We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Fatty Acid Synthase (FASN)

Fatty acid synthase (FASN) inhibitors block the enzyme that assembles palmitate from acetyl and malonyl units. FASN is a large homodimeric protein that carries all catalytic steps of fatty acid synthesis on one polypeptide chain. Many tumor cells express high FASN levels and rely on de novo lipogenesis, so the enzyme is studied in cancer metabolism. C75, a synthetic α-methylene-γ-butyrolactone, was described in 2000 as a FASN inhibitor tested in xenografts. Orlistat, known as a pancreatic lipase inhibitor, was shown in 2004 to inhibit the thioesterase domain of FASN. Denifanstat, TVB-3166 and TVB-3664 are later reversible FASN inhibitors from a related chemical series. The list also includes natural products reported to inhibit FASN, such as dihydrocurcumin and praeruptorin B.

1 Item

  • Xelafaslatide
    Cat. No.
    A64891
    CAS No.
    2040964-58-5

    Xelafaslatide

    Synonyms: ONL-1204

    Xelafaslatide is a Fas receptor antagonist that effectively inhibits Fas receptor signaling, thereby blocking downstream apoptosis and inflammatory pathways. This compound demonstrates significant potential in suppressing neuroinflammation and microglial activation in glaucoma models, offering protection to retinal ganglion cells and preventing axonal degeneration. Xelafaslatide is relevant for research focused on glaucoma and related neurodegenerative conditions.

    In stock View Details
    1 mg
    $40.00
    5 mg
    $90.00
    All 3 sizes

1 Item

Added to your cart

View Cart Checkout

    Loading...