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Aldehyde Dehydrogenase (ALDH)

Aldehyde dehydrogenase (ALDH) inhibitors and activators target enzymes that oxidize aldehydes to carboxylic acids. The human ALDH superfamily uses NAD+ as cofactor and includes cytosolic ALDH1A1 and mitochondrial ALDH2. ALDH2 removes acetaldehyde and lipid peroxidation products such as 4-hydroxynonenal. In 2008 the small-molecule activator Alda-1 increased ALDH2 activity and reduced ischemic damage in rat hearts. High ALDH1 activity was reported in 2007 as a marker of normal and malignant human mammary stem cells. NCT-501, NCT-505 and NCT-506 inhibit ALDH1A1 and are used in cancer stem cell studies. RV01 targets ALDH2, while dyclonine hydrochloride and the herbicide propachlor also inhibit ALDH isoforms.

1 Item

  • Cyclosomatostatin
    Cat. No.
    A63848
    CAS No.
    84211-54-1

    Cyclosomatostatin

    Cyclosomatostatin is a potent somatostatin receptor antagonist that specifically targets somatostatin receptor type 1 (SSTR1). This compound effectively inhibits SSTR1 signaling, leading to reduced cell proliferation, decreased ALDH+ cell population size, and diminished sphere formation in colorectal cancer cells. It serves as a valuable tool for research applications focused on understanding the role of somatostatin signaling in cancer biology.

    In stock View Details
    1 mg
    $145.00
    5 mg
    $445.00
    All 3 sizes

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