AChE

Cat. No.

A78770

CAS No.

315210-31-2

MAO-A/B-IN-3

MAO-A/B-IN-3 is a dual inhibitor targeting both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), as well as acetylcholinesterase (AChE). With IC50 values of 67 nM for MAO-A, 29 nM for MAO-B, and 1370 nM for AChE, this compound demonstrates substantial multi-target efficacy. MAO-A/B-IN-3 modifies key binding sites to enhance its inhibitory activity against MAO enzymes while reducing the impact on AChE. This reagent is particularly relevant for research focused on neurodegenerative disorders.

Cat. No.

A78771

CAS No.

120012-04-6

Dihydro Donepezil

Synonyms: Dihydro E2020

Dihydro Donepezil is a potent cholinesterase (ChE) inhibitor, serving as a metabolite of Donepezil. It demonstrates significant biological activity, inhibiting acetylcholinesterase with IC50 values of 8.12 nM for bovine acetylcholinesterase (bAChE) and 11.6 nM for human acetylcholinesterase (hAChE). This compound is primarily utilized in research focused on neurodegenerative disorders and cognitive enhancement, contributing to studies on Alzheimer's disease and related pathways.

Cat. No.

A78772

CAS No.

2214210-63-4

AChE-IN-52

AChE-IN-52 is an acetylcholinesterase (AChE) inhibitor that demonstrates notable antitumor activity, particularly against breast cancer MCF-7 cells. This compound significantly disrupts amino acid metabolism and inhibits the migration of MCF-7 cells. Furthermore, AChE-IN-52 exerts its anticancer effects through the regulation of Best1 and HIST1H2BJ, making it a valuable tool for research in cancer biology and therapeutic development.

Cat. No.

A78774

CAS No.

6266-40-6

1,10-Bis(pyridinium)decane

Synonyms: Decamethylenebispyridinium dibromide

1,10-Bis(pyridinium)decane is a biscationic compound that acts as an acetylcholinesterase (AchE) inhibitor, demonstrating an IC50 of 25.8 nM. This reagent is valuable for research focused on neuropharmacology and the modulation of cholinergic signaling. Its specificity for AchE makes it suitable for studies investigating cognitive function and neurodegenerative diseases.

Cat. No.

A78776

CAS No.

412044-92-9

Ganstigmine hydrochloride

Synonyms: CHF 2819

Ganstigmine hydrochloride is an orally active inhibitor of acetylcholinesterase (AChE) that enhances the release of soluble amyloid precursor protein alpha (sAPPα) from neuroblastoma cells. This compound has been shown to increase acetylcholine levels in the prefrontal cortex of rats, making it a valuable tool in the study of cholinergic signaling. Ganstigmine hydrochloride is primarily utilized in research focused on neurological disorders, particularly Alzheimer's disease, to explore its implications in cognitive function and neuroprotection.

Cat. No.

A78777

CAS No.

2700896-73-5

BChE-IN-13

BChE-IN-13 is a potent and selective inhibitor of Butyrylcholinesterase (BChE), targeting both equine and human forms with IC50 values of 0.22 μM and 0.016 μM, respectively. This orally active compound demonstrates significant potential for enhancing memory and cognitive functions, making it a valuable tool in Alzheimer's disease research. Its specificity for BChE positions it as a promising candidate for exploring therapeutic strategies in neurodegenerative disorders.

Cat. No.

A78778

CAS No.

2410992-69-5

AChE/BChE-IN-3 hydrochloride

AChE/BChE-IN-3 hydrochloride is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 6.08 μM against electric eel AChE and 0.383 μM against equine serum BChE. This compound is valuable for research focused on neurodegenerative diseases and cholinergic dysfunction, providing insights into the modulation of cholinergic signaling pathways. Its potent inhibitory effects make it a useful tool for studying enzyme kinetics and drug discovery related to cognitive decline.

Cat. No.

A78779

CAS No.

145508-78-7

Icopezil

Synonyms: CP-118,954

Icopezil is a selective inhibitor of acetylcholinesterase (AchE), a key enzyme involved in the hydrolysis of acetylcholine. Its ability to enhance cholinergic transmission makes it a valuable compound for research in Alzheimer's disease and other cognitive disorders. By increasing acetylcholine levels in the synaptic cleft, Icopezil offers potential insights into therapeutic strategies targeting cholinergic deficits in neurodegenerative conditions.

