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IKZF Family

IKZF degraders remove Ikaros family zinc finger (IKZF) transcription factors of lymphocytes. Ikaros (IKZF1) was cloned in 1992 as an early lymphoid-specific transcription factor linked to T cell commitment. In 2014, two studies showed that lenalidomide recruits IKZF1 and Aiolos (IKZF3) to the cereblon (CRBN) E3 ubiquitin ligase for degradation. Lenalidomide hemihydrate, FPFT-2216 and MGD-28 act through this molecular glue mechanism. DEG-77 degrades Helios (IKZF2) together with casein kinase 1 alpha (CK1α). The section also holds cereblon-recruiting proteolysis targeting chimeras (PROTACs) such as BSJ-03-204, which degrades cyclin-dependent kinases 4 and 6 (CDK4, CDK6).

1 Item

  • USP3 ZnF-UBD ligand-1
    Cat. No.
    A64881
    CAS No.
    2419322-41-9

    USP3 ZnF-UBD ligand-1

    USP3 ZnF-UBD Ligand-1 is a small molecule that specifically targets the zinc finger ubiquitin-binding domain (ZnF-UBD) of USP3, exhibiting a binding affinity characterized by a KD of 14 μM. This ligand can be utilized in studies investigating the role of USP3 in ubiquitin signaling pathways and its implications in various diseases. Its ability to selectively bind to USP3 enables researchers to explore potential therapeutic strategies targeting this deubiquitinating enzyme.

    In stock View Details
    5 mg
    $245.00
    10 mg
    $405.00
    All 5 sizes

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