AChE

Cat. No.

A78884

CAS No.

2828439-12-7

AChE-IN-83

AChE-IN-83 is a potent acetylcholinesterase (AChE) inhibitor targeting cholinesterases in various biological systems. This compound effectively inhibits the growth and behavior of Aphelenchoides oryzae, a nematode pathogen in rice, demonstrating an LC50 value of 19.0 μg/mL over 48 hours. AChE-IN-83 disrupts the nematode cuticle, promoting the accumulation of reactive oxygen species, lipofuscin, and lipids, thereby offering applications in nematode management and enhancing rice seed health.

Cat. No.

A78885

CAS No.

209394-29-6

(S)-Ladostigil

Synonyms: TV-3279

(S)-Ladostigil is a cholinesterase (ChE) inhibitor known for its neuroprotective properties. While it exhibits limited inhibition of monoamine oxidase B (MAO-B), its primary mechanism enhances cholinergic neurotransmission, making it of interest in the study of neurodegenerative disorders. This compound is utilized in research focusing on Alzheimer's disease and other conditions where cholinergic dysfunction is implicated.

Cat. No.

A78886

CAS No.

1079-33-0

Mobam

Mobam is a cholinesterase inhibitor with significant efficacy against Anoplura Pediculidae. This compound effectively reduces cholinesterase (ChE) levels in plasma, erythrocytes, and brain tissue of rat models, leading to suppressed avoidance behavior. Mobam is primarily utilized in toxicological research and studies focused on neurological effects and insecticidal applications.

Cat. No.

A78888

CAS No.

159325-23-2

SZ1676

SZ1676 is a cholinesterase (ChE) inhibitor that functions primarily by blocking the enzymatic activity of acetylcholinesterase. This compound demonstrates significant potential in studying neuromuscular transmission and related disorders. Its biological activity may support research in pharmacology and toxicology, particularly concerning neuromuscular blocking agents and their therapeutic implications.

Cat. No.

A79007

CAS No.

1253978-24-3

MAO-B-IN-2

MAO-B-IN-2 is a selective and competitive inhibitor of monoamine oxidase B (MAO-B) with an IC50 value of 0.51 μM, and it also inhibits butyrylcholinesterase (BChE) with an IC50 of 7.00 μM. This compound plays a significant role in studying neurodegenerative disorders by modulating monoamine metabolism, making it valuable for research into conditions such as Parkinson's disease and Alzheimer's disease. Its specificity for MAO-B makes it an important tool for exploring therapeutic pathways involving neurotransmitter regulation.

Cat. No.

A79621

CAS No.

202337-44-8

6-O-p-Hydroxybenzoylglutinoside

6-O-p-Hydroxybenzoylglutinoside is a selective NF-κB inhibitor that effectively suppresses TNF-α-activated NF-κB transcriptional activity, with an IC50 of 52.78 μM. This compound demonstrates targeted biological activity without significantly inhibiting soluble epoxide hydrolase (sEH), acetylcholinesterase (AChE), or butyrylcholinesterase (BChE). Isolated from the seeds of Catalpa bungei (Manchurian catalpa), 6-O-p-Hydroxybenzoylglutinoside is valuable for research applications focused on inflammation and signal transduction pathways.

Cat. No.

A87792

CAS No.

7461-50-9

4-Amino-2-chloropyrimidine

4-Amino-2-chloropyrimidine is a pyrimidine derivative that acts as a competitive inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with inhibition constants (Ki) of 0.18 μM and 1.324 μM, respectively. This compound effectively occupies the binding pocket of the 4BDS structure. Additionally, 4-Amino-2-chloropyrimidine demonstrates potent inhibitory activity against glutathione S-transferase (GST) with an IC50 value of 0.037 μM and a Ki of 0.047 μM. Its biochemical activity makes it a valuable reagent for research in enzyme inhibition and neurochemical studies.

Cat. No.

A89178

CAS No.

506-52-5

1-Hexacosanol

Synonyms: Ceryl Alcohol

1-Hexacosanol is an inhibitor of acetylcholinesterase (AChE), primarily targeting this enzyme to modulate neurochemical activity. It exhibits larvicidal effects, demonstrating the ability to inhibit AChE activity in species such as Culex quinquefasciatus, Aedes aegypti, and Chironomus riparius. This compound is valuable for research applications in neurotoxicology and pest management studies.

Cat. No.

A90657

CAS No.

159954-34-4

6-Chloro-3-indoxyl butyrate

6-Chloro-3-indoxyl butyrate is a biochemical assay reagent primarily employed for the detection and quantification of butyrylcholinesterase activity. This compound serves as a chromogenic substrate, producing a measurable color change upon hydrolysis, which facilitates the assessment of enzyme kinetics in various biological samples. Its application extends to enzyme activity studies, screening for inhibitors, and research in neurobiology and toxicology.

Cat. No.

A97141

CAS No.

30614-22-3

Pirimicarb-desmethyl

Pirimicarb-desmethyl is a key metabolite of the carbamate insecticide pirimicarb, functioning primarily through the inhibition of acetylcholinesterase activity. This compound offers valuable insights into the metabolic pathways of pirimicarb and can be used to study its environmental persistence and toxicological effects. Its application is important in both agricultural research and the assessment of pesticide safety.

Cat. No.

B11539

CAS No.