Cat. No.

A78781

CAS No.

215319-47-4

(+)-Balanophonin (d-Balanophonin)

Synonyms: d-Balanophonin

(+)-Balanophonin is a phenolic compound that functions as an inhibitor of cholinesterase (ChE). It exhibits significant biological activities, including antioxidant, anti-inflammatory, anticancer, and antineurodegenerative effects. This compound is useful in research aimed at understanding neurodegenerative diseases and exploring potential therapeutic strategies for conditions associated with cholinergic system dysfunction.

Cat. No.

A78782

CAS No.

2185837-61-8

BChE-IN-10

BChE-IN-10 is a potent mixed-type inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 value of 6.4 μM. Isolated from Bletilla striata, this compound effectively modulates cholinergic activity and holds potential in the investigation of Alzheimer’s disease (AD) pathology. Its application in neurodegenerative research makes it a valuable tool for studying BChE-related mechanisms and therapeutic strategies.

Cat. No.

A78784

CAS No.

67600-94-6

Hydrangenol 8-O-glucoside

Synonyms: Hydrangenol 8-O-β-D-glucopyranoside

Hydrangenol 8-O-glucoside is an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 22.66 μM. Isolated from Hydrangea macrophyllus, this compound exhibits significant activity in inhibiting the PCA (passive cutaneous anaphylaxis) reaction. Its properties make it a useful tool for research on neurodegenerative diseases and allergic responses.

Cat. No.

A78785

CAS No.

2653349-51-8

S16–1029

S16–1029 is a selective and orally active butyrylcholinesterase (BChE) inhibitor, exhibiting IC50 values of 11.35 nM for equine BChE and 48.1 nM for human BChE. This compound is capable of crossing the blood-brain barrier (BBB), enabling it to effectively target the central nervous system (CNS). S16–1029 serves as a valuable tool for research in Alzheimer's disease (AD), contributing to the understanding of cholinergic dysfunction in neurodegenerative conditions.

Cat. No.

A78786

CAS No.

2700896-78-0

BChE-IN-14

BChE-IN-14 is a selective butyrylcholinesterase (BChE) inhibitor, demonstrating IC50 values of 0.23 μM for equine BChE and 0.011 μM for human BChE. This compound exhibits favorable blood-brain barrier permeability and primary cell safety, making it suitable for in vivo studies. BChE-IN-14 has potential in restoring cognitive function, positioning it as a valuable tool for research into Alzheimer’s disease and related neurodegenerative conditions.

Cat. No.

A78789

CAS No.

180694-97-7

Mimopezil

Synonyms: ZT-1

Mimopezil is a cholinesterase (ChE) inhibitor that converts to the active metabolite Huperzine A in aqueous conditions. This compound demonstrates significant biological activity by enhancing acetylcholine levels, which is relevant in research focused on neurodegenerative diseases. Although Mimopezil exhibits low bioavailability in vivo, its effective metabolism to Huperzine A leads to increased concentrations in the bloodstream, making it a valuable tool for studying cognitive function and synaptic transmission.

Cat. No.

A78790

CAS No.

126594-75-0

(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol

(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol is an acetylcholinesterase (AChE) inhibitor. At a concentration of 100 μg/mL, this compound demonstrates an in vitro inhibition rate of 12% against AChE, highlighting its potential utility in studies related to neurodegenerative diseases and cognitive disorders. Its application in biochemical research may provide insights into AChE-related pathways and therapeutic targets.

Cat. No.

A78791

CAS No.

1607436-76-9

Monardic acid A

Monardic acid A is a selective inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 of 53.1 μM against AChE from electric eel. It displays weak inhibitory activity against human erythrocyte AChE (IC50 >100 μM) and negligible effects on butyrylcholinesterase (BChE). By inhibiting AChE activity, Monardic acid A effectively reduces acetylcholine breakdown, contributing to its anti-inflammatory properties and modulation of neurotransmitter release. This compound is sourced from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), making it valuable for research in anti-inflammatory drug development and neurodegenerative disease therapeutics.

Cat. No.

