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Biological Activity
BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
Targets
| γ secretase(Aβ42) | γ secretase(Aβ40) | |||
| 0.27 nM | 0.3 nM |
| In vitro | DMSO | 90 mg/mL (172.78 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.2 mL | 96.01 mL | 192.01 mL |
| 0.5 mM | 3.84 mL | 19.2 mL | 38.4 mL |
| 1 mM | 1.92 mL | 9.6 mL | 19.2 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.84 mL |
*The above data is based on the productmolecular weight 520.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10157 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1146699-66-2 |
| Formula | C20H17ClF4N4O4S |
| M. Wt | 520.8 |
| Purity | >98% |
| Synonyms | BMS708163 |
| SMILES | C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)[[email protected]](CCC(F)(F)F)C(=O)N)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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