2463-84-5

Isochlorthion

Synonyms: OMS 214; Dicapthon; ENT 17035

Isochlorothion is an organic phosphorus pesticide that acts primarily through the inhibition of acetylcholinesterase, leading to increased levels of acetylcholine in synaptic clefts. This mechanism results in heightened neurotoxicity, making it effective in agricultural applications for pest control. Isochlorothion is commonly utilized in research to study the effects of organophosphates on environmental systems and human health.

Cat. No.

B11596

CAS No.

96182-53-5

Tebupirimfos

Tebupirimfos is a potent insecticide that acts as an acetylcholinesterase inhibitor, disrupting neurotransmission in insects. Its primary mechanism involves the irreversible inhibition of the enzyme, leading to paralysis and death in targeted pest species. Tebupirimfos is commonly utilized in agricultural applications to manage various insect populations effectively, ensuring crop protection and yield stability.

Cat. No.

B11603

CAS No.

6552-21-2

Fensulfothion oxon

Fensulfothion oxon is a pesticide characterized by its sulfoxide group, which acts as a potent inhibitor of acetylcholinesterase. This inhibition disrupts the normal breakdown of acetylcholine, leading to increased neurotransmitter levels and subsequent toxic effects on target pests. Its primary applications include agricultural pest control and research into the mechanisms of pesticide action and environmental impact.

Cat. No.

B19623

CAS No.

1162-10-3

Buphanidrine

Buphanidrine is an acetylcholinesterase (AChE) inhibitor with an IC50 of 52.8 μM. This compound, isolated from Brunsvigia josephinae, demonstrates significant potential in the study of neurodegenerative diseases, particularly Alzheimer's disease. Its ability to modulate cholinergic signaling makes it a valuable tool for understanding the pathophysiology of cognitive decline and exploring therapeutic strategies.

Cat. No.

B20557

CAS No.

62850-32-2

Fenothiocarb

Synonyms: Phenothiocarb

Fenothiocarb is a carbamate insecticide that functions as a potent acetylcholinesterase inhibitor. It exhibits biological activity by disrupting the normal function of the nervous system in target insects, leading to paralysis and death. This compound is primarily utilized in research focused on pesticide residue analysis and environmental monitoring of agrochemicals. Its role in studying the impact of pesticide exposure on ecosystems and non-target organisms makes it a valuable tool in toxicological assessments.

Cat. No.

B21315

CAS No.

577-85-5

Flavonol

Flavonol is a cholinesterase (ChE) inhibitor, demonstrating an IC50 of 120 μM and a Ki value of 74 μM. This compound exhibits notable antioxidant, free radical-scavenging, and antibacterial activities, while also modulating immune responses. Flavonol effectively inhibits the PriA helicase in Staphylococcus aureus and reduces nitric oxide (NO) production in LPS-activated RAW 264.7 cells by downregulating iNOS expression. Its protective and analgesic effects in murine models suggest potential applications in research focused on tumors and atherosclerosis.

Cat. No.

B21397

CAS No.

115-79-7

Ambenonium chloride

Synonyms: WIN 8077 chloride

Ambenonium chloride is a potent, reversible inhibitor of acetylcholinesterase (AChE), demonstrating a high affinity for the enzyme. With an IC50 value of 0.7 nM for human AChE, this compound effectively enhances cholinergic transmission. It is primarily utilized in research applications focused on neurological disorders, particularly those involving impaired cholinergic function.

Cat. No.

B21681

CAS No.

303-54-8

Depramine

Synonyms: GP 31406

Depramine, a tricyclic antidepressant, primarily targets neurotransmitter reuptake mechanisms, elevating levels of norepinephrine and serotonin in the synaptic cleft. It exhibits significant biological activity through the inhibition of acetylcholinesterase, Mg2+-ATPase, and Na+/K+ ATPase. Depramine is utilized in research focused on depression and related mood disorders, facilitating studies on neurotransmitter dynamics and cellular signaling pathways involved in antidepressant efficacy.

Cat. No.

B21732

CAS No.

602-09-5

1,1'-Bi-2-naphthol

1,1'-Bi-2-naphthol is a potent acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 21.9 μM against human AChE. This compound also exhibits cytotoxic effects on Artemia nauplii, making it valuable for studies in neuropharmacology and toxicology. Its dual functionality positions it as a useful reagent in researching cholinergic signaling and the potential effects of AChE inhibition.

Cat. No.

B21803

CAS No.

57-47-6

Physostigmine

Synonyms: Eserine

Physostigmine, a reversible acetylcholinesterase (AChE) inhibitor, effectively increases acetylcholine levels in the central nervous system by crossing the blood-brain barrier. This compound enhances cholinergic neurotransmission and has been shown to reverse memory deficits in transgenic mice models of Alzheimer's disease. Additionally, Physostigmine serves as a critical antidote for anticholinergic poisoning, providing valuable insights for neuropharmacological research and therapeutic applications.

Cat. No.

B21892

CAS No.

2497-06-5

Disulfoton sulfone

Disulfoton sulfone is a metabolic byproduct of the organophosphorus pesticide Disulfoton, primarily targeting acetylcholinesterase. This compound exhibits significant biological activity as an inhibitor of cholinesterase, which can lead to increased levels of acetylcholine at synapses. Researchers utilize Disulfoton sulfone in studies focused on neurotoxicity, pesticide metabolism, and mechanisms of organophosphate toxicity, contributing to our understanding of their effects on human health and the environment.