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Monoamine oxidase (MAO) inhibitors act on mitochondrial enzymes that inactivate monoamine neurotransmitters. The two isoforms, MAO-A and MAO-B, are flavin adenine dinucleotide (FAD)-containing enzymes bound to the outer mitochondrial membrane. In 1968, studies with the inhibitor clorgyline revealed two forms of brain MAO, later named MAO-A and MAO-B. MAO-A preferentially oxidizes serotonin, whereas MAO-B prefers phenylethylamine and benzylamine. The 2002 crystal structure of human MAO-B showed an entrance cavity and a substrate cavity, which together reach the flavin cofactor. Inhibitors here include the MAO-A inhibitor moclobemide and the MAO-B inhibitors selegiline hydrochloride and rasagiline mesylate. Safinamide mesylate, a reversible MAO-B inhibitor, is used in Parkinson's disease research.
Synonyms: Molindone HCl; Molindone Hydrochloride salt; Molindone HCl salt; Moban
Molindone HCl is a D2 dopamine receptor antagonist. It also acts as a MAO inhibitor.
5-HT6R/MAO-B modulator 1 is a selective antagonist of the 5-HT6 receptor with Gs signaling activity and serves as an irreversible inhibitor of monoamine oxidase B (MAO-B). This compound demonstrates glioprotective effects and has the capability to reverse memory deficits induced by scopolamine. Additionally, it features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it a versatile tool for chemical biology applications.
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