AChE

Cat. No.

A10006

CAS No.

102518-79-6

(-)-Huperzine A

(-)-Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata.

Cat. No.

A10330

CAS No.

120011-70-3

Donepezil hydrochloride

Donepezil is a centrally acting reversible acetylcholinesterase inhibitor.

Cat. No.

A10416

CAS No.

1953-04-4

Galanthamine hydrobromide

Synonyms: Reminyl

Galanthamine is an AChE inhibitor with IC50 of 14 nM.

Cat. No.

A10635

CAS No.

114-80-7

Neostigmine bromide (Prostigmin)

Synonyms: Vagostigmin; Prostigmin

Neostigmine bromide is a reversible acetylcholine esterase inhibitor that binds to the anionic binding site of AChE.

Cat. No.

A10762

CAS No.

101-26-8

Pyridostigmine bromide

Pyridostigmine bromide is an orally active cholinesterase (ChE) inhibitor that enhances acetylcholine levels by inhibiting the enzyme responsible for its breakdown. This compound demonstrates significant biological activity in modulating cholinergic signaling, making it useful in studying neurodegenerative disorders and neuromuscular junction diseases. Its applications extend to cardiovascular disease research, where it can elucidate cholinergic mechanisms underlying cardiac function and dysfunction.

Cat. No.

A11719

CAS No.

129101-54-8

Rivastigmine tartrate

Synonyms: Exelon

Rivastigmine tartrate is a dual cholinesterase inhibitor (ChEI). It inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE).

Cat. No.

A12483

CAS No.

357-70-0

Galanthamine

Synonyms: Galantamine

Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

Cat. No.

A13079

CAS No.

120014-06-4

Donepezil

Donepezil is a noncompetitive acetylcholineesterase inhibitor, which can readily cross the blood brain barrier and increase the concentration of cortical acetylcholine. It is known that Donepezil is a useful tool in the study of Alzheimer's disease.

Cat. No.

A13925

CAS No.

61939-05-7

Deoxyvasicine HCl

Synonyms: Pegene hydrochloride; Vasicine

Desoxypeganine hydrochloride is an AChE (acetylcholinesterase) inhibitor that has been used in the treatment of Alzheimer's dementia.

Cat. No.

A14096

CAS No.

123441-03-2

Rivastigmine

Synonyms: S-Rivastigmine

Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase.

Cat. No.

A14353

CAS No.

89-82-7

Pulegone

Synonyms: (+)-Pulegone

Pulegone is a monoterpene compound found in a number of essential oils. The unit of Product is ml.

Cat. No.

A14590

CAS No.

18797-79-0

(+)-Corynoline

(+)-Corynoline is an acetylcholinesterase inhibitor isolated from Corydalis incisa.

Cat. No.

A15629

CAS No.

24502-78-1

Acetylshikonin

Acetylshikonin is a potent anti-inflammatory agent that also functions as an inhibitor of acetylcholinesterase (AChE) and non-selective cytochrome P450 enzymes. With an IC50 of 34.6 μM for AChE, Acetylshikonin exhibits neuroprotective properties and can induce apoptosis and autophagy in cancer cells. Its ability to regulate blood glucose and liver fat metabolism makes it valuable in research related to diabetes, diabetic nephropathy, obesity, and nonalcoholic fatty liver disease.

Cat. No.

A15678

CAS No.

518-69-4

Corydaline

Synonyms: (+)-Corydaline; Corydalin

Corydaline is an isoquinoline alkaloid that functions as a cholinesterase (ChE) inhibitor with an IC50 of 226 μM. In addition to its cholinergic activity, Corydaline acts as a μ-opioid receptor agonist (Ki of 1.23 μM) and demonstrates significant antiviral effects by inhibiting enterovirus 71 (EV71) replication, with an IC50 of 25.23 μM. This compound also exhibits anti-angiogenic, anti-allergic, gastric-emptying, and antinociceptive properties, making it a valuable reagent for various biological research applications.

