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Stearoyl-CoA Desaturase (SCD)

SCD inhibitors block stearoyl-CoA desaturase, the enzyme that makes monounsaturated fatty acids. Stearoyl-coenzyme A desaturase (SCD) inserts a cis double bond at the delta-9 position of palmitoyl-CoA and stearoyl-CoA. Its products, palmitoleate and oleate, are built into triglycerides, phospholipids and cholesteryl esters. In 2002, mice lacking SCD1 were shown to be protected against adiposity, which drew interest to the enzyme in metabolic research. A 2015 X-ray structure of mouse SCD1 showed how this membrane enzyme holds its acyl-CoA substrate. A939572, CAY10566 and XEN723 are SCD1 inhibitors, and MK-8245 was designed to act mainly in the liver. SC-26196 inhibits delta-6 desaturase instead, a related fatty acid desaturase.

2 Items

  • E6446 dihydrochloride
    Cat. No.
    A17149
    CAS No.
    1345675-25-3

    E6446 dihydrochloride

    Synonyms: E 6446

    E6446 dihydrochloride is a robust antagonist for TLR7 and TLR9, with potential applications in studying harmful inflammatory responses. Additionally, it acts as a significant inhibitor of SCD1 with a KD of 4.61 μM. This compound can notably suppress adipogenic differentiation and liver lipogenesis via the SCD1-ATF3 pathway. Studies have indicated that E6446 dihydrochloride can enhance liver pathology in mice on a high-fat diet, making it a potential candidate for researching non-alcoholic fatty liver disease (NAFLD).

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    1 mg
    $80.00
    2 mg
    $140.00
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  • PFM046
    Cat. No.
    A74842
    CAS No.
    3053859-57-4

    PFM046

    PFM046 is a potent antagonist of the liver X receptors (LXRα and LXRβ), demonstrating IC50 values of 2.04 μM and 1.58 μM, respectively. This compound effectively inhibits the expression of stearoyl-CoA desaturase 1 (SCD1) and fatty acid synthase (FASN), while promoting the expression of ATP-binding cassette transporter A1 (ABCA1). PFM046 has shown promising antitumor efficacy in preclinical mouse models, making it a valuable tool for research in cancer therapeutics and lipid metabolism pathways.

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