DNA/RNA Synthesis

Cat. No.

A10575

CAS No.

85622-93-1

Methazolastone

Synonyms: Temozolomide; Temodar; Temodal

Methazolastone is a DNA damage inducer.

Cat. No.

A31769

CAS No.

287402-09-9

Dicycloplatin

Dicycloplatin is a DNA damage inducer that primarily activates key regulatory proteins, including biphosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1), and triphosphorylated p53. Its mechanism of action facilitates cell cycle arrest, inhibits proliferation, and promotes apoptosis in various cancer cell lines, specifically prostate cancer PC3 cells and lung cancer NCI/H446 cells. Dicycloplatin is applicable in cancer research, providing insights into therapeutic approaches targeting DNA damage response pathways.

Cat. No.

A32443

CAS No.

2338764-89-7

p53 Activator 2

p53 Activator 2 is a potent DNA double-strand break inducer that intercalates into DNA, leading to significant damage. This compound enhances the expression of key cell cycle regulators, including p53, p-p53, CDK4, and p21, resulting in G2/M phase cell cycle arrest and the induction of apoptosis. Additionally, it down-regulates anti-apoptotic proteins such as Bcl-2 and Bcl-xL, while reducing cyclin B1 levels. p53 Activator 2 exhibits strong anti-proliferative effects against MGC-803 cells, with an IC50 of 1.73 µM, and demonstrates notable anticancer efficacy in MGC-803 xenograft tumor models.

Cat. No.

A37315

CAS No.

6419-19-8

NTPO

Synonyms: Nitrilotris(methylenephosphonic acid)

NTPO (Nitrilotris methylenephosphonic acid) is a potent DNA damage inducer that effectively induces genomic DNA damage and fragmentation, leading to the activation of ATR-mediated cell cycle checkpoints. Its DNA damaging effects can be mitigated by base excision repair (BER) mechanisms, while remaining unaffected by nucleotide excision repair (NER). This compound is useful for research applications focusing on DNA repair pathways, cellular responses to damage, and the study of cell cycle regulation.

Cat. No.

A37355

CAS No.

114580-45-9

FK 973

FK 973 is a dihydrobenzoxazine compound that acts as a DNA crosslinking inducer. It selectively inhibits DNA synthesis and facilitates the formation of DNA cross-links via cytoplasmic activation. Demonstrating significant antitumor efficacy in multiple animal tumor models and human tumor xenografts, FK 973 exhibits relatively low myelosuppressive effects, particularly affecting neural tumor cells. This reagent is valuable for research focused on DNA-targeted antitumor strategies.

Cat. No.

A37918

CAS No.

403-29-2

2-Bromo-4'-fluoroacetophenone

Synonyms: p-Fluorophenacyl bromide

2-Bromo-4'-fluoroacetophenone is a photoinducible DNA cleavage inducer that generates fluorine-substituted phenyl radicals upon excitation and irradiation. This compound effectively cleaves DNA, transforming circular supercoiled DNA into circular relaxed and linear forms in a concentration-dependent manner. It serves as a valuable tool for research applications in cancer biology, facilitating studies on DNA damage and repair mechanisms.

Cat. No.

A37975

CAS No.

301298-87-3

ZIM

ZIM is a norbornene derivative of 4-Aminoantipyrine that functions as a potent inducer of DNA damage. It elicits significant genomic and chromosomal damage, leading to cell death and the activation of phagocytosis. Due to its biological properties, ZIM holds potential for applications in cancer research and chemotherapeutic development.

Cat. No.

A38250

CAS No.

86293-40-5

10-Methoxy-canthin-6-one

Synonyms: Mtx-C

10-Methoxy-canthin-6-one is an alkaloid derivative that serves as a DNA damage inducer by intercalating into DNA. It exhibits significant biological activity by inhibiting cancer cell proliferation, causing G2/M phase arrest, and promoting myeloid differentiation. Additionally, 10-methoxy-canthin-6-one upregulates the expression of myeloperoxidase, CD15, CD11b, and CD14 while activating the p38 MAPK pathway. Its anti-bacterial properties further expand its research applications, particularly in studies related to cancer and infections, including acute myeloid leukemias (AML).

Cat. No.

A38732

CAS No.

5336-53-8

N-Nitrosodibenzylamine

N-Nitrosodibenzylamine serves as a potent DNA damage inducer, primarily functioning through the induction of DNA single-strand breaks (SSBs). This compound is valuable for research exploring genotoxicity and the mechanisms of DNA repair. Its ability to induce cellular stress responses makes it a critical tool for studying DNA damage pathways and their implications in cancer research.