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Lipoxygenase

Lipoxygenase (LOX) inhibitors block enzymes that insert molecular oxygen into arachidonic acid and related fatty acids. 5-Lipoxygenase (5-LOX) starts leukotriene synthesis, while 12-LOX and 15-LOX form hydroxylated lipid mediators linked to inflammation and ferroptosis. In 1990, leukotriene synthesis in intact cells was shown to require 5-lipoxygenase-activating protein (FLAP), a membrane partner of 5-LOX. The category covers both points of attack on the leukotriene pathway. Zileuton inhibits 5-LOX directly, whereas MK 886 suppresses leukotriene biosynthesis by binding FLAP. PD146176 is a 15-LOX inhibitor that also appears in ferroptosis research, where lipid peroxidation drives cell death. Baicalein, a flavone from Scutellaria baicalensis roots, is a plant-derived lipoxygenase inhibitor used across several of these models.

5 Items

  • UCB-35440
    Cat. No.
    A33907
    CAS No.
    299460-62-1

    UCB-35440

    UCB-35440 is an orally active antagonist of the histamine H1 receptor and a selective inhibitor of 5-lipoxygenase. It demonstrates significant inhibition of leukotriene B4 (LTB4) formation in human whole blood, as well as a reduction in polymorphonuclear cell infiltration in mouse models. UCB-35440 also effectively inhibits histamine-induced bronchoconstriction and alleviates skin inflammation in guinea pig studies. This compound is suitable for research applications related to asthma and inflammatory skin conditions.

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    1 mg
    $60.00
    5 mg
    $300.00
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  • Naloxone fluorescein acetate
    Cat. No.
    A45103
    CAS No.
    2080300-52-1

    Naloxone fluorescein acetate

    Naloxone fluorescein acetate is a fluorescent derivative of Naloxone, an opioid antagonist that serves as a critical antidote for reversing opioid overdose effects. This compound enables the visualization of Naloxone's pharmacological activity in biological systems through fluorescent detection. Key applications for this reagent include opioid research, overdose studies, and the development of novel therapeutic strategies in addiction and pain management.

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  • N-Dealkylated-mPEG7-Naloxol
    Cat. No.
    A70379
    CAS No.
    2194602-13-4

    N-Dealkylated-mPEG7-Naloxol

    N-Dealkylated-mPEG7-Naloxol is a metabolite of Naloxegol, functioning primarily as an opioid receptor antagonist. This compound is relevant for research involving opioid receptor modulation and can aid in investigating the pharmacokinetics and pharmacodynamics of Naloxegol. Its unique structural features make it suitable for applications in drug metabolism studies and the exploration of opioid receptor interactions.

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  • Raloxifene 6,4'-Bis-β-D-glucuronide
    Cat. No.
    A70469
    CAS No.
    182507-20-6

    Raloxifene 6,4'-Bis-β-D-glucuronide

    Raloxifene 6,4'-Bis-β-D-glucuronide is a metabolite of Raloxifene, functioning primarily as a selective estrogen receptor antagonist. This compound is significant in research related to osteoporosis prevention and estrogen receptor modulation. It serves as an important tool for studying the pharmacokinetics and biological effects of Raloxifene in various cellular contexts.

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    1 mg
    $955.00
    All 1 sizes
  • ALR-38
    Cat. No.
    A76478
    CAS No.
    241127-61-7

    ALR-38

    ALR-38 is a selective 5-lipoxygenase (5-LOX) antagonist with an IC50 value of 1.1 μM, demonstrating significant anti-inflammatory properties. This compound effectively lowers reactive oxygen species (ROS) levels in neutrophils, making it valuable for research into inflammation and related pathological conditions. ALR-38 serves as a potential tool for studying the role of 5-LOX in inflammatory responses and developing therapeutic strategies.

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