Nucleoside Antimetabolite/Analog

Cat. No.

A55274

CAS No.

1803075-42-4

Brivoligide

Synonyms: AYX1

Brivoligide (AYX1) is a double-stranded, unprotected oligonucleotide composed of 23 base pairs, functioning as a pain inhibitor. It has demonstrated efficacy in reducing acute post-surgical pain through its ability to mimic the DNA sequence typically bound by the transcription factor EGR1 on chromosomes. This unique mechanism makes Brivoligide a valuable tool for research applications focused on pain management and therapeutic interventions in pain-related conditions.

Cat. No.

A55298

CAS No.

119644-22-3

Raluridine

Synonyms: 935U83

Raluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are primarily mediated through the inhibition of DNA synthesis, leading to cell cycle arrest and the induction of apoptosis. This agent serves as a valuable tool in cancer research, facilitating studies aimed at understanding tumor biology and developing novel therapeutic strategies.

Cat. No.

A55308

CAS No.

163586-86-5

N-Isobutyryl-2', 3'-acetyl-guanosine

N-Isobutyryl-2',3'-Acetyl-Guanosine is a guanosine nucleoside derivative that serves as a substrate or inhibitor for various enzymatic reactions involving RNA metabolism. This compound is significant in studies investigating nucleoside signaling pathways and the modulation of guanosine-related biological processes. Its use can facilitate research into therapeutic strategies for diseases related to nucleoside metabolism.

Cat. No.

A55358

CAS No.

30685-57-5

Homouridine

Homouridine is an uridine analogue that acts as an MMP-2 inhibitor, exhibiting an IC50 of 150 μM for compound I. This compound demonstrates significant biological activity through its ability to inhibit TNF-α binding to the TNF-αR1, making it valuable for research applications focused on inflammatory responses and extracellular matrix remodeling. Homouridine serves as a vital intermediate in the synthesis of MMP-2 inhibitors, facilitating studies in cancer and tissue repair mechanisms.

Cat. No.

A55360

CAS No.

59892-37-4

5-Nitro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone

5-Nitro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone is a purine nucleoside analog that exerts its biological effects primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the induction of apoptosis and disruption of nucleic acid metabolism, making it a valuable reagent for cancer research and drug development.

Cat. No.

A55386

CAS No.

2072145-25-4

2’-Deoxy-2’-fluoro-N3-(2S)-(2-amino-3-carbonyl] propyl-beta-D-arabinouridine

2’-Deoxy-2’-fluoro-N3-(2S)-(2-amino-3-carbonyl] propyl-beta-D-arabinouridine is a purine nucleoside analog that exerts its biological activity through the inhibition of DNA synthesis. This compound demonstrates significant antitumor effects, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting nucleic acid metabolism. Its applications in cancer research make it a valuable tool for investigating therapeutic strategies and understanding the mechanistic pathways involved in tumorigenesis.

Cat. No.

A55387

CAS No.

2305416-01-5

5’(R)-C-Methyl-2-thiouridine

5’(R)-C-Methyl-2-thiouridine is a purine nucleoside analogue that exerts its biological effects primarily through the inhibition of DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development.

Cat. No.

A55396

CAS No.

1296177-16-6

DFP-11207

DFP-11207 is an orally active fluoropyrimidine cytotoxic agent designed to target and enhance the pharmacological activity of 5-fluorouracil (5-FU). It functions as a pro-drug that incorporates a reversible dihydropyrimidine dehydrogenase (DPD) inhibitor and a potent orotate phosphoribosyltransferase (OPRT) inhibitor, which together mitigate gastrointestinal and myelosuppressive toxicities associated with traditional 5-FU therapy. DFP-11207 is primarily utilized in cancer research, providing insights into more effective and safer chemotherapeutic strategies.

Cat. No.

A55398

CAS No.

2305415-94-3

2’,3’-Bis(O-(t-butyldimethylsilyl)-5-methoxyuridine

2',3'-Bis(O-(t-butyldimethylsilyl)-5-methoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily through the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. Its unique structure enhances cellular uptake and stability, facilitating studies in nucleoside metabolism and targeted cancer therapies.

Cat. No.

A55408

CAS No.

135123-34-1

2’-Deoxy-2’-fluoro-5-methyl-4’-thio-β-D-arabino uridine

2’-Deoxy-2’-fluoro-5-methyl-4’-thio-β-D-arabino uridine is a purine nucleoside analog that acts as a potent inhibitor of DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting nucleic acid metabolism. It is especially useful in cancer research for exploring therapeutic strategies and understanding the molecular mechanisms underlying tumor growth.

Cat. No.

A55435

CAS No.

109304-06-5

2’-Deoxy-2’-fluoroarabino-O6-methyl inosine

2’-Deoxy-2’-fluoroarabino-O6-methyl inosine is a purine nucleoside analog that exerts its biological activity primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor effects, making it particularly relevant in the study of indolent lymphoid malignancies. Its mechanisms of action include the induction of apoptosis, which further enhances its potential in cancer research applications.

Cat. No.

A55448

CAS No.

