Immunology & Inflammation related

Cat. No.

A39905

CAS No.

35661-60-0

Fmoc-leucine

Synonyms: N-FMOC-leucine; NPC 15199; NSC 334290

Fmoc-Leucine, an anti-inflammatory agent, functions primarily as a selective ligand for PPARγ, with a binding affinity (Ki) of 15 μM. It promotes both extracellular Ca2+ influx and intracellular Ca2+ release while exhibiting insulin-sensitizing effects with minimal fatogenic activity. This compound demonstrates unique self-assembly characteristics, forming transient gels, stable gels, or crystals/2D sheets under varying conditions. Fmoc-Leucine is valuable for research related to diabetes, colitis, and bladder cancer.

Cat. No.

A59478

CAS No.

501927-29-3

Anti-inflammatory agent 94

Anti-inflammatory agent 94 (compound 4b) is a potent cannabinoid ligand targeting the CB1 and CB2 receptors, exhibiting Kis of 29 nM and 8 nM, respectively. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for studying inflammation-related processes. Its application in research may enhance understanding of cannabinoid signaling and its therapeutic potential in inflammatory conditions.

Cat. No.

A64706

CAS No.

86401-95-8

Methylprednisolone aceponate

Synonyms: ZK 91588; MPA

Methylprednisolone aceponate is a glucocorticoid with a specific mechanism of action as a selective glucocorticoid receptor ligand, primarily functioning as an anti-inflammatory agent. It exhibits weak systemic effects, making it particularly useful in the treatment of localized inflammatory conditions. This compound is valuable for research applications targeting eczema and other inflammatory skin disorders, aiding in the understanding of their pathophysiology and potential treatments.