Nucleoside Antimetabolite/Analog

Cat. No.

A55613

CAS No.

15465-92-6

2-Chloro-6-methoxypurine riboside

Synonyms: 2-Chloro-6-O-methyl-inosine

2-Chloro-6-methoxypurine riboside is a hypoxanthine analog known for its mechanism as a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. This compound exhibits cytoprotective properties by inhibiting PARP activity, thereby preventing peroxynitrite-induced mitochondrial depolarization and the subsequent production of superoxides. Its anti-inflammatory effects and role as an indicator of hypoxia make it valuable for research applications in cellular metabolism and oxidative stress studies.

Cat. No.

A55614

CAS No.

90183-59-8

Demethylphosphinothricin

Synonyms: Deamino-alpha-keto-demethylphosphinothricin

Demethylphosphinothricin is a nucleoside metabolite that functions as a potent inhibitor of glutamine synthetase. Its primary mechanism involves the inhibition of amino acid metabolism, leading to disruption of nitrogen assimilation in plants and some microorganisms. This compound is valuable in agricultural research for studying herbicide resistance and in biochemistry for exploring metabolic pathways related to amino acid biosynthesis.

Cat. No.

A55630

CAS No.

18492-10-9

1-(β-D-Xylofuranosyl)-5-methylcytosine

1-(β-D-Xylofuranosyl)-5-methylcytosine is a cytidine analog that functions primarily as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable tool in epigenetics research. It is suitable for studies investigating the role of DNA methylation in gene regulation and cancer biology.

Cat. No.

A55681

CAS No.

256223-98-0

N4-Benzoyl-5’-O-DMT-3’-O-(2-methoxyethyl)-5-methylcytidine

N4-Benzoyl-5’-O-DMT-3’-O-(2-methoxyethyl)-5-methylcytidine is a cytidine analog that functions as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor properties, making it valuable in cancer research. Its unique chemical structure enables investigations into epigenetic modifications and therapeutic approaches targeting DNA methylation pathways.

Cat. No.

A55682

CAS No.

148821-01-6

MANT-GppNHp

MANT-GppNHp is a competitive inhibitor of adenylate cyclase (AC) that serves as a fluorescently labeled GTP analogue. It specifically interacts with the hydrophobic pocket adjacent to the AC catalytic site through its MANT group, effectively obstructing the binding of ATP. This compound is valuable for investigating diseases characterized by elevated AC activity, such as cholera, and offers insights into cellular signaling pathways.

Cat. No.

A55684

CAS No.

78636-53-0

2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine

2'-Deoxy-2'-fluoro-5-methyl-arabinocytidine is a cytidine nucleoside analog that functions primarily as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it valuable in cancer research. It is useful for studying epigenetic regulation and therapeutic strategies targeting methylation-driven processes in various malignancies.

Cat. No.

A55693

CAS No.

1846584-62-0

5-Vinylcytidine

5-Vinylcytidine is a cytidine analog that functions primarily as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it valuable in cancer research and therapeutic investigations. Its ability to alter epigenetic modifications positions it as a useful tool for studying gene regulation and methylation patterns in various biological contexts.

Cat. No.

A55731

CAS No.

565450-78-4

2′-C-Methyl-6-O-methylinosine

2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog that functions primarily by targeting metabolic pathways involving purines. This compound exhibits notable anti-inflammatory properties and has potential applications as an endogenous poly(ADP-ribose) polymerase (PARP) inhibitor, contributing to cytoprotection through the inhibition of PARP activity. Additionally, 2′-C-Methyl-6-O-methylinosine may serve as a valuable indicator of hypoxic conditions in various biological studies, facilitating research into cellular metabolism and stress responses.

Cat. No.

A55737

CAS No.

1613530-22-5

N1-Benzyl pseudouridine

N1-Benzyl pseudouridine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. The compound operates primarily through the inhibition of DNA synthesis and the induction of apoptosis. Its biological activity makes it a valuable tool for research in cancer biology and the development of therapeutic strategies targeting nucleotide metabolism and tumor proliferation.

Cat. No.

A55767

CAS No.

2095417-72-2

6-Methylpurine-2’-deoxy-2’-fluoro-beta-D-arabinoriboside

6-Methylpurine-2’-deoxy-2’-fluoro-beta-D-arabinoriboside is a purine nucleoside analog that exerts its effects primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies, and induces apoptosis in cancer cells. Its properties make it a valuable tool for research into cancer mechanisms and therapeutic interventions.

Cat. No.

A55803

CAS No.

75191-50-3

5’-Deoxy-5’-N-methylaminothymidine

5’-Deoxy-5’-N-methylaminothymidine is a purine nucleoside analog that exhibits significant antitumor activity. It targets indolent lymphoid malignancies primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound is highly valuable for research applications focused on cancer biology and therapeutic development.

Cat. No.

A55804

CAS No.

80681-58-9

2’,3’,5’-Tri-O-acetyl-6-S-methyl-6-thio-guanosine

2’,3’,5’-Tri-O-acetyl-6-S-methyl-6-thio-guanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool for research into cancer therapeutics and the mechanistic understanding of purine metabolism in malignant cells.

Cat. No.

A55816

CAS No.

875302-27-5

(1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol

(1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol is a purine nucleoside analog known for its broad antitumor activity against indolent lymphoid malignancies. This compound exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable tool in cancer research, particularly in studies focused on lymphoid cancer therapies and the modulation of cellular proliferation pathways.

Cat. No.

