Protein Kinase C (PKC)

Cat. No.

A46262

CAS No.

99682-33-4

LY 170198

LY 170198 is a potent protein kinase C inhibitor and LTD4 antagonist. This compound exhibits significant biological activity relevant to studies on tumor promotion, oncogene activation, and protein phosphorylation. Additionally, it is valuable for investigating feedback mechanisms in signal transduction pathways and cellular responses to growth factors, making it a useful tool for cancer research and related fields.

Cat. No.

A46263

CAS No.

153207-86-4

Go 7874

Go 7874 is a protein kinase C (PKC) inhibitor that exhibits neuroprotective effects in models of immune-mediated neurotoxicity. This compound mitigates LPS/IFNg-induced neuronal cell death not through conventional PKC inhibition, but by suppressing the expression of inducible nitric oxide synthase (iNOS), leading to decreased nitric oxide (NO) production. Its unique mechanism makes Go 7874 a valuable tool for studying neuroprotective strategies in inflammatory conditions.

Cat. No.

A46264

CAS No.

2692624-38-5

(±)-1,2-Diolein-CC3

Synonyms: 1,2-Dioleoyl-rac-glycerol-CC3

(±)-1,2-Diolein-CC3 is a stable isotope-labeled derivative of (±)-1,2-Diolein, also known as 1,2-Dioleoyl-rac-glycerol-13C3. This compound acts as an activator of protein kinase C (PKC) and is known to enhance calcium ion influx in myotubes. It is particularly useful in research applications studying lipid signaling pathways, cell proliferation, and muscle physiology.

Cat. No.

A50661

CAS No.

119139-23-0

Bisindolylmaleimide IV

Synonyms: Arcyriarubin A

Bisindolylmaleimide IV is a selective inhibitor of protein kinase C (PKC), exhibiting IC50 values between 0.1 and 0.55 μM. It also demonstrates inhibition of protein kinase A (PKA) with IC50 ranging from 3.1 to 11.8 μM. In addition to its kinase inhibitory properties, Bisindolylmaleimide IV effectively inhibits human cytomegalovirus (HCMV) replication in cell culture, displaying an IC50 of 0.2 μM. This reagent is valuable for research applications focused on signal transduction and viral pathogenesis.

Cat. No.

A52270

CAS No.

60562-16-5

1,2-Dimyristoyl-sn-glycerol

1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol that acts as a weak second messenger for the activation of Protein Kinase C (PKC). This compound is utilized in research applications to study PKC signaling pathways, which are crucial in various cellular processes including growth, differentiation, and apoptosis. As a PKC activator, it can help elucidate the role of PKC in different biological contexts and disease models.

Cat. No.

A53084

CAS No.

83519-04-4

Ilmofosine

Synonyms: BM41440

Ilmofosine is a selective inhibitor of protein kinase C, exhibiting potent activity in modulating cellular signaling pathways. This compound induces cell cycle arrest at the G2 phase, highlighting its potential for cancer research. Additionally, Ilmofosine serves as an effective anti-leishmanial agent, making it valuable for studies related to parasitic infections and therapeutic interventions.

Cat. No.

A53665

CAS No.

3102-56-5

DL-erythro-Dihydrosphingosine

DL-erythro-Dihydrosphingosine is a sphingosine-derived protein kinase C (PKC) inhibitor that functions by directly inhibiting phospholipase A2 (PLA2) activity. This compound also attenuates the function of Bcl-2, a protein that plays a crucial role in regulating apoptosis. Additionally, DL-erythro-Dihydrosphingosine inhibits matrix metalloproteinases (MMPs), which are involved in various cellular processes. Its unique biological activity makes it valuable for research in cancer and inflammatory disease models.

Cat. No.

A54176

CAS No.

17817-31-1

Desmethylglycitein

Synonyms: 4',6,7-Trihydroxyisoflavone

Desmethylglycitein (4',6,7-Trihydroxyisoflavone) is an inhibitor of protein kinase C (PKC)α, demonstrating significant anti-cancer and antioxidant activities. It directly binds to CDK1 and CDK2, leading to the suppression of their activity. Additionally, Desmethylglycitein inhibits PI3K in an ATP-competitive manner, affecting downstream signaling pathways and reducing adipogenesis in 3T3-L1 preadipocytes. Its mechanisms make it a valuable tool for research in cancer biology and metabolic disorders.

Cat. No.

A54431

CAS No.

131848-97-0

Bisindolylmaleimide X

Synonyms: BIM-X; Ro31-8425

Bisindolylmaleimide X is a potent protein kinase C (PKC) inhibitor that exhibits cell-penetrating properties. It effectively inhibits the proliferation of CD4 T cells in vitro and shows antagonistic activity against cyclin-dependent kinase 2 (CDK2) with an IC50 of 200 nM. Additionally, Bisindolylmaleimide X suppresses eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. This compound is valuable for studying mechanisms in the immune system and cardiovascular diseases.

Cat. No.

A55098

CAS No.

18417-89-5

Sangivamycin

Synonyms: NSC 65346; BA-90912

Sangivamycin is a nucleoside analog that serves as a potent inhibitor of protein kinase C (PKC) with a Ki value of 10 μM. This compound exhibits significant antiproliferative activity against a diverse range of human cancers, making it a valuable tool for cancer research and therapeutic studies focused on PKC modulation. Its targeted mechanism of action positions Sangivamycin as a promising candidate for further exploration in cancer treatment.

Cat. No.

A57634

CAS No.

2328094-11-5

PKC-iota inhibitor 1

PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι) with an IC50 value of 0.34 μM. This compound demonstrates significant biological activity relevant to cancer research, making it a valuable tool for investigating the role of PKC-ι in tumorigenesis and signal transduction pathways. It is suitable for studies focused on cancer biology and therapeutic interventions targeting PKC-ι.

Cat. No.

A77421

CAS No.

799764-07-1

PKCζ/ι pseudosubstrate inhibitor

PKCζ/ι Pseudosubstrate Inhibitor serves as a specific inhibitor of protein kinase C (PKC) isoforms ζ and ι. This compound exhibits broad-spectrum inhibitory effects on the PKC enzyme family, making it valuable for studies investigating the role of PKC in cell signaling and neurobiology. Additionally, it has been shown to induce memory impairment, which may be relevant for research on cognitive function and associated disorders.