AChE

Cat. No.

A78839

CAS No.

2528-36-1

Dibutyl phenyl phosphate

Dibutyl phenyl phosphate acts primarily as a flame retardant, with additional activity as a butyrylcholinesterase (BChE) inhibitor, exhibiting an IC50 value of 83.6 μM and a Ki of 94.5 μM. Its chemical structure contributes to its efficacy in enhancing fire safety in various materials. This compound is useful for research applications in the fields of material science and neurobiology, exploring both flame retardant properties and enzymatic inhibition.

Cat. No.

A78840

CAS No.

302-40-9

Benactyzine

Benactyzine is a competitive inhibitor of butyrylcholinesterase (BChE) with a Ki value of 0.01 mM. This anticholinergic agent exhibits significant biological activity by blocking cholinergic transmission, making it relevant in studies related to neurological disorders and organophosphate poisoning. Benactyzine is a valuable tool for research applications focused on cholinergic receptor pathways and the effects of anticholinergic compounds.

Cat. No.

A78841

CAS No.

386211-69-4

Quinolactacin A2

Quinolactacin A2 is an acetylcholinesterase inhibitor that effectively reduces the breakdown of acetylcholine, thereby enhancing cholinergic neurotransmission. Additionally, this compound has been shown to inhibit tumor necrosis factor (TNF) production, which may have implications in inflammatory and neurodegenerative research. Quinolactacin A2 is valuable in studies investigating cholinergic signalling and its role in various pathophysiological conditions.

Cat. No.

A78843

CAS No.

182068-83-3

Arisugacin B

Arisugacin B is a selective acetylcholinesterase (AChE) inhibitor with potent oral bioactivity. Its mechanism of action involves the inhibition of AChE, which plays a crucial role in neurotransmission by regulating acetylcholine levels. This compound is useful in research applications focused on neurodegeneration and related disorders, offering insights into potential therapeutic strategies for conditions such as Alzheimer's disease.

Cat. No.

A78845

CAS No.

1011351-65-7

AE027

AE027 is a potent inhibitor of acetylcholinesterase (AChE), effectively targeting both wild-type and the resistant F348Y mutation, with IC50 values of 10 μM and 43 μM, respectively. This compound exhibits significant biological activity in blocking AChE, making it a valuable tool for research in neurodegenerative disorders and studies related to cholinergic signaling. AE027 provides potential insights into therapeutic strategies for conditions associated with AChE dysregulation.

Cat. No.

A78846

CAS No.

6882-09-3

Undulatine

Undulatine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 7.4 μM. This compound is capable of crossing the blood-brain barrier through passive permeation, making it a valuable tool for investigating the pathophysiology of Alzheimer's disease. Its ability to modulate cholinergic activity positions Undulatine as a promising candidate for research into therapeutic strategies for neurodegenerative disorders.

Cat. No.

A78847

CAS No.

86537-66-8

N-Methylcalycinine

N-Methylcalycinine is a natural product that acts as an acetylcholinesterase (AChE) inhibitor. Isolated from the roots of Stephania epigaea, it possesses potential therapeutic implications in various research fields, including asthma, cancer, dysentery, fever, hyperglycemia, intestinal disorders, inflammation, sleep disturbances, and tuberculosis. This compound may be valuable for studies exploring its effects on neurotransmitter regulation and related biological processes.

Cat. No.

A78848

CAS No.

360768-68-9

Samioside

Samioside is an acetylcholinesterase inhibitor primarily extracted from the plants Phlomis nissolii and P. capitata. It exhibits notable free-radical scavenging and antimicrobial properties, making it a valuable compound for biological research. Samioside is particularly relevant for studies investigating its potential anti-Alzheimer’s effects, offering insights into therapeutic avenues for neurodegenerative conditions.

Cat. No.

A78851

CAS No.

390362-51-3

Buxbodine B

Buxbodine B is an acetylcholinesterase (AChE) inhibitor with an IC50 of 50 μM. It demonstrates significant potential in the study of neurodegenerative diseases, particularly Alzheimer's disease, by modulating cholinergic transmission. Its inhibitory action on AChE facilitates the exploration of therapeutic strategies aimed at enhancing cognitive function and memory retention in affected populations.

Cat. No.

A78852

CAS No.

261950-94-1

Arisugacin D

Arisugacin D is an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 3.5 μM. This compound is notable for its potential to enhance synaptic acetylcholine levels, making it useful in studies related to neurodegenerative diseases such as Alzheimer's. The inhibition of AChE facilitates the investigation of cholinergic signaling pathways and the development of therapeutic strategies targeting cognitive decline.

Cat. No.

A78854

CAS No.

2270876-07-6

AL284

AL284 is a potent inhibitor of Anopheles gambiae acetylcholinesterase 1 (AgAChE1), targeting key residues Tyr489Ag and Trp441Ag within the enzyme structure. This compound demonstrates significant biological activity in disrupting neurotransmitter breakdown, which is critical for the survival of disease-transmitting mosquitoes. AL284 is valuable for research applications focused on controlling mosquito populations and studying vector-borne diseases.

Cat. No.

A78855

CAS No.

588-17-0

Neostigmine hydroxide

Neostigmine hydroxide is a potent cholinesterase inhibitor that enhances acetylcholine levels at neuromuscular junctions. This compound is primarily utilized in research related to myasthenia gravis and other neuromuscular disorders, aiding in the exploration of muscular function and neuropharmacology. Its ability to counteract muscle weakness makes it a valuable tool for studying therapeutic interventions in cholinergic signaling.

Cat. No.

A78856

CAS No.

