P-gp

Cat. No.

A11080

CAS No.

121584-18-7

Valspodar (PSC-833)

Synonyms: PSC833; Amdray

PSC-833 is a kind of P-glycoprotein (P-gp) modulator that inhibits P-gp-mediated multidrug-resistance (MDR).

Cat. No.

A11584

CAS No.

206873-63-4

Tariquidar (XR9576)

Synonyms: XR 9576??XR9576??D06008; XR9576

Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor.

Cat. No.

A10549

CAS No.

167465-36-3

LY335979 (Zosuquidar 3HCl)

Synonyms: RS-33295-198; Zosuquidar 3HCl

LY335979 (Zosuquidar trihydrochloride) is a potent highly selective P-gp inhibitor.

Cat. No.

A12324

CAS No.

143664-11-3

Elacridar (GF120918)

Synonyms: GF120918

Elacridaris a prototypical BCRP inhibitor which inhibits the Bcrp1-mediated transport.

Cat. No.

A12249

CAS No.

67812-42-4

Norverapamil hydrochloride

Synonyms: (±)-Norverapamil hydrochloride; D591 hydrochloride

Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

Cat. No.

A13033

CAS No.

1609138-51-3

TTT-28

TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity.

Cat. No.

A13384

CAS No.

2050747-49-2

P-gp inhibitor 1

P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance.

Cat. No.

A13531

CAS No.

216227-54-2

ONT-093

Synonyms: OC144-093

ONT-093 is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy.

Cat. No.

A13532

CAS No.

197509-46-9

Laniquidar

Synonyms: R101933

Laniquidar is a third-generation P-gp inhibitor, which has been used in clinic trials for modulating multidrug resistance transporters.

Cat. No.

A13533

CAS No.

174254-13-8

Biricodar dicitrate (VX-710)

Synonyms: VX-710 dicitrate; VX-710

Biricodar dicitrate (VX-710 dicitrate) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.

Cat. No.

A13961

CAS No.

625375-83-9

XR9576

Synonyms: Tariquidar methanesulfonate hydrate

XR9576 is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer

Cat. No.

A15077

CAS No.

143851-98-3

Elacridar hydrochloride

Synonyms: GF 120918A

Elacridar hydrochloride is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.

Cat. No.

A15289

CAS No.

167354-41-8

Zosuquidar

Synonyms: LY335979

Zosuquidar is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.

Cat. No.

A16080

CAS No.

1031367-64-2

MC 70 HCl

MC-70 is a potent P-gp inhibitor (EC50 = 0.69 uM).

Cat. No.

A16195

CAS No.

1253452-78-6

KS-176

KS-176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 uM in Pheo A and Hoechst 33342 assays respectively).

Cat. No.

A16483

CAS No.

119478-55-6

Danofloxacin mesylate

Synonyms: CP 76136-27

Danofloxacin mesylate is a fluoroquinolone antimicrobial agent that exerts its bactericidal activity primarily through the inhibition of bacterial DNA gyrase, a crucial enzyme for DNA replication. This compound displays a broad spectrum of effectiveness against various bacterial strains. Additionally, Danofloxacin mesylate is recognized as a substrate for ATP-dependent efflux transporters, including P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2), making it relevant for studies on drug resistance mechanisms in bacteria. This agent is primarily utilized in veterinary medicine and research on antibiotic efficacy and resistance.

Cat. No.

A17049

CAS No.

858474-14-3

NSC 23925

NSC 23925 is a plasma membrane glycoprotein 1 (Pgp1) inhibitor to reverse multidrug resistance (MDR1).

Cat. No.

A18393

CAS No.

1451741-22-2

FD 12-9

FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity.

Cat. No.

A19905

CAS No.

313397-13-6

Reversan

Synonyms: CBLC4H10

Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor.

Cat. No.

A20054

CAS No.

2249749-39-9

P-gp modulator 1

P-gp modulator 1 is a high affinity, orally available modulator of P-glycoprotein (Pgp), can reverse the Pgp-mediated multidrug resistance ((MDR).

Cat. No.

A21212

CAS No.

849675-66-7

Encequidar

Synonyms: HM30181; HM30181A

Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein.

Cat. No.

A21464

CAS No.

159997-94-1

Biricodar

Synonyms: VX-710

Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.

Cat. No.

A21556

CAS No.

849675-87-2

Encequidar mesylate

Synonyms: HM30181 mesylate; HM 30181; HM30181A mesylate; HM 30181A

Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor.

Cat. No.

A22042

CAS No.

129716-58-1

Dofequidar

Synonyms: MS-209

Dofequidar, also known as MS-209, is a quinolone-derived sphingomyelin synthase inhibitor that blocks P-glycoprotein and multidrug resistance-associated protein-1, is under development by Schering for the potential treatment of multidrug resistant tumors.

Cat. No.

A24153

CAS No.

17290-70-9

Isosinensetin

Isosinensetin is a bioactive flavonoid compound with diverse pharmacological properties. It acts as a dual inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 2.61 µM and a Kᵢ of 0.92 µM for PTP1B, indicating its potential in antiviral and metabolic disease research. Additionally, isosinensetin inhibits P-glycoprotein (P-gp) activity in MDR1-MDCKII cells, suggesting its utility in overcoming multidrug resistance. Isosinensetin exhibits multiple therapeutic effects, including anti-tumor, anti-viral, anti-inflammatory, and antioxidant activities. These properties support its application in the research of various conditions such as cancer, chronic inflammation, osteoporosis, diabetes, and infectious diseases.