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Toll-like Receptors

Toll-like receptor (TLR) agonists and inhibitors act on pattern recognition receptors of the innate immune system. A human homologue of the Drosophila Toll protein was shown in 1997 to signal activation of adaptive immunity. Each TLR recognizes particular microbial molecules, and mutations in mouse Tlr4 identified TLR4 as essential for lipopolysaccharide (LPS) signaling. The imidazoquinolines imiquimod and resiquimod activate immune cells through TLR7 and the adaptor myeloid differentiation primary response 88 (MyD88). Further agonists include GS-9620 for TLR7 and VTX-2337 for TLR8. Resatorvid and TLR2-IN-C29 inhibit TLR4 and TLR2 signaling, respectively, for studies of inflammation and host defense.

5 Items

  • Polyinosinic acid sodium
    Cat. No.
    A35279
    CAS No.
    33378-44-8

    Polyinosinic acid sodium

    Polyinosinic acid sodium is the sodium salt of polyinosinic acid, a single-stranded homonucleic acid that serves as a Toll-like Receptor 3 (TLR3) ligand. By activating TLR3, polyinosinic acid sodium enhances the cellular immune response through the TRIF signaling pathway. This reagent shows potential for use in studies focused on immune regulation and adjuvant therapies in various research applications.

    In stock View Details
    100 mg
    $20.00
    500 mg
    $40.00
    All 2 sizes
  • ODN 2007
    Cat. No.
    A35358
    CAS No.
    455348-63-7

    ODN 2007

    ODN 2007 is a class B CpG oligodeoxynucleotide (ODN) that functions as a Toll-like receptor (TLR) ligand. This compound serves as an effective immunomodulator and vaccine adjuvant, enhancing immune responses across a range of species, including mammals, fish, and humans. Its specific sequence is 5'-TCGTCGTTGTCGTTTTGTCGTT-3', making it a valuable tool for research applications in immunology and vaccine development.

    In stock View Details
    1 mg
    $65.00
    5 mg
    $115.00
    All 3 sizes
  • CRX 527
    Cat. No.
    A35448
    CAS No.
    216014-14-1

    CRX 527

    CRX 527 is a ligand of Toll-like receptor 4 (TLR4) that functions as an adjuvant for peptide-based cancer vaccines, demonstrating the ability to enhance anti-tumor immune responses. In addition to its immune-modulating properties, CRX 527 induces hematopoietic stem cell (HSC) differentiation, increases the number of Lin⁻Sca-1⁺c-Kit⁺ (LSK) cells, and promotes their differentiation into macrophages. This reagent activates immune defense mechanisms and provides protective effects on intestinal epithelium against radiation damage, making it valuable for cancer immunotherapy and research in regenerative medicine.

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    Out of stock

    All 3 sizes
  • Ste2Cys
    Cat. No.
    A35458
    CAS No.
    656831-19-5

    Ste2Cys

    Ste2Cys is a diacylglycerol cysteine-type lipid molecule that serves as a ligand for Toll-like Receptor 2 (TLR2). It activates the NF-κB signaling pathway, leading to the upregulation of MHC II class molecules on the surface of mouse bone marrow-derived dendritic cells. This compound is valuable for research into the development of immunologic vaccines and enhancing immune responses.

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    Out of stock

    All 3 sizes
  • 1Z105
    Cat. No.
    A35509
    CAS No.
    1438280-73-9

    1Z105

    1Z105 is a potent TLR4/MD2 ligand, known for its oral bioactivity. This compound promotes dendritic cell maturation and enhances antigen presentation, making it a valuable tool for studying immune responses. Additionally, 1Z105 has demonstrated therapeutic potential in preventing arthritis, contributing to research in autoimmune disease modulation and immune system regulation.

    In stock View Details
    25 mg
    $1,405.00
    50 mg
    $1,790.00
    All 3 sizes

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