Cat. No.

A15722

CAS No.

7431-77-8

Sinapine thiocyanate

Sinapine thiocyanate is a cholinesterase (ChE) inhibitor known for its multifaceted biological activities. This alkaloid, derived from cruciferous plant seeds, exhibits anti-inflammatory, antioxidant, antitumor, anti-angiogenic, and radioprotective properties. Its ability to inhibit acetylcholinesterase (AChE) highlights its potential in research related to neurodegenerative disorders such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

Cat. No.

A15748

CAS No.

92-61-5

Scopoletin

Synonyms: Gelseminic acid; Chrysatropic acid

Scopoletin is a cholinesterase inhibitor that primarily targets acetylcholinesterase (AChE). It possesses notable biological activity in preventing the breakdown of acetylcholine, thereby enhancing cholinergic transmission. Scopoletin is commonly used in research focused on neurodegenerative diseases, cognitive disorders, and potential therapeutic interventions involving cholinergic systems.

Cat. No.

A15782

CAS No.

773092-05-0

Acotiamide hydrochloride trihydrate

Synonyms: YM-443; Z-338

Acotiamide is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.

Cat. No.

A16590

CAS No.

122892-31-3

Itopride hydrochloride

Synonyms: HSR803

Itopride hydrochloride is a potent acetylcholinesterase (AChE) inhibitor and dopamine D2 receptor antagonist. By enhancing gastric motility through its antidopaminergic and anti-AChE effects, Itopride hydrochloride serves as an effective gastrointestinal prokinetic agent. This compound is particularly useful for investigating conditions such as gastroesophageal reflux disease (GERD) and related gastrointestinal disorders.

Cat. No.

A16970

CAS No.

206658-92-6

Tacrine HCl Hydrate

Synonyms: THA hydrochloride hydrate; Tetrahydroaminacrine hydrochloride hydrate

Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.

Cat. No.

A17053

CAS No.

1248-42-6

Pitofenone Hydrochloride

Synonyms: Pitofenone HCl; Baralginketone; Bulgarketone

Pitofenone hydrochloride is an antispasmodic agent. It acts as a potent inhibitor of acetylcholinesterase activity.

Cat. No.

A17291

CAS No.

57-37-4

Benactyzine hydrochloride

Benactyzine hydrochloride is a competitive inhibitor of butyrylcholinesterase (BChE) with a Ki of 0.01 mM, functioning primarily as an anticholinergic agent. It demonstrates significant promise in the study of organophosphate poisoning, aiding research into the mechanisms of cholinergic dysfunction. Its ability to modulate cholinergic activity makes it a valuable tool in neuropharmacological research and therapeutic explorations.

Cat. No.

A17374

CAS No.

1684-40-8

Tacrine HCl

Synonyms: Hydroaminacrine; NSC72108

Tacrine is a derivative of aminoacridine that functions as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively).

Cat. No.

A17514

CAS No.

185106-16-5

Acotiamide

Synonyms: Z-338 free base; YM443 free base

Acotiamide is a selective and reversible inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 1.79 μM. It has demonstrated the ability to enhance gastric contractility and promote accelerated gastric emptying. This compound is valuable for investigating functional dyspepsia related to gastric motility dysfunction and intestinal inflammation.

Cat. No.

A17599

CAS No.

7212-44-4

Nerolidol

Synonyms: BRN 1724135; FCI 119b

Nerolidol is a synthetic AChE inhibitor and F0F1-ATP synthase modulator. It acts as a sedative, inhibits growth of bacteria and fungi, and decreases the mitochondrial transmembrane electric potential to induce cell death in hepatocarcinoma cells.

Cat. No.

A17722

CAS No.

25905-77-5

Minaprine

Synonyms: Cantor; Minaprina; Minaprinum; Brantur; Agr 1240

Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.