nAChR

Cat. No.

A67649

CAS No.

52829-07-9

BTMPS

BTMPS is a selective antagonist of the nicotinic acetylcholine receptor (nAChR). It has been shown to mitigate the adverse effects of morphine in animal models, making it a valuable tool for research into addiction and pain management therapies. Its role in modulating neurotransmitter systems presents opportunities for further studies in neuropharmacology and the development of novel therapeutic strategies.

Cat. No.

A67654

CAS No.

525596-64-9

bPiDI

bPiDI is a selective antagonist of the α6β2 nicotinic acetylcholine receptors (nAChRs). It effectively inhibits nicotine-evoked dopamine release in the striatum, making it a valuable tool for studying dopaminergic signaling pathways. This compound is particularly useful in research pertaining to nicotine addiction and dopamine-related disorders.

Cat. No.

A67656

CAS No.

2414674-70-5

Ropanicant

Synonyms: SUVN-911 free base

Ropanicant is a potent and selective antagonist of the neuronal nicotinic acetylcholine α4β2 receptor. This compound exhibits oral bioavailability, making it a valuable tool for investigating the role of α4β2 receptor modulation in depression research. Its properties facilitate studies focused on neuropharmacology and the development of therapeutic strategies targeting mood disorders.

Cat. No.

A67670

CAS No.

552-72-7

Lobelanidine

Lobelanidine is a selective antagonist of nicotinic acetylcholine receptors (nAChR), effectively inhibiting the α7 nAChR response as well as the α3β2/α3β4 nAChR responses, with IC50 values of 2.8 μM and 8.2 μM, respectively. This compound serves as a valuable tool for investigating the role of nAChRs in neuronal signaling and various neurological disorders. Its pharmacological properties make it suitable for research applications in neurobiology, drug discovery, and toxicology studies.

Cat. No.

A67673

CAS No.

2987393-37-1

nAChR antagonist 1

nAChR antagonist 1 is a selective antagonist of the α7 nicotinic acetylcholine receptor, exhibiting an IC50 value of 3.3 μM. This compound is valuable for studying the role of α7 nAChR in various neurological conditions, including schizophrenia, Alzheimer's disease, and inflammatory disorders. Its modulatory effects on neurotransmission make it a relevant tool for exploring therapeutic strategies in these disease contexts.

Cat. No.

A67679

CAS No.

21019-30-7

Methyllycaconitine

Synonyms: MLA

Methyllycaconitine is a selective competitive antagonist of the α7 nicotinic acetylcholine receptor (α7nAChR). It demonstrates significant neuroprotective effects by alleviating cytotoxicity induced by amyloid-β peptides in SH-SY5Y cells and mitigating methamphetamine-induced effects in the mouse striatum. Methyllycaconitine is a valuable tool for research into neurological disorders, including Alzheimer's disease.

Cat. No.

A67685

CAS No.

1340907-57-4

T761-0184

T761-0184 is a potent antagonist of the alpha-7 nicotinic acetylcholine receptor (nAChR). This compound effectively inhibits nAChR activity, making it a valuable tool for studying neurotransmission and synaptic plasticity. It holds potential for research applications in neurological disorders and offers insights into the mechanisms underlying cholinergic signaling.

Cat. No.

A67695

CAS No.

69-27-2

Chlorisondamine

Chlorisondamine is a nicotinic acetylcholine receptor antagonist that functions as a ganglionic blocker. It has been employed in studies to assess neurogenic factors influencing blood pressure and sympathetic vasomotor tone in animal models. Chlorisondamine exhibits antihypertensive properties, with significant effects on blood pressure, cardiac output, and heart rate, notably in murine experimental designs.

Cat. No.

A67702

CAS No.

1431628-22-6

(S)-UFR2709

(S)-UFR2709 is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), with a notable preference for the α4β2 subtype over α7. This compound exhibits anxiolytic properties, effectively reducing anxiety and lowering ethanol consumption and preference in alcohol-preferring rat models. (S)-UFR2709 serves as a valuable reagent for research into nicotine addiction and related behavioral studies.

Cat. No.

A67707

CAS No.

3114746-65-2

nAChR antagonist 3

nAChR antagonist 3 is a selective antagonist of the α7 nicotinic acetylcholine receptor, demonstrating an IC50 of 0.86 μM. It exhibits protective effects against toxicity induced by paraoxon, making it a valuable tool for studying organophosphate poisoning. This compound is suitable for research applications focusing on neuroprotection and receptor modulation associated with cholinergic signaling pathways.

Cat. No.

A67712

CAS No.

195966-93-9

(rel)-Asperparaline A

Synonyms: (rel)-Aspergillimide; (rel)-VM55598

(rel)-Asperparaline A is a potent antagonist of nicotinic acetylcholine receptors (nAChR), extracted from okara fermented with Aspergillus japonicas JV-23. This compound displays significant paralytic activity in silkworms, highlighting its potential as an anthelmintic agent. Its selectivity and effectiveness make it valuable for research applications focused on neurotransmission and parasitic control.

Cat. No.

A67731

CAS No.

23255-54-1

Dihydro-β-erythroidine

Dihydro-β-erythroidine is a competitive antagonist of nicotinic receptors, specifically targeting α4β2 subtypes. It effectively inhibits the discriminative stimulus properties associated with nicotine, as well as the anxiolytic effects induced by nicotine. This compound is widely utilized in neuropharmacological research to explore the role of nicotinic receptors in addiction, anxiety, and related behaviors.

Cat. No.

A67736

CAS No.

1150153-86-8

SR 16584

SR 16584 is a selective antagonist of the α3β4 nicotinic acetylcholine receptor (nAChR), exhibiting an IC50 value of 10.2 μM. This compound is utilized in research investigating the role of nAChRs in neurological disorders and potential therapeutic applications. Its specific inhibition of α3β4 nAChR makes it valuable for studying the receptor's involvement in neurotransmission and related signaling pathways.

Cat. No.

A67744

CAS No.

142021-80-5

ANQ9040

ANQ9040 is a steroidal relaxant that acts as a non-depolarizing nicotinic antagonist. It exhibits relatively low affinity for nicotinic receptors, making it suitable for investigating receptor function and characterizing neuromuscular mechanisms. This compound is primarily utilized in research applications related to muscle relaxation and neuromuscular transmission studies.

Cat. No.

A67752

CAS No.

1420777-30-5

Microgrewiapine A

Microgrewiapine A is a selective antagonist of nicotinic acetylcholine receptors (nAChR), specifically inhibiting human α4β2 and α3β4 subtypes with 60% and 70% efficacy, respectively. This compound demonstrates cytotoxic effects in HT-29 human colon cancer cells, exhibiting an IC50 value of 6.8 μM. Microgrewiapine A holds potential for research applications in cancer biology and neuropharmacology.

Cat. No.

A67757

CAS No.

107538-05-6

Dexmecamylamine

Synonyms: (+)-Mecamylamine; TC-5214

Dexmecamylamine is a selective antagonist of the nicotinic acetylcholine receptors (nAChR), specifically targeting the α3β4, α4β2, α7, and α1β1γδ subtypes with IC50 values in the micromolar range. This compound demonstrates notable anxiolytic and antidepressant-like effects, making it a valuable tool in neurological research and the study of mood disorders. Its ability to modulate nAChR activity positions it as a potential lead for therapeutic development in psychiatric conditions.