FAP

Cat. No.

A41637

CAS No.

3076328-74-7

FAP targeting peptide for FXX489

FAP targeting peptide for FXX489 is a polypeptide that specifically targets fibroblast activation protein (FAP). This ligand plays a crucial role in the development of therapeutic agents aimed at modulating FAP-related pathways. It is particularly applicable in cancer research, where FAP is associated with tumor stroma and cancer progression, facilitating targeted delivery of therapeutic compounds.

Cat. No.

A54842

CAS No.

2688118-55-8

OncoFAP-GlyPro-MMAE

OncoFAP-GlyPro-MMAE is a small molecule-drug conjugate (SMDC) targeting fibroblast activation protein (FAP) with an IC50 of 0.49 nM. This compound combines the selective FAP ligand OncoFAP with the tubulin inhibitor MMAE, linked for optimized delivery. OncoFAP-GlyPro-MMAE demonstrates significant cytotoxic activity and is suitable for research applications in renal cancer and related malignancies.

Cat. No.

A64616

CAS No.

2639365-69-6

OncoFAP

OncoFAP is a high-affinity ligand for fibroblast activation protein (FAP), designed for targeted applications in cancer research. Its pan-tumoral potential allows for effective identification and localization of tumors, aiding in the investigation of tumor microenvironments. This reagent is particularly useful in studies focused on cancer diagnostics and therapeutics, providing a valuable tool for enhancing the precision of tumor targeting.

Cat. No.

A64617

CAS No.

3076330-05-4

Unlabeled FXX489

Synonyms: NNS309

Unlabeled FXX489 is a fibroblast activation protein (FAP)-targeting ligand. This compound possesses anticancer properties and can be utilized in conjunction with isotopes such as 68Ga and 177Lu for imaging and therapeutic applications. Unlabeled FXX489 is particularly relevant for research on pancreatic ductal adenocarcinoma (PDAC), non-small cell lung cancer (NSCLC), breast cancer (BC), and colorectal cancer (CRC), aiding in the exploration of FAP's role in tumor biology and treatment strategies.

Cat. No.

A64621

CAS No.

2883407-81-4

FT-FAPI-12_9

FT-FAPI-12_9 is a fibroblast activation protein (FAP) ligand designed for the synthesis of FAPI-46, a radiotracer that selectively targets FAP. This compound exhibits specific binding properties that facilitate the imaging of tumors and inflammatory conditions associated with FAP expression. Its application in cancer research and molecular imaging underscores its utility in evaluating FAP as a potential therapeutic target.

Cat. No.

A64623

CAS No.

2374782-07-5

FAPI-34

FAPI-34 is a radiolabeled imaging agent that specifically targets fibroblast activation protein (FAP). It demonstrates high affinity for FAP-expressing cells, resulting in significant internalization and accumulation in FAP-positive tumor lesions while exhibiting minimal uptake in normal tissues, with the exception of the kidneys. This compound is particularly useful for tumor-related research applications, including imaging studies and the assessment of FAP's role in tumor biology.

Cat. No.

A88037

CAS No.

2230625-76-8

FAP Ligand 1

FAP Ligand 1 is a high-affinity small-molecule ligand that selectively targets fibroblast activation protein (FAP). This reagent is designed for conjugation with therapeutic agents, facilitating targeted delivery to FAP-expressing fibroblasts in cancer research. FAP Ligand 1 also has applications in radiation imaging studies, enhancing the visualization of tumors that express this biomarker.