A55833

CAS No.

209799-75-7

Immucillin-G

Immucillin-G is a potent inhibitor of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism. By inhibiting PNP, Immucillin-G effectively reduces urate levels, making it valuable for research into metabolic disorders, particularly hyperuricemia. Its role in modulating purine metabolism provides significant insights for studies related to gout and metabolic diseases.

Cat. No.

A55844

CAS No.

16719-46-3

7-Deazaadenosine 5'-phosphate

Synonyms: Tubercidin 5'-phosphate; 7-Deaza-AMP

7-Deazaadenosine 5'-phosphate (7-Deaza-AMP) is a nucleotide derivative that serves as a potential substrate or competitive inhibitor for enzymes interacting with 5'-adenylic acid monophosphate. By modulating intracellular signaling pathways, particularly those involving AMP, 7-Deazaadenosine 5'-phosphate can influence various cellular functions. This compound is useful in research applications exploring nucleotide metabolism and signaling events in cellular biology.

Cat. No.

A55845

CAS No.

146196-08-9

2-Chloro-N6-methyl-2’-deoxyadenosine

2-Chloro-N6-methyl-2’-deoxyadenosine is a purine nucleoside analog that demonstrates significant antitumor activity against indolent lymphoid malignancies. This compound exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. It serves as a valuable tool in cancer research, particularly in the study of mechanisms underlying cellular proliferation and programmed cell death.

Cat. No.

A55848

CAS No.

29474-73-5

3-O-Benzoyl-1,2: 5,6-bis(di-O-isopropylidene)-alpha-D-galactofuranose

3-O-Benzoyl-1,2:5,6-bis(di-O-isopropylidene)-alpha-D-galactofuranose is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological efficacy is primarily mediated through the inhibition of DNA synthesis and the induction of apoptosis. This reagent is valuable for research into cancer therapeutics and the mechanisms of nucleoside analog effects in oncological studies.

Cat. No.

A55858

CAS No.

103137-88-8

Ap5dT

Ap5dT is an inhibitor of cytosolic thymidine kinase and mitochondrial enzymes, exhibiting inhibition constants (Kis) of 0.12 μM and 0.50 μM, respectively. This compound is relevant for research on acute myelocytic leukemia, facilitating investigations into thymidine metabolism and its implications in cancer biology. Its selective inhibition properties make Ap5dT a valuable tool for studying metabolic pathways involved in cellular proliferation.

Cat. No.

A55882

CAS No.

176858-79-0

5-Formyl-2’-O-methylcytidine

5-Formyl-2’-O-methylcytidine is a cytidine nucleoside analog that acts as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activity, making it a valuable tool in cancer research and epigenetic studies. Its unique structure allows for the investigation of nucleoside metabolism and modifications within nucleic acid processes.

Cat. No.

A55884

CAS No.

32452-17-8

Guanosine 3',5'-bisdiphosphate

Synonyms: ppGpp

Guanosine 3',5'-bisdiphosphate (ppGpp) acts as a specific inhibitor of guanylate kinases, affecting GTP biosynthesis in chloroplasts. By inhibiting plastid and mitochondrial guanylate kinase activity, ppGpp is crucial for understanding metabolic regulation and signaling processes in plant systems. This reagent is valuable for research applications involving nucleotide metabolism and signaling pathways.

Cat. No.

A55885

CAS No.

2305415-84-1

3’-O-(2-Methoxyethyl)cytidine

3’-O-(2-Methoxyethyl)cytidine is a cytidine analog that functions primarily as an inhibitor of DNA methyltransferases. This compound exhibits significant potential in anti-metabolic and anti-tumor research applications, providing a valuable tool for studying epigenetic regulation and cancer biology. Its ability to interfere with DNA methylation processes makes it an important reagent for investigating cellular pathways associated with gene regulation and tumor progression.

Cat. No.

A55887

CAS No.

68115-81-1

2’-Amino-2’-deoxy-β-D-arabinouridine

2’-Amino-2’-deoxy-β-D-arabinouridine is a purine nucleoside analog known for its antitumor activity against indolent lymphoid malignancies. This compound exerts its biological effects primarily through the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. It is particularly relevant in studies aimed at understanding and developing treatments for specific types of hematological cancers.

Cat. No.

A55954

CAS No.

2305415-79-4

2-Aminomethyl adenosine

2-Aminomethyl adenosine is a purine nucleoside analog known for its antitumor activity against indolent lymphoid malignancies. This compound exerts its effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. Its applications in cancer research make it a valuable tool for studying the mechanisms of tumor cell proliferation and survival.

Cat. No.

A55967

CAS No.

64145-26-2

5'-dAMPS

Synonyms: 2'-Deoxyadenosine 5'-O-thiophosphate

5'-dAMPS is an analogue of 5'-deoxyadenosine monophosphate (5'-dAMP) that serves as a potential substrate, competitive inhibitor, or regulator of enzymes that interact with dAMP. This compound is valuable in biochemical research for studying nucleotide metabolism and enzyme kinetics, particularly in the context of adenine nucleotide chemistry. Its ability to modulate enzyme activity makes it a useful tool for exploring the roles of dAMP-related pathways in cellular processes.

Cat. No.

A55975

CAS No.

60107-04-2

N-(1-Oxopropyl)cytidine

N-(1-Oxopropyl)cytidine is a cytidine analog that serves as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research. Its ability to alter epigenetic regulation provides insights into gene expression modulation and therapeutic strategies in oncology.