Nucleoside Antimetabolite/Analog

Cat. No.

A56189

CAS No.

140712-83-0

Rev dC(Bz)-5'-amidite

Rev dC(Bz)-5'-amidite is a purine nucleoside analog that exerts its effects primarily through the inhibition of DNA synthesis. It demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies, and can induce apoptosis in cancer cells. This compound is valuable for research applications focusing on cancer therapeutics and the study of nucleoside metabolism.

Cat. No.

A56208

CAS No.

104809-18-9

7-Methyl-guanosine-5'-triphosphate disodium

Synonyms: m7GTP disodium

7-Methyl-guanosine-5'-triphosphate disodium is a modified guanosine 5'-phosphate that plays a critical role in cellular signaling and protein synthesis. As a potent cap-dependent translation inhibitor, it effectively disrupts the translation process by targeting the mRNA cap structure. This reagent is valuable for research applications exploring gene expression, translational regulation, and the mechanisms of RNA processing.

Cat. No.

A56215

CAS No.

887113-66-8

N1-Methyl-5-methyl ara-uridine

N1-Methyl-5-methyl ara-uridine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. This compound exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. Its application in research includes studying potential therapeutic strategies for lymphoid cancers and examining the underlying mechanisms of nucleoside analog efficacy in tumor cell lines.

Cat. No.

A56216

CAS No.

2095417-32-4

5-Furan-2-yl-2’-O-methyl uridine

5-Furan-2-yl-2'-O-methyl uridine functions as a purine nucleoside analog with significant biological activity against indolent lymphoid malignancies. This compound exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. Its potential applications in research include the investigation of cancer therapeutics and the study of nucleoside metabolism in various biological systems.

Cat. No.

A56224

CAS No.

205171-04-6

6-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-beta-D-ribofuranosyl)-9H-purine

6-Chloro-9-(2,3,5-tri-O-benzoyl-2-C-methyl-beta-D-ribofuranosyl)-9H-purine is a purine nucleoside analog known for its potent antitumor properties. This compound targets indolent lymphoid malignancies, exerting its effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable tool in cancer research, aiding in the study of therapeutic strategies against various malignancies.

Cat. No.

A56225

CAS No.

5746-29-2

6-O-Methylinosine

6-O-Methylinosine is a hypoxanthine analogue that serves as a key metabolite in purine metabolism. It exhibits significant anti-inflammatory properties and has potential as an endogenous inhibitor of poly(ADP-ribose) polymerase (PARP), contributing to cytoprotection by preventing PARP activity. This compound also offers insights into cellular responses to hypoxia, making it valuable for research in cellular signaling and oxidative stress.

Cat. No.

A56227

CAS No.

152540-75-5

4’-Methyl-5-methyluridine

4’-Methyl-5-methyluridine is a purine nucleoside analog known for its antitumor properties. This compound exhibits significant activity against indolent lymphoid malignancies, primarily through the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable tool in cancer research, contributing to studies focused on therapeutic strategies for lymphoid tumors.

Cat. No.

A56243

CAS No.

2304678-24-6

N4-Benzoyl-7’-O-(4,4’-dimethoxytrityloxy)morpholinocytosine

N4-Benzoyl-7’-O-(4,4’-dimethoxytrityloxy)morpholinocytosine is a cytidine analog that functions primarily as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it valuable for research applications in the study of epigenetic regulation and cancer biology. Its unique structural modifications enhance its stability and bioavailability, facilitating the investigation of cellular processes and therapeutic interventions.

Cat. No.

A56260

CAS No.

70421-30-6

1-β-D-Ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

1-β-D-Ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine is a purine nucleoside analog that exhibits significant antitumor properties. It primarily exerts its biological activity through the inhibition of DNA synthesis and the induction of apoptosis, making it valuable in the study of indolent lymphoid malignancies. This compound is useful for research applications focused on cancer therapeutics and the mechanisms of cancer cell proliferation.

Cat. No.

A56276

CAS No.

161923-50-8

6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine

6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine is a purine nucleoside analog that primarily targets nucleic acid synthesis. Its biological activity includes broad antitumor properties, particularly effective against indolent lymphoid malignancies. Mechanistically, it functions through the inhibition of DNA synthesis and the induction of apoptotic pathways, making it a valuable tool for cancer research and therapeutic development.

Cat. No.

A56290

CAS No.

132138-76-2

BCX-5

Synonyms: PD 141955

BCX-5 is a selective inhibitor of purine nucleoside phosphorylase (PNP), offering an inhibitory potency with a Ki value of 0.08 μM. This compound is known to impede cell proliferation and modulate mixed lymphocyte reactions by elevating levels of inosine and guanosine in plasma. BCX-5 is valuable for research applications in immunology, providing insights into purine metabolism and lymphocyte function.

Cat. No.

A56297

CAS No.

62488-57-7

Dihydro-5-azacytidine

Synonyms: DHAC; NSC 264880

Dihydro-5-azacytidine is a DNA methylation inhibitor that is incorporated into the DNA structure, disrupting normal methylation processes. This compound exhibits antitumor activity, making it a valuable tool for cancer research. Its properties are relevant for studies focused on epigenetic regulation and the development of therapeutic strategies targeting DNA methylation.

Cat. No.

A56310

CAS No.