A78793

CAS No.

1679-76-1

Drofenine

Synonyms: Cycloadiphene; Hexahydroadiphenine

Drofenine is a potent competitive inhibitor of cholinesterase (ChE), with a Ki value of 3 μM. This compound effectively inhibits the breakdown of acetylcholine, leading to increased levels of this important neurotransmitter. Drofenine is utilized in research to study cholinergic signaling and its implications in neurodegenerative diseases, as well as to explore potential therapeutic avenues for conditions associated with impaired cholinergic transmission.

Cat. No.

A78796

CAS No.

2020357-32-6

BChE-IN-23

BChE-IN-23 is a potent butyrylcholinesterase (BChE) inhibitor with an IC50 value of 21 nM. This compound is particularly valuable in Alzheimer's disease research, facilitating the study of cholinergic dysfunction associated with neurodegenerative conditions. Its selective inhibition of BChE may contribute to the development of therapeutic strategies for cognitive impairments in Alzheimer's disease.

Cat. No.

A78797

CAS No.

2499490-52-5

BuChE-IN-4

BuChE-IN-4 is a selective butyrylcholinesterase (BuChE) inhibitor with an IC50 of 7.7 nM. It demonstrates mild antioxidant properties and neuroprotective effects while exhibiting a favorable lipophilicity and low toxicity profile. This compound is applicable in research focused on neurodegenerative diseases and exploring cholinergic signaling pathways.

Cat. No.

A78798

CAS No.

3811-49-2

Salithion

Synonyms: Dioxabenzofos

Salithion is an acetylcholinesterase inhibitor that disrupts the hydrolysis of acetylcholine by binding to the enzyme's active site. This compound exhibits enantioselectivity, with distinct differences in the biological activity of its (R) and (S) enantiomers. Salithion serves as a valuable tool in neurotoxicology research and studies related to cholinergic signaling pathways.

Cat. No.

A78799

CAS No.

2713548-95-7

AChE-IN-3

AChE-IN-3 is a cholinesterase (ChE) inhibitor that demonstrates moderate inhibitory activity against acetylcholinesterase (AChE). Additionally, it exhibits strong nitric oxide (NO) inhibitory activity with an EC50 of 0.57 μM. This compound is suitable for research applications focused on neurodegenerative diseases and signaling pathways involving nitric oxide.

Cat. No.

A78800

CAS No.

113027-75-1

AChE-IN-103

AChE-IN-103 is a potent acetylcholinesterase (AChE) inhibitor that demonstrates log IC50 values of 1.477 and 2.2 in alignment models I and II, respectively. This compound plays a significant role in the research of Alzheimer’s disease, where it may help elucidate the mechanisms of cholinergic dysfunction. AChE-IN-103 is valuable for studies aimed at developing therapeutic strategies targeting cognitive decline associated with this neurodegenerative disorder.

Cat. No.

A78801

CAS No.

30426-66-5

Pseudocoptisine acetate

Synonyms: Isocoptisine acetate

Pseudocoptisine acetate is a quaternary alkaloid derived from the benzylisoquinoline scaffold, isolated from Corydalis Tuber. It functions as an acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 of 12.8 μM. This compound demonstrates significant anti-inflammatory and anti-amnestic properties, making it valuable for research in neurodegenerative diseases and cognitive impairment studies.

Cat. No.

A78802

CAS No.

129297-21-8

SM 10888

SM 10888 is a selective and orally active cholinesterase (ChE) inhibitor. By enhancing the release of acetylcholine in the brain, SM 10888 offers potential therapeutic benefits in the context of neurological disorders. This compound is particularly relevant for research focused on Alzheimer's disease and other cholinergic dysfunctions.

Cat. No.

A78803

CAS No.

2215768-12-8

BChE-IN-34

BChE-IN-34 is a highly selective inhibitor of butyrylcholinesterase (BChE) with an IIC50 of 25 nM, demonstrating excellent selectivity over acetylcholinesterase. This compound exhibits neuroprotective and antioxidant properties, making it a valuable tool for research into neurodegenerative diseases and cholinergic signaling pathways. Its specificity and efficacy position BChE-IN-34 as a promising candidate for studying the therapeutic potential of targeting BChE in various biological contexts.