AG-014699 (Rucaparib)

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PARP inhibitor

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Catalog No. A10045

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AG-014699 5mg A10045-5

Regular Price: $60.00

Special Price: $48.00

AG-014699 25mg A10045-25

Regular Price: $220.00

Special Price: $176.00

AG-014699 50mg A10045-50

Regular Price: $350.00

Special Price: $280.00

AG-014699 100mg A10045-100

Regular Price: $580.00

Special Price: $464.00

AG-014699 10mM * 1mL in DMSO A10045-10mM-D

Regular Price: $110.00

Special Price: $88.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.

AG-014699 (Rucaparib)

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Chemical Information

Catalog Num A10045
Actions Inhibitor
M. Wt 421.4
Formula C19H18FN3O.H3PO4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 459868-92-9
Synonyms AG014699, PF-01367338,AG-014447 (as free base)
SMILES code CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O
Chemical Name 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate

Biological Activity

Description
AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
Targets
PARP (Cell-free assay)
1.4 nM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 84 mg/mL (199.35 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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