mAChR

Cat. No.

A13761

CAS No.

65-31-6

(-)-Nicotine ditartrate

(-)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine recepto).

Cat. No.

A14217

CAS No.

886047-22-9

LY2119620

Synonyms: LY-2219620

LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.

Cat. No.

A10180

CAS No.

590-63-6

Bethanechol chloride

Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors.

Cat. No.

A11372

CAS No.

107233-08-9

Cevimeline (AF-102B)

Synonyms: AF102B

Cevimeline (AF-102B) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.

Cat. No.

A11545

CAS No.

15585-43-0

Metanicotine

Synonyms: Rivanicline; RJR 2403

Metanicotine is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than ??7 receptors(Ki= 36000 nM).

Cat. No.

A12264

CAS No.

560083-42-3

AC260584

AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6.

Cat. No.

A12835

CAS No.

1227923-29-6

MK7622

MK7622 is a muscarinic M1 receptor positive allosteric modulator.

Cat. No.

A13685

CAS No.

141064-23-5

Xanomeline oxalate

Synonyms: LY246708

Xanomeline oxalate is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively).

Cat. No.

A14205

CAS No.

634616-95-8

TBPB

TBPB is an allosteric M1 mAChR agonist with EC50 value of 89 nM that regulates amyloid processing and produces antipsychotic-like activity in rats.

Cat. No.

A14229

CAS No.

150824-47-8

Nitenpyram

Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist.

Cat. No.

A15042

CAS No.

153504-70-2

Cevimeline hydrochloride hemihydrate

Synonyms: Evoxac

Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

Cat. No.

A16669

CAS No.

54-71-7

Pilocarpine Hydrochloride

Synonyms: Pilocarpine HCl; NSC 5746 HCl; (+)-Pilocarpine hydrochloride

Pilocarpine Hydrochloride is a selective agonist for the M3 muscarinic acetylcholine receptor (mAChR). It plays a significant role in stimulating glandular secretion, particularly in the treatment of dry mouth and glaucoma. This compound is valuable in research focused on neuropharmacology, as well as studies investigating cholinergic signaling and its implications in various physiological processes.

Cat. No.

A17156

CAS No.

338747-41-4

BQCA

BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR).

Cat. No.

A17285

CAS No.

62-51-1

Methacholine chloride

Synonyms: Acetyl-beta-methylcholine chloride; Provocholine; Mecholyl chloride; Amechol; Methapharma Brand of Methacholine Chloride; Provokit; Roche Brand of Methacholine Chloride

Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.

Cat. No.

A17385

CAS No.

6109-70-2

Aceclidine hydrochloride

Synonyms: Quinuclidin-3-yl acetate hydrochloride

Aceclidine hydrochloride is a selective modulator of the M3 muscarinic acetylcholine receptor and an agonist of the M1 receptor (EC50: 40 μM). This compound exhibits cycloplegic properties, functioning as a surfactant and tonicity adjustor while optionally enhancing viscosity and providing antioxidant effects. Aceclidine hydrochloride is valuable in research pertaining to ocular disorders, including refractive errors, glaucoma, xerostomia, conjunctivitis, Sjogren's syndrome, lacrimal gland diseases, and esotropia.

Cat. No.

A18092

CAS No.

107220-28-0

Cevimeline hydrochloride

Synonyms: Evoxac; Cevimeline HCl

Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.

Cat. No.

A18488

CAS No.

2180914-37-6

VU6005806

Synonyms: AZN00016130

VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders.

Cat. No.

A18571

CAS No.

147025-53-4

Talsaclidine

Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes.

Cat. No.

A18626

CAS No.

1820812-16-5

TAK-071

TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.

Cat. No.

A19271

CAS No.

120241-31-8

Alvameline

Synonyms: Lu 25-109

Alvameline (Lu25-109) is a partial M1 agonist and M2/M3 antagonist.

Cat. No.

A19842

CAS No.

1451993-15-9

VU0467154

VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.

Cat. No.

A19896

CAS No.

1208222-39-2

VU 0365114

VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM.

Cat. No.

A20406

CAS No.

2092923-21-0

VU 6008667

VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration.

Cat. No.

A20534

CAS No.

56296-18-5

DREADD agonist 21

DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist(EC50=1.7 nM).

Cat. No.

A21095

CAS No.

195615-83-9

Blarcamesine (AVex-73)

Synonyms: AE-37; AVex-73; Anavex-2-73

Blarcamesine, also known as AVex-73 and AE-37, is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. It is an ς receptor ligand.