2763085-07-8

7-Cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-ribofuranosyl)guanine

7-Cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-ribofuranosyl)guanine is a purine nucleoside analog known for its anticancer properties. This compound exhibits significant biological activity against indolent lymphoid malignancies, primarily through the inhibition of DNA synthesis and the induction of apoptosis. It represents a valuable tool for research in cancer therapeutics and the study of purine metabolism.

Cat. No.

A55471

CAS No.

439579-24-5

3’-Deoxy-3’-fluoro-2-thiouridine

3’-Deoxy-3’-fluoro-2-thiouridine is a purine nucleoside analog known for its significant antitumor activity. It targets indolent lymphoid malignancies and exerts its effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool in cancer research, enabling studies on therapeutic strategies against various malignancies.

Cat. No.

A55481

CAS No.

39638-84-1

2-Methoxy-9-β-D-ribofuranosyl-9H-purine

2-Methoxy-9-β-D-ribofuranosyl-9H-purine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. This compound exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis in malignant cells. It is utilized in research focused on understanding and developing treatments for various lymphoid cancers.

Cat. No.

A55490

CAS No.

122723-92-6

1-Carboxyvinyl carboxyphosphonate

1-Carboxyvinyl carboxyphosphonate is a nucleoside metabolite that acts as a potent inhibitor of various nucleoside-related enzymes. It exhibits significant biological activity in modulating nucleotide metabolism, making it a valuable tool for studying metabolic pathways in cellular function and disease states. This reagent is useful for research applications in nucleoside metabolism and enzyme inhibition assays.

Cat. No.

A55501

CAS No.

172605-95-7

2’-β-C-Methyl-6-azauridine

2’-β-C-Methyl-6-azauridine is a purine nucleoside analog that exerts its effects primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the induction of apoptosis, making it a valuable reagent for cancer research and therapeutic studies focused on lymphoid tumors.

Cat. No.

A55518

CAS No.

152753-94-1

5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite

5'-O-DMT-2-thio-2'-dU-3'-phosphoramidite is a purine nucleoside analog that acts as a potent inhibitor of DNA synthesis. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting nucleotide incorporation during DNA replication. This compound is essential for research into cancer therapeutics and the development of novel DNA-targeting strategies.

Cat. No.

A55519

CAS No.

1093278-52-4

2-Methoxy-2’-deoxy-2’-fluoro-beta-D-arabinoadenosine

2-Methoxy-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine is a purine nucleoside analogue known for its antitumor properties. This compound exhibits significant activity against indolent lymphoid malignancies, primarily through the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. It is a valuable tool for research applications focused on cancer biology and therapeutic development.

Cat. No.

A55526

CAS No.

2305416-12-8

N3-Methyl-2’-O-(2-methoxyethyl)uridine

N3-Methyl-2’-O-(2-methoxyethyl)uridine is a uridine analog that acts as a competitive inhibitor of uridine metabolism. This compound exhibits potential antiepileptic properties and is utilized in research to investigate anticonvulsant and anxiolytic activities. Additionally, it is a valuable tool for the development of novel antihypertensive agents.

Cat. No.

A55531

CAS No.

1612192-05-8

2-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine

2-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and the development of therapeutic strategies targeting nucleic acid metabolism.

Cat. No.

A55532

CAS No.

5975-05-3

2′,3′-O-Isopropylideneisocytidine

2′,3′-O-Isopropylideneisocytidine is a purine nucleoside analog that exerts significant antitumor activity by targeting indolent lymphoid malignancies. This compound primarily functions through the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. Its unique mechanism highlights its potential in various therapeutic applications aimed at treating specific types of malignancies.

Cat. No.

A55533

CAS No.

2095417-31-3

4’,5’-Didehydro-2’-O-(2-methoxyethyl)-5-methyluridine

4’,5’-Didehydro-2’-O-(2-methoxyethyl)-5-methyluridine is a purine nucleoside analog that exerts its effects primarily through the inhibition of DNA synthesis. This compound demonstrates notable antitumor activity, particularly against indolent lymphoid malignancies, and induces apoptosis in cancer cells. Its applications in research provide valuable insights into the mechanisms of cancer treatment and therapeutic resistance.

Cat. No.

A55552

CAS No.

37805-90-6

5-Methoxy cytidine

5-Methoxy cytidine is a cytidine analog that functions primarily as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it valuable in cancer research and epigenetics studies. Its unique properties enable investigations into the regulatory roles of DNA methylation in various biological processes and diseases.

Cat. No.

A55594

CAS No.

771477-45-3

5'-dIMPS

5'-dIMPS is an analogue of 5'-dIMP that serves as a potential substrate, competitive inhibitor, or regulator of enzymes that interact with 5'-dIMP. Its structural similarity allows it to modulate enzymatic activities involved in nucleotide biosynthesis pathways. This compound can be utilized in biochemical studies to explore enzyme mechanisms and regulatory processes within cellular metabolism.

Cat. No.

A55601

CAS No.

87358-26-7

5'-dGMPS

5'-dGMPS is a 5'-dGMP analogue that serves as a potential substrate, competitive inhibitor, or regulator of enzymes that interact with 5'-dGMP. This reagent can be utilized in enzymatic assays to study the kinetics and mechanisms of nucleotide metabolism and signaling pathways. Research applications include investigating the role of 5'-dGMP in cellular processes and the development of therapeutic interventions targeting nucleotide-related pathways.