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NADPH Oxidase

NADPH oxidase (NOX) inhibitors block enzymes whose main role is to produce reactive oxygen species (ROS). These membrane enzymes move electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen, forming superoxide or hydrogen peroxide. The human family has seven members, NOX1 to NOX5 and dual oxidases 1 and 2 (DUOX1, DUOX2), which differ in tissue distribution and partner subunits. NOX2 is the phagocyte oxidase that supplies superoxide for microbial killing by neutrophils. Isoform-directed tools include ML 171 for NOX1, GSK2795039 for NOX2 and GLX351322 for NOX4, while GKT137831 inhibits both NOX1 and NOX4. Apocynin and diphenyleneiodonium chloride are older, broadly acting inhibitors, and diphenyleneiodonium also blocks flavoenzymes such as nitric oxide synthases.

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  • Saikosaponin bk1
    Cat. No.
    A76915
    CAS No.
    110352-77-7

    Saikosaponin bk1

    Saikosaponin bk1 is a specific binder for the dehydrogenase domain of NADPH oxidase 5 (NOX5), exhibiting hepatoprotective properties. It forms stable interactions with the NOX5 enzyme derived from Cylindrospermum stagnale, making it a valuable tool in studies of oxidative stress. This compound is particularly relevant in research focused on COVID-19 and alcoholic liver injury, contributing to the understanding of these conditions at a molecular level.

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