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TRP Channel

Transient receptor potential (TRP) channel modulators act on cation channels that sense heat, cold and irritants. The mammalian family has six subfamilies, including vanilloid (TRPV), ankyrin (TRPA), canonical (TRPC) and melastatin (TRPM) channels. TRP channels respond to temperature, touch, osmotic changes and plant-derived compounds, so they are often described as cellular sensors. Cloning of the capsaicin receptor TRPV1 in 1997 identified it as a heat-activated ion channel in pain-sensing neurons. AMG517 and SB-705498 are TRPV1 antagonists, while A 967079 blocks TRPA1 and optovin activates TRPA1 when exposed to light. Pyr10 inhibits TRPC3, and Pico145 inhibits channels formed by TRPC1, TRPC4 and TRPC5. The spider toxin peptide GsMTx4, an inhibitor of mechanosensitive channels, is also listed under Piezo Channel.

Items 26-27 of 27

  • Bisandrographolide A
    Cat. No.
    A68869
    CAS No.
    160498-00-0

    Bisandrographolide A

    Synonyms: BAA

    Bisandrographolide A is a potent TRPV4 channel activator with an EC50 ranging from 790 to 950 nM. This compound has demonstrated anti-inflammatory, immunostimulant, and antihypertensive properties. Additionally, Bisandrographolide A binds to CD81, leading to functional suppression, making it valuable for research applications in inflammation, immune response, and cardiovascular studies.

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    1 mg
    $1,090.00
    5 mg
    $2,040.00
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  • Cyclo(-asp-gly)
    Cat. No.
    A68877
    CAS No.
    52661-97-9

    Cyclo(-asp-gly)

    Cyclo(-asp-gly) is a cyclic dipeptide that functions as a TRPV1 stimulator, enhancing the activity of the transient receptor potential vanilloid 1 ion channel. This compound is utilized in research applications related to pain signaling and sensory perception, making it a valuable tool in studies focused on nociception and the mechanisms of pain modulation. Its role in activating TRPV1 provides insights into potential therapeutic approaches for pain management.

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    All 3 sizes

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