2305415-99-8

5’-Deoxy-5’-N-(2-chloroethyl)amino thymidine

5'-Deoxy-5'-N-(2-chloroethyl)amino thymidine is a purine nucleoside analog that exerts its biological effects through inhibition of DNA synthesis and induction of apoptosis. This compound demonstrates broad antitumor activity, particularly against indolent lymphoid malignancies. Research applications include investigating the molecular mechanisms of cancer cell proliferation and exploring novel therapeutic strategies in oncology.

Cat. No.

A56353

CAS No.

791585-24-5

5-Fluoro-4’-C-methylcytidine

5-Fluoro-4’-C-methylcytidine is a cytidine nucleoside analog that functions as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research. Its ability to interfere with DNA methylation processes facilitates studies on epigenetic regulation and therapeutic strategies targeting methylation pathways.

Cat. No.

A56356

CAS No.

19341-57-2

5'-AMPS

5'-AMPS is an analogue of 5'-AMP that functions as a substrate and competitive inhibitor of enzymes that interact with 5'-AMP. This compound is utilized in research to explore the regulatory mechanisms of cellular signaling pathways involving AMP, as well as to study enzyme kinetics. Its unique properties make it a valuable tool for dissecting the roles of AMP-related metabolic processes in various biological systems.

Cat. No.

A56378

CAS No.

1446748-33-9

4′,5′-Didehydro-5′-deoxy-5-methyluridine

4′,5′-Didehydro-5′-deoxy-5-methyluridine is a purine nucleoside analog with significant antitumor properties. This compound exhibits its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in the study of indolent lymphoid malignancies. Its use in research can facilitate the understanding of nucleoside metabolism and the development of therapeutic strategies in cancer treatment.

Cat. No.

A56386

CAS No.

80791-88-4

2-Amino-3’-O-methyladenosine

2-Amino-3’-O-methyladenosine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. This compound exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable tool in cancer research, facilitating the investigation of therapeutic strategies targeting nucleoside metabolism and cellular proliferation pathways.

Cat. No.

A56389

CAS No.

93060-34-5

1,2,4-Triazine-3,5-dione 2-β-D-xylopyranoside

1,2,4-Triazine-3,5-dione 2-β-D-xylopyranoside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological activity is primarily mediated through the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable tool in cancer research, providing insights into therapeutic strategies targeting nucleoside metabolism and tumor cell proliferation.

Cat. No.

A56403

CAS No.

2072145-45-8

2’-β-C-Methyl-5-methoxyuridine

2'-β-C-Methyl-5-methoxyuridine is a purine nucleoside analog with significant antitumor activity. It primarily targets indolent lymphoid malignancies, exerting its effects through the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and therapeutic development.

Cat. No.

A56404

CAS No.

30100-83-5

5,6-Dihydro-ara-uridine

5,6-Dihydro-ara-uridine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. This compound primarily exerts its anticancer effects through the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable research tool in the study of cancer therapeutics and cellular mechanisms related to purine metabolism.

Cat. No.

A56436

CAS No.

2077178-99-3

CMX-521

CMX-521 is a nucleoside analog that functions as a potent inhibitor of the RNA-dependent RNA polymerase (RdRp) of norovirus. This compound effectively suppresses both murine norovirus (MNV) and human norovirus, making it a valuable tool for research into norovirus infections. Its inhibitory properties are essential for studies focused on antiviral development and mechanisms of norovirus replication.

Cat. No.

A56438

CAS No.

4914-73-2

2-Amino-6-meThythio-9-(β-D-ribofuranosyl)-9H-purine

2-Amino-6-methylthio-9-(β-D-ribofuranosyl)-9H-purine is a purine nucleoside analog that exerts its biological activity primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor activity against indolent lymphoid malignancies, making it a valuable tool for cancer research. Its mechanisms may involve the induction of apoptosis, providing insight into therapeutic strategies targeting neoplastic diseases.

Cat. No.

A56439

CAS No.

2422149-84-4

Antiangiogenic agent 2

Antiangiogenic agent 2 is a potent inhibitor of thymidine phosphorylase, exhibiting an IC50 of 39.71 μM. This compound demonstrates significant anti-angiogenic activity, making it a valuable tool for research focused on cancer biology and therapeutics targeting tumor vasculature. It can be utilized in studies aimed at understanding angiogenesis and developing novel anti-cancer strategies.

Cat. No.

A56462

CAS No.

91713-46-1

3,5-O-Ditoluoyl 6-chloropurine-9-β-D-deoxyriboside

3,5-O-Ditoluoyl 6-chloropurine-9-β-D-deoxyriboside is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. This compound exerts its effects primarily through the inhibition of DNA synthesis and the induction of apoptotic pathways. It serves as a valuable tool in cancer research, aiding in the study of therapeutic strategies targeting purine metabolic pathways.

Cat. No.

A56542

CAS No.

15761-83-8

5-Phenyluracil

5-Phenyluracil is a potent inhibitor of thymidine phosphorylase, an enzyme involved in nucleoside metabolism. This compound exhibits significant anti-tumor activity by disrupting the salvage pathway of nucleotides, making it relevant for cancer research. Its selective inhibition of thymidine phosphorylase highlights its potential utility in exploring cancer therapeutics and related biological pathways.