Protein Kinase C (PKC)

Cat. No.

A10864

CAS No.

62996-74-1

Staurosporine

Synonyms: AM-2282; STS

Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.

Cat. No.

A10196

CAS No.

3895-92-9

Chelerythrine Chloride

Chelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner.

Cat. No.

A10356

CAS No.

170364-57-5

Enzastaurin (LY317615)

Synonyms: LY317615

LY317615 (Enzastaurin) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50= ~6 nM).

Cat. No.

A10766

CAS No.

117-39-5

Quercetin (Sophoretin)

Synonyms: Sophoretin; Meletin; Quercetine

Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C.

Cat. No.

A12014

CAS No.

61276-17-3

Verbascoside

Synonyms: Acetoside; Kusaginin

Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 μM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

Cat. No.

A13514

CAS No.

138489-18-6

Ro 31-8220 mesylate

Synonyms: BIM IX; Bisindolylmaleimide IX (mesylate)

Ro 31-8220 mesylate is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.

Cat. No.

A13790

CAS No.

133053-19-7

GO6983

GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.

Cat. No.

A10261

CAS No.

83314-01-6

Bryostatin 1

Synonyms: NSC 339555

Bryostatin 1 is a macrolactone isolated from the marine bryozoan, Bugula neritina, that modulates protein kinase C (PKC) activity. Bryostain 1 induces an initial rapid activation and autophosphorylation of PKC that results in the translocation of the PKC enzyme to the membrane.

Cat. No.

A10286

CAS No.

486-35-1

Daphnetin

Synonyms: 7,8-dihydroxycoumarin

Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25 μM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.

Cat. No.

A11275

CAS No.

112953-11-4

7-Hydroxystaurosporine

Synonyms: UCN-01; KRX-0601

7-Hydroxystaurosporine is a selective protein kinase C (PKC) inhibitor known for its significant antitumor activity. This compound induces apoptosis and inhibits cell proliferation in colon carcinoma and leukemia cells, while also suppressing invasion and migration in glioblastoma cells. Additionally, 7-hydroxystaurosporine demonstrates efficacy in breast cancer xenograft mouse models, making it a valuable tool for research into colon carcinoma, breast cancer, glioblastoma, and leukemia.

Cat. No.

A11554

CAS No.

425637-18-9

Sotrastaurin (AEB071)

Synonyms: AEB 071

Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.

Cat. No.

A12399

CAS No.

169939-94-0

Ruboxistaurin (LY333531)

Synonyms: LY 333531

Ruboxistaurin (LY333531) is a potent, selective inhibitor of Protein Kinase C isozymes, PKC β I(IC50=4.7 nM) and PKC β II (IC50=5.9 nM).

Cat. No.

A12419

CAS No.

136194-77-9

Go 6976

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.

Cat. No.

A12650

CAS No.

120685-11-2

Midostaurin (PKC 412)

Synonyms: CGP 41251; PKC412

PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

Cat. No.

A12829

CAS No.

949100-39-4

Delcasertib

Synonyms: KAI-9803; BMS-875944

Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor.

Cat. No.

A13197

CAS No.

133052-90-1

GF 109203X

Synonyms: GO6850; Bisindolylmaleimide I

GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).

Cat. No.

A14307

CAS No.

278603-08-0

NH125

NH125 is a selective eEF-2 kinase inhibitor.

Cat. No.

A14871

CAS No.

113731-96-7

PKC (19-36)

PKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM).

Cat. No.

A15557

CAS No.

193620-69-8

TAS 301

TAS 301 is an inhibitor of smooth muscle cell migration and proliferation.

Cat. No.

A16212

CAS No.

1046787-18-1

PKC-IN-1

PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1.

Cat. No.

A16213

CAS No.

785718-37-8

NSC305787

NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin.

Cat. No.

A16604

CAS No.

169939-93-9

Ruboxistaurin (LY333531 HCl)

Synonyms: LY-333531

LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.

Cat. No.

A17019

CAS No.

84468-24-6

HA-100 (C1)

Synonyms: HA100

HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50 = 8, 12, and 4 μM, respectively).

Cat. No.

A18627

CAS No.

1564249-38-2

BJE6-106

Synonyms: B-106

BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM).

Cat. No.

A18966

CAS No.

1160501-81-4

PKC-theta inhibitor 1

PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM.