Protein Kinase C (PKC)

Cat. No.

A46185

CAS No.

2230055-52-2

PKCiota-IN-2

PKCiota-IN-2 is a potent inhibitor of Protein Kinase C iota (PKC-ι), exhibiting an IC50 value of 2.8 nM. In addition to its primary target, PKCiota-IN-2 also demonstrates inhibitory activity against PKC-α and PKC-ε with IC50 values of 71 nM and 350 nM, respectively. This compound is valuable for research applications exploring the role of PKC isoforms in signal transduction, cancer, and other diseases.

Cat. No.

A46186

CAS No.

120925-60-2

NA 0345

NA 0345 is a potent protein kinase C (PKC) inhibitor, exhibiting IC50 values of 70 nM in the presence of 12-O-tetradecanoyl-13-acetate and 110 nM in its absence. This compound selectively inhibits PKC activity, effectively reducing the positive inotropic effects associated with α1-adrenergic receptors. NA 0345 is useful in research applications aimed at elucidating the role of PKC in cardiovascular function and signal transduction pathways.

Cat. No.

A46187

CAS No.

152246-44-1

EGFR Peptide

EGFR Peptide is a selective substrate for Protein Kinase C (PKC), facilitating the measurement of PKC activity in various biological contexts. This peptide is instrumental in studies examining PKC's role in cellular signaling pathways, making it a valuable tool for researchers exploring cancer biology, cell proliferation, and differentiation processes. Its specific interaction with PKC allows for accurate assessments of enzyme activity, contributing to a deeper understanding of PKC-mediated signaling mechanisms.

Cat. No.

A46188

CAS No.

309247-49-2

[Glu27]-PKC (19-36)

[Glu27]-PKC (19-36) is a peptide that serves as an inactive control for protein kinase C (PKC) (19-36). As a pseudosubstrate peptide inhibitor, it is designed to maintain PKC in an inactive state without the presence of allosteric activators, such as phospholipids. This reagent is applicable in studies examining the regulation of PKC activity and its role in various cellular signaling pathways. Researchers can utilize [Glu27]-PKC (19-36) to assess the impact of active and inactive states of PKC in experimental setups.

Cat. No.

A46189

CAS No.

388621-67-8

AJH-836

AJH-836 is an activator of Munc13-1 and protein kinase C (PKC) ε/α, exhibiting a Kd of 4.5 nM for PKCα. This compound facilitates the translocation of Munc13-1 from the cytoplasm to the plasma membrane, thereby enhancing synaptic function. AJH-836 is valuable for research related to neurodegenerative diseases, providing insights into synaptic transmission and neuronal communication.

Cat. No.

A46190

CAS No.

508-44-1

Anemonin

Synonyms: Pulsatilla camphor; Anemonine; trans-Anemonin

Anemonin is a dual inhibitor targeting inducible nitric oxide synthase (iNOS) and protein kinase C theta (PKC-θ). This compound significantly reduces the translation and enhances the protein stability of PKC-θ, demonstrating potent anti-inflammatory effects. Anemonin has been shown to alleviate symptoms of dextran sodium sulfate-induced acute ulcerative colitis in murine models, making it a valuable tool for researching inflammation-related diseases.

Cat. No.

A46191

CAS No.

2442-61-7

(±)-1,2-Diolein

Synonyms: 1,2-Dioleoyl-rac-glycerol

(±)-1,2-Diolein is a potent activator of protein kinase C (PKC), a crucial regulator of various cellular processes. This compound enhances calcium influx in myotubes, facilitating studies on muscle physiology and signaling pathways. Its application in research supports investigations into PKC-related mechanisms and their implications in muscle function and disease.

Cat. No.

A46192

CAS No.

309247-50-5

Protein Kinase C β Peptide

Protein Kinase C β Peptide is a peptide fragment derived from Protein Kinase Cβ, which plays a critical role in regulating vascular function. It has been shown that hyperglycemia negatively impacts endothelium-derived nitric oxide production, leading to impaired vasodilation. The inhibition of Protein Kinase Cβ can counteract the reduction in endothelium-dependent vasodilation that occurs during acute hyperglycemia, making this peptide a valuable tool for research into vascular complications associated with diabetes and metabolic disorders.