321-54-0

Coroxon

Synonyms: Coumaphos oxon

Coroxon, an AChE inhibitor, is an oxidative metabolite of the organophosphate insecticide Coumaphos. This compound exhibits significant insecticidal and acaricidal activity, making it valuable for pest control research. Additionally, Coroxon can be hydrolyzed by phosphotriesterases from microorganisms such as Nocardia asteroides, resulting in the production of the fluorescent compound Chlorferon, which can be utilized in biochemical assays and studies related to enzyme activity.

Cat. No.

A78858

CAS No.

444179-57-1

Salvianolic acid H

Salvianolic acid H is a potent inhibitor of acetylcholinesterase (AChE), serving to enhance cholinergic neurotransmission. Its primary biological activity includes the potential modulation of neurodegenerative processes associated with cognitive decline. This compound is valuable for research applications aimed at understanding Alzheimer's disease and other conditions linked to cholinergic deficits.

Cat. No.

A78860

CAS No.

5778-80-3

7-Methoxytacrine

Synonyms: 7-MEOTA

7-Methoxytacrine is a potent inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM. This compound is utilized in research related to Alzheimer's disease, highlighting its potential role in modulating neurotransmitter levels and improving cognitive function. Its mechanism of action makes it a valuable tool for investigating therapeutic strategies in neurodegenerative disorders.

Cat. No.

A78865

CAS No.

20316-18-1

Lycodine

Lycodine is a lycopodium alkaloid that acts as a cholinesterase inhibitor. It demonstrates significant anticholinesterase activity, making it a valuable tool for research into neurological disorders and cognitive function. Its potential applications extend to studying mechanisms of acetylcholine modulation and developing therapeutic approaches for conditions such as Alzheimer’s disease.

Cat. No.

A78866

CAS No.

52179-44-9

Graphislactone A

Graphislactone A is an acetylcholinesterase (AChE) inhibitor, which demonstrates significant potential in the investigation of neurodegenerative diseases. With an IC50 value of 27 μM, it effectively inhibits AChE activity, contributing to enhanced cholinergic signaling. Additionally, Graphislactone A exhibits antioxidant properties, making it a valuable compound for research focused on oxidative stress-related disorders.

Cat. No.

A78867

CAS No.

432-68-8

Echinenone

Echinenone acts as an acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 value of 16.29 μg/mL. This compound demonstrates anti-Aβ(25-35) activity and has been shown to decrease malondialdehyde (MDA) levels while enhancing the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). These properties indicate its potential use in research focused on neuroprotection and alleviating oxidative stress-related damage.

Cat. No.

A78870

CAS No.

3344-11-4

Isodimethoate

Isodimethoate is an acetylcholinesterase (AChE) inhibitor that demonstrates potent anticholinesterase activity. As a thermal decomposition product of Dimethoate, it effectively inhibits AChE in human red blood cells, making it valuable for studying cholinergic signaling and related neurochemical pathways. This compound is frequently utilized in research focused on neurotoxicology and the effects of organophosphates on enzymatic activity.

Cat. No.

A78872

CAS No.

40626-35-5

Heterophos

Synonyms: Heterofos

Heterophos is an organophosphorus insecticide that functions as an acetylcholinesterase (AChE) inhibitor. By disrupting the normal breakdown of acetylcholine, Heterophos leads to the accumulation of this neurotransmitter, resulting in disturbances of nerve conduction in insects. This mechanism underpins its efficacy in pest control applications, particularly in the study of insect neurophysiology and insecticide resistance mechanisms.

Cat. No.

A78873

CAS No.

31049-08-8

Dihydrokaempferol-3-O-β-D-glucoside

Dihydrokaempferol-3-O-β-D-glucoside is a natural product that acts as an inhibitor of acetylcholinesterase (AChE). Isolated from the bark of Cudrania tricuspidata, this compound demonstrates potential biological activity in modulating cholinergic signaling. Its research applications include studies on neurodegenerative diseases and exploration of cognitive enhancement mechanisms.

Cat. No.

A78875

CAS No.

488-42-6

Galactamine

Galactamine is an acetylcholinesterase (AChE) inhibitor that plays a crucial role in modulating neurotransmitter levels by preventing the breakdown of acetylcholine. This compound is primarily utilized in research investigating Alzheimer's disease and other neurodegenerative disorders, where it helps to elucidate the mechanisms underlying cognitive decline and potential therapeutic strategies. Galactamine's ability to enhance cholinergic signaling makes it a valuable tool in the study of efficacy and safety in neuropharmacology.

Cat. No.

A78876

CAS No.

69567-11-9

Deoxynojirimycin tetrabenzyl ether

Deoxynojirimycin tetrabenzyl ether is an inhibitor of human butyrylcholinesterase (hBuChE), with an IC50 value of 2.0 μM. This compound is utilized in research focused on neurological disorders and cholinergic system regulation, making it valuable for studies involving enzyme inhibition and potential therapeutic applications in cognitive decline.

Cat. No.

A78882

CAS No.

261950-90-7

Arisugacin C

Arisugacin C is an acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 2.5 μM, demonstrating its potent activity in modulating cholinergic neurotransmission. This compound is valuable for research into neurodegenerative diseases, including Alzheimer’s disease, where AChE inhibition may alleviate cognitive decline. Its selectivity and efficacy make it a useful tool in studying the mechanisms of cholinergic signaling and developing potential therapeutic strategies.

Cat. No.

A78883

CAS No.

956-04-7

4-Chlorochalcone

4-Chlorochalcone is a selective monoamine oxidase inhibitor, demonstrating an IC50 of 0.082 μM against hMAO-B and 9.95 μM against hMAO-A. This compound also shows inhibitory activity towards acetylcholinesterase, with an IC50 of 2.79 μM. As a chalcone derivative, 4-Chlorochalcone is valuable for research focused on neurodegenerative diseases and the modulation of neurotransmitter levels.