, as does BU226 hydrochloride, while KU14R is an I3 antagonist. Clonidine hydrochloride and guanabenz acetate act mainly at α2-adrenergic receptors and are also listed under Adrenergic Receptors.

1 Item

  • BU226 hydrochloride
    Cat. No.
    A78963
    CAS No.
    1186195-56-1

    BU226 hydrochloride

    BU226 hydrochloride is a selective ligand for imidazoline 2 (I2) receptors, exhibiting a binding affinity with a Ki value of 1.4 nM for I2 receptors and an IC50 of 534.5 nM for I1 receptors. This compound plays a significant role in the investigation of antidepressant mechanisms. Its specificity makes it a valuable tool for research aimed at understanding the neurological effects and therapeutic potential of imidazoline receptor modulation.

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    1 mg
    $25.00
    5 mg
    $60.00
    All 6 sizes

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