Integrin

Cat. No.

A11614

CAS No.

455264-31-0

Zaurategrast (CDP323)

Synonyms: CDP-323

CDP323 is a small-molecule prodrug antagonist of the vascular cell adhesion molecule 1 binding to ??4-integrins

Cat. No.

A12787

CAS No.

402567-16-2

Firategrast (SB 683699)

Synonyms: SB-683699

Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS).

Cat. No.

A13423

CAS No.

1320346-97-1

GLPG0187

GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM.

Cat. No.

A13783

CAS No.

150915-40-5

Tirofiban Hydrochloride Hydrate

Tirofiban, Hydrochloride Hydrate is a specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist.

Cat. No.

A16751

CAS No.

144494-65-5

Tirofiban

Synonyms: L700462; MK383

Tirofiban is a selective and reversible antagonist of the Gp IIb/IIIa receptor, primarily functioning to inhibit fibrinogen binding. This compound exhibits significant antithrombotic activity, making it valuable in studies focused on platelet aggregation and thrombus formation. Additionally, Tirofiban has been shown to promote endothelial cell proliferation and migration through increased production of vascular endothelial growth factor (VEGF). Its capabilities extend to reducing myocardial no-reflow and ischemia-reperfusion injury by improving microvascular structure and endothelial function in ischemic tissues.

Cat. No.

A17118

CAS No.

232271-19-1

TR-14035

TR-14035 is a dual antagonist of α4β7 and α4β1 integrins.

Cat. No.

A17198

CAS No.

1215333-48-4

GR 144053 trihydrochloride

Synonyms: GR144053

GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist.

Cat. No.

A17199

CAS No.

188627-80-7

Eptifibatide

Eptifibatide is a potent glycoprotein IIb/IIIa antagonist (GPIIb/IIIa; Kd = 120 nM) that inhibits platelet aggregation.

Cat. No.

A17204

CAS No.

893397-44-9

BMS-688521

BMS-688521 is a small molecule antagonist of leukocyte function associated antigen-1 (LFA-1).

Cat. No.

A17299

CAS No.

1025967-78-5

Lifitegrast

Synonyms: SAR-1118; brand name: Xiidra.

Lifitegrast (SAR 1118) is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM.

Cat. No.

A19645

CAS No.

148396-36-5

Fradafiban

Synonyms: BIBU-52

Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.

Cat. No.

A20624

CAS No.

455264-30-9

Zaurategrast ethyl ester

Synonyms: CDP323; UCB1184197

Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders.

Cat. No.

A20709

CAS No.

145643-15-8

SC-52012

SC-52012 is an orally active fibrinogen receptor antagonist, with antiplatelet activities.

Cat. No.

A20895

CAS No.

593274-97-6

Integrin Antagonists 27

Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.

Cat. No.

A21173

CAS No.

227963-15-7

MK-0429

Synonyms: L-000845704

MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM.

Cat. No.

A21307

CAS No.

262438-43-7

ATN-161

ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.

Cat. No.

A21412

CAS No.

904763-27-5

ATN-161 trifluoroacetate salt

Synonyms: ATN-161 TFA salt; ATN161

ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.

Cat. No.

A31041

CAS No.

939769-93-4

K34c

K34c is a potent and selective antagonist of the α5β1 integrin. By inhibiting this integrin, K34c effectively reduces chemotherapy-induced premature senescence and enhances apoptosis. This compound is particularly valuable for research in glioblastoma and provides insights into the modulation of tumor cell dynamics.

Cat. No.

A31385

CAS No.

2986315-25-5

K34c hydrochloride

K34c hydrochloride is a selective antagonist of the α5β1 integrin, which plays a significant role in cell adhesion and migration. This compound effectively mitigates chemotherapy-induced premature senescence and enhances apoptosis in cellular models. K34c hydrochloride is particularly applicable in glioblastoma research, providing insights into tumor cell behavior and therapeutic responses.

Cat. No.

A33826

CAS No.

79547-78-7

Levocabastine hydrochloride

Synonyms: R 50547 hydrochloride

Levocabastine hydrochloride is a selective VLA-4 antagonist that effectively interferes with eosinophil infiltration in allergic conjunctivitis. Its primary mechanism involves blocking the binding of VLA-4, thereby reducing inflammatory responses in allergic conditions. Additionally, Levocabastine is noted for its high affinity for the neurotensin receptor subtype 2 (NTR2), making it a valuable tool in research focused on histamine-related pathways and allergy mechanisms. This compound is useful in the study of inflammatory diseases and the development of targeted therapies for allergy treatment.

Cat. No.

A57396

CAS No.

401905-67-7

Carotegrast methyl

Synonyms: AJM300

Carotegrast methyl is a selective antagonist of the α4 integrin, acting to inhibit its interactions. This compound, along with its active metabolite HCA2969, functions as a dual antagonist of both α4β1 and α4β7 integrins. Carotegrast methyl has demonstrated efficacy in preventing the development of colitis in murine models, making it a valuable tool for research in inflammatory diseases and integrin-related pathways.

Cat. No.

A57397

CAS No.

1119276-80-0

Lifitegrast sodium

Synonyms: SAR 1118 sodium; SHP-606 sodium

Lifitegrast sodium is a potent integrin antagonist that disrupts the interaction between intercellular adhesion molecule 1 (ICAM-1) and lymphocyte function-associated antigen 1 (LFA-1). By blocking this binding, Lifitegrast sodium interrupts the T cell-mediated inflammatory response. It demonstrates significant inhibitory action on Jurkat T cell attachment to ICAM-1, with an IC50 of 2.98 nM. This reagent is primarily utilized in research related to dry eye disease and other inflammatory conditions.

Cat. No.

A57398

CAS No.

1629249-40-6

GSK 3008348 hydrochloride

GSK 3008348 hydrochloride is a small molecule antagonist of the integrin αvβ6, with IC50 values of 1.50 nM for αvβ6 and varying degrees of activity against αvβ1, αvβ3, αvβ5, and αvβ8. This compound effectively inhibits TGF-β activation, which is crucial in the progression of fibrosis. Additionally, GSK 3008348 hydrochloride blocks the interaction of foot-and-mouth disease virus (FMDV) with the αvβ6 receptor, preventing viral entry into host cells. Its applications extend to the study of pulmonary fibrosis and diverse cancer research, making it a valuable tool in therapeutic development.

Cat. No.

A57404

CAS No.

1629249-33-7

GSK 3008348

GSK 3008348 is a potent small molecule antagonist of integrin αvβ6, exhibiting IC50 values of 1.50 nM for αvβ6 and varying affinities for other integrins including αvβ1 (2.83 nM) and αvβ3 (12.53 nM). This compound effectively inhibits TGF-β activation, contributing to the reduction of the fibrotic process. Additionally, GSK 3008348 blocks the entry of foot-and-mouth disease virus (FMDV) by preventing its binding to the αvβ6 integrin receptor on host cells. It serves as a valuable tool for research into pulmonary fibrosis and cancer biology.

Cat. No.

A57408

CAS No.

67-30-1

Tetrac

Synonyms: Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid

Tetrac (Tetraiodothyroacetic acid) acts as an integrin antagonist by selectively inhibiting the interaction of thyroid hormones, L-thyroxine (T4) and 3,5,3'-triiodo-L-thyronine (T3), with integrin αvβ3 receptors. This blockade disrupts downstream signaling pathways, leading to significant anti-angiogenic and anti-tumor effects. Tetrac is valuable for research in cancer biology and therapeutic approaches targeting tumor vascularization.