TNF-α

Cat. No.

A26297

CAS No.

1049741-03-8

SPD304 dihydrochloride

SPD304 dihydrochloride is a selective inhibitor of tumor necrosis factor alpha (TNF-α), functioning by promoting the dissociation of TNF trimers to obstruct the interaction between TNF and its receptor. With an IC50 of 22 μM, SPD304 effectively inhibits in vitro binding of TNF-α to TNF receptor 1 (TNFR1). This compound is primarily utilized in research applications focused on inflammatory diseases and cytokine signaling pathways.

Cat. No.

A31061

CAS No.

2614-06-4

(R)-Thalidomide

Synonyms: (R)-(+)-Thalidomide

(R)-Thalidomide is the R-enantiomer of Thalidomide, primarily identified for its psychomotor stabilizing properties. This enantiomer exhibits a range of biological activities, including anti-inflammatory and immunomodulatory effects. It is utilized in research applications focused on neurological and hematological disorders, providing insights into therapeutic potential and mechanisms of action.

Cat. No.

A35879

CAS No.

1700655-93-1

EGR-1-IN-3

EGR-1-IN-3 is a potent disruptor of early growth response 1 (EGR-1) DNA binding. This compound effectively inhibits TNFα-induced EGR-1 binding to DNA, leading to a reduction in the expression of pro-inflammatory genes such as TSLP, IL-31, IL-6, and CCL2. EGR-1-IN-3 is valuable for research applications focused on inflammatory diseases and mechanisms of transcriptional regulation.

Cat. No.

A53921

CAS No.

351062-08-3

Necrostatin-7

Synonyms: Nec-7

Necrostatin-7 is a potent inhibitor of necroptosis, demonstrating an EC50 of 10.6 μM. It selectively modulates necroptotic signaling pathways without inhibiting recombinant RIP1 kinase. This compound is valuable for research applications focusing on cell death mechanisms, inflammation, and neurodegenerative disorders.