BMS-708163 (Avagacestat)

Catalog No.: A10157
Gamma-secretase inhibitor
BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
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Product Name Price Stock Qty
BMS-708163 5mg
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BMS-708163 10mg
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BMS-708163 50mg
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BMS-708163 100mg
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BMS-708163 10mM * 1mL in DMSO
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
Target Value
Product Information
Catalog Num A10157
Formula C20H17ClF4N4O4S
Molecular Weight 520.8
CAS Number 1146699-66-2
SMILES C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)[C@H](CCC(F)(F)F)C(=O)N)Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

In vitro DMSO 90 mg/mL (172.78 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.2 mL 96.01 mL 192.01 mL
0.5 mM 3.84 mL 19.2 mL 38.4 mL
1 mM 1.92 mL 9.6 mL 19.2 mL
5 mM 0.38 mL 1.92 mL 3.84 mL
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