Cat. No.

A46193

CAS No.

151342-35-7

(S)-Ro 32-0432 free base

(S)-Ro 32-0432 free base is a selective and potent ATP-competitive inhibitor of Protein Kinase C (PKC), with IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε. Additionally, it acts as a selective inhibitor of G protein-coupled receptor kinase 5 (GRK5). (S)-Ro 32-0432 free base effectively inhibits T-cell activation, making it a valuable tool for research into chronic inflammatory and autoimmune diseases.

Cat. No.

A46194

CAS No.

17863-69-3

1,2-Didecanoylglycerol

1,2-Didecanoylglycerol is a synthetic diacylglycerol that functions as a potent activator of protein kinase C (PKC). It is metabolized by platelets to form 1,2-didecanoylphosphatidic acid (PA10), which plays a crucial role in cellular signaling pathways. This reagent is widely used in research applications involving cell proliferation, differentiation, and various signaling cascades associated with PKC activation.

Cat. No.

A46195

CAS No.

1072301-79-1

ɛPKC(85–92),Myristoylated

ɛPKC(85–92), Myristoylated is a cell-permeable peptide that activates Protein Kinase C (PKC) through myristoylation. This compound enhances nitric oxide (NO) release in cultured human umbilical vein endothelial cells (HUVECs), making it a valuable tool for investigating endothelial cell function and signaling pathways. Research applications include studies on vascular biology and the modulation of PKC activity in various physiological and pathological processes.

Cat. No.

A46196

CAS No.

60796-70-5

Gnidimacrin

Gnidimacrin is a protein kinase C (PKC) activator that demonstrates notable anti-proliferative effects on various cancer cell lines. It effectively inhibits growth in human leukemias, stomach cancers, and non-small cell lung cancers in vitro, while also exhibiting antitumor activity against murine leukemias and solid tumors in vivo. This compound can be utilized in research focused on leukemia and solid tumor biology, contributing to the understanding of PKC signaling pathways in cancer therapy.

Cat. No.

A46197

CAS No.

908012-19-1

PKCη pseudosubstrate inhibitor,myristoylated

PKCη pseudosubstrate inhibitor, myristoylated is a cell-permeable compound designed to inhibit protein kinase C eta (PKCη) activity by mimicking its substrate. This inhibitor allows for the exploration of PKCη’s role in various signaling pathways, facilitating studies on its biological functions in cell proliferation, differentiation, and apoptosis. Researchers can utilize this tool to investigate the therapeutic potential of modulating PKCη activity in various diseases.

Cat. No.

A46198

CAS No.

338949-46-5

KRPpSQRHGSKY-NH2

KRPpSQRHGSKY-NH2 is a bioactive peptide that serves as a phosphorylated substrate for protein kinase C (PKC). This compound is utilized in research applications to study signaling pathways and phosphorylation events mediated by PKC. Its role in cellular processes makes it valuable for investigating various biological functions and potential therapeutic targets.

Cat. No.

A46199

CAS No.

72618-10-1

CP-46665 dihydrochloride

Synonyms: CP-46665-1

CP-46665 dihydrochloride is an anticancer agent that primarily targets cellular proliferation. It inhibits the incorporation of tritiated thymidine into leukemia cells and various human solid tumor cells in vitro. This compound leads to the loss of surface characteristics in tumor cells and disrupts cell membranes, thereby effectively inhibiting cell growth and proliferation. It is a valuable tool for research applications focused on cancer biology and therapeutic development.

Cat. No.

A46200

CAS No.

1221964-50-6

PS315

PS315 is an allosteric inhibitor of protein kinase C (PKC) that targets the PIF-pocket of atypical PKC isoforms. By inducing a displacement of the active site residue Lys111, PS315 effectively inhibits both full-length PKCζ (IC50 = 10 µM) and PKCη (IC50 = 30 µM). This compound has demonstrated anti-cancer properties, making it a valuable tool for research into PKC-related signaling pathways and cancer therapeutics.

Cat. No.

A46201

CAS No.

