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BMS-708163 (Avagacestat)

Catalog No.: A10157

Gamma-secretase inhibitor

BMS-708163 (Avagacestat)

BMS-708163 (Avagacestat) Chemical Structure

CAS NO. 1146699-66-2

BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.

Availability: In stock

Package Price Qty
5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
γ secretase(Aβ42) γ secretase(Aβ40)
0.27 nM0.3 nM
In vitro DMSO 90 mg/mL (172.78 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.2 mL 96.01 mL 192.01 mL
0.5 mM 3.84 mL 19.2 mL 38.4 mL
1 mM 1.92 mL 9.6 mL 19.2 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 520.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10157
Actions Inhibitor
CAS No. 1146699-66-2
Formula C20H17ClF4N4O4S
M. Wt 520.8
Purity >98%
Synonyms BMS708163
SMILES C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)[[email protected]](CCC(F)(F)F)C(=O)N)Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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