2948289-20-9

PKCTheta-IN-1

PKCTheta-IN-1 is a selective inhibitor of Protein Kinase C Theta (PKCθ), exhibiting an IC50 value of 0.1 nM. This compound disrupts PKCθ-mediated signaling pathways, contributing to its potential in immunological research and cellular proliferation studies. Its specificity makes it a valuable tool for investigating the role of PKCθ in T-cell activation and other related processes.

Cat. No.

A46202

CAS No.

149839-94-1

Protein Kinase C (660-673)

Synonyms: PKC βII (660-673)

Protein Kinase C (660-673) is a peptide derived from the PKC βII isoform, specifically designed to exhibit RACK1-binding affinity. This peptide serves as a valuable tool for studying the interactions of PKC βII with RACK1, providing insights into signaling pathways mediated by Protein Kinase C. Its unique structural properties make it suitable for investigating PKC βII's role in cellular processes, including proliferation and differentiation.

Cat. No.

A46203

CAS No.

611234-91-4

PKC-IN-7

PKC-IN-7 is a selective inhibitor of protein kinase C (PKC). This compound demonstrates significant anti-proliferative effects in various cancer cell lines and is valuable for investigating the role of PKC in cancer signaling pathways. It is suitable for research applications focused on tumor biology, cell signaling, and therapeutic development for PKC-related diseases.

Cat. No.

A46204

CAS No.

26486-92-0

6-Deoxyisojacareubin

6-Deoxyisojacareubin is a specific inhibitor of Protein Kinase C (PKC) that exhibits concentration-dependent inhibition of QGY-7703 cell proliferation. As a natural product derived from Garcinia nervosa, it serves as a valuable tool in cancer research to explore PKC-related signaling pathways and its effects on tumor cell growth. Its unique properties make it suitable for studies aiming to elucidate the role of PKC in various cancer types.

Cat. No.

A46205

CAS No.

99026-78-5

[Ala113]MBP(104-118)

[Ala113]MBP(104-118) is a noncompetitive inhibitor of protein kinase C (PKC), demonstrating IC50 values between 28-62 μM. This peptide is crucial for studying the regulatory mechanisms of PKC in various biological contexts. Its inhibition of PKC activity makes it a valuable tool for investigating signal transduction pathways and their implications in disease states. Researchers can utilize this reagent to explore PKC's role in cellular processes, contributing to the understanding of therapeutic targets in cancer and other diseases.

Cat. No.

A46206

CAS No.

120298-73-9

pTH-Related Protein (1-40) (human, mouse, rat)

pTH-Related Protein (1-40) is an activator of the parathyroid hormone receptor (PTHR) and protein kinase C isoforms α and β. This peptide enhances calcium uptake in rat intestinal cells by stimulating the PTHR1 receptor, leading to the upregulation of critical calcium transport proteins, including TRPV6, CaBP-D9k, NCX1, and PMCA1. Its biological activity makes it a valuable tool for research focused on calcium signaling and endocrine regulation in both human and animal models.

Cat. No.

A46207

CAS No.

120685-17-8

Staurosporine-Boc

Staurosporine-Boc is a potent non-selective inhibitor of protein kinases, derived from the actinobacterium Streptomyces staurosporeus. This compound effectively inhibits a wide range of protein kinases, including protein kinase C (PKC), as well as tyrosine and serine/threonine kinases. Due to its broad activity profile, Staurosporine-Boc is extensively utilized in biological research, particularly in studies examining cell signaling pathways and related mechanisms.

Cat. No.

A46208

CAS No.

149839-93-0

Protein Kinase C (661-671)

Protein Kinase C (661-671) is a peptide fragment derived from the β1 isoform of protein kinase C (PKC). This fragment is crucial for studying the regulatory mechanisms of PKC in cellular growth control and its role in tumor promotion. It serves as an important tool for research into cancer biology and signaling pathways associated with PKC activity.

Cat. No.

A46209

CAS No.

79083-69-5

Sapintoxin A

Sapintoxin A is a phorbol ester derived from the unripe fruits of Sapium indicum. This compound exhibits significant biological activity by acting on protein kinase C (PKC) pathways, making it valuable in the study of signal transduction and cancer research. Its applications include investigating the role of PKC in various cellular processes and understanding tumorigenesis mechanisms.