AMPK

Cat. No.

A43962

CAS No.

2252336-04-0

AMPK activator 16

AMPK activator 16 is a potent AMP-activated protein kinase (AMPK) activator that effectively enhances AMPK signaling. It promotes the phosphorylation of AMPK, subsequently increasing the levels of phosphorylated acetyl-CoA carboxylase (p-ACC) and phosphorylated raptor (p-raptor) in N2a cells. This compound is instrumental in studies exploring metabolic regulation and signaling pathways linked to energy homeostasis and cellular stress responses.

Cat. No.

A48109

CAS No.

14279-86-8

Galegine hemisulfate

Galegine hemisulfate is a guanidine derivative that functions as an AMPK activator. It has demonstrated potential in promoting weight loss in mice and effectively activates AMPK in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, Galegine hemisulfate exhibits antibacterial properties, with a minimum inhibitory concentration of 4 mg/L against strains of Staphylococcus aureus, making it relevant for various biological research applications.

Cat. No.

A48229

CAS No.

2368870-39-5

Galegine hydrochloride

Galegine hydrochloride is an AMPK activator that influences energy metabolism and contributes to weight management. Derived from the guanidine structure, this compound has shown efficacy in activating AMPK in various cell lines, including 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cells. Additionally, galegine hydrochloride exhibits antibacterial properties, demonstrating a minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains, highlighting its potential in metabolic and antimicrobial research applications.

Cat. No.

A54792

CAS No.

1990492-86-8

MARK-IN-4

MARK-IN-4 is a potent MARK inhibitor with an IC50 of 1 nM. It demonstrates significant biological activity in the regulation of microtubule dynamics, making it a valuable tool in Alzheimer's disease research. This compound allows for the investigation of MARK signaling pathways and their implications in neurodegenerative disorders.

Cat. No.

A57624

CAS No.

2377576-35-5

BAY-3827

BAY-3827 is a potent and selective inhibitor of AMP-activated protein kinase (AMPK), exhibiting IC50 values of 1.4 nM at low ATP concentrations (10 μM) and 15 nM at higher ATP concentrations (2 mM). This compound demonstrates over 500-fold selectivity against a wide array of kinases, making it a valuable tool for elucidating AMPK-related pathways. BAY-3827 effectively inhibits the phosphorylation of acetyl-CoA carboxylase 1 and displays significant anti-proliferative effects in androgen-dependent prostate cancer cell lines, supporting its application in cancer research and metabolic studies.

Cat. No.

A57625

CAS No.

2417674-27-0

AMPK-IN-3

AMPK-IN-3 is a potent and selective inhibitor of AMP-activated protein kinase (AMPK), exhibiting IC50 values of 60.7 nM for AMPK α2, 107 nM for AMPK α1, and 3820 nM for KDR. This compound effectively inhibits AMPK without impacting cell viability or inducing significant cytotoxicity in K562 cells. AMPK-IN-3 is valuable for research focused on cancer biology and the role of AMPK in metabolic regulation and cellular energy homeostasis.

Cat. No.

A57626

CAS No.

1852452-14-2

PF-739

PF-739 is a potent and orally active activator of AMP-activated protein kinase (AMPK). It effectively stimulates 12 heterotrimeric AMPK complexes, leading to a significant reduction in plasma glucose levels. This compound is utilized in research to investigate metabolic disorders and the cellular responses to energy stress. Its role as a non-selective AMPK activator makes it a valuable tool in studies focused on cellular metabolism and energy homeostasis.

Cat. No.

A57627

CAS No.

1422365-94-3

Lixumistat acetate

Synonyms: IM156; HL156A; HL271 acetate

Lixumistat acetate is a potent activator of AMP-activated protein kinase (AMPK), promoting increased phosphorylation of AMPK. This compound has demonstrated the ability to mitigate aging-related cognitive decline in animal models. Additionally, Lixumistat acetate acts as a strong inhibitor of oxidative phosphorylation (OXPHOS), making it a valuable tool for research in solid tumor applications.

Cat. No.

A57628

CAS No.

1066-30-4

Chromium(III) acetate

Synonyms: Chromium acetate; Chromic acetate; Chromium triacetate

Chromium(III) acetate functions as an AMPK inhibitor by inhibiting the phosphorylation of AMP-activated protein kinase (AMPK), subsequently promoting lipogenesis. This compound exhibits low toxicity in mammalian models, demonstrated by an LD50 of 2365 mg/kg in rats. It is primarily utilized in research to explore metabolic pathways and the regulation of energy homeostasis.

Cat. No.

A57630

CAS No.

1523493-53-9

PXL770

PXL770 is a selective allosteric activator of AMP-activated protein kinase (AMPK) that enhances metabolic regulation. It has been shown to decrease very long-chain fatty acid (VLCFA) levels, improve mitochondrial respiration, and modulate gene expression in proinflammatory pathways in fibroblasts and lymphocytes related to X-linked adrenoleukodystrophy (ALD). In animal models, PXL770 normalizes plasma VLCFA levels and improves metabolic parameters such as glycemia and insulin sensitivity in diet-induced obesity. This compound serves as a valuable tool for research into ALD, autosomal dominant polycystic kidney disease, and nonalcoholic steatohepatitis (NASH).

Cat. No.

A57633

CAS No.

2209854-03-3

MOTS-c (mouse)

MOTS-c (mouse) is a mitochondrial-derived polypeptide that acts as an AMPK activator. It has been shown to modulate pancreatic cell function by reducing insulin secretion and expression in INS-1E cells, while enhancing glucagon secretion in αTC-1 cells. Additionally, MOTS-c (mouse) is effective in decreasing apoptosis in both INS-1E and αTC-1 cell lines. Its ability to counteract diet-induced obesity and insulin resistance highlights its potential in metabolic research.

Cat. No.

A57636

CAS No.

1883548-91-1

ZLN024 hydrochloride

ZLN024 hydrochloride is an allosteric activator of AMP-activated protein kinase (AMPK). It selectively activates various AMPK heterotrimers, including AMPK α1β1γ1, α2β1γ1, α1β2γ1, and α2β2γ1, with EC50 values of 0.42 µM, 0.95 µM, 1.1 µM, and 0.13 µM, respectively. This compound is instrumental in studies related to energy homeostasis, metabolism, and cellular stress response, making it a valuable tool for researchers investigating AMPK-related pathways in various biological contexts.

Cat. No.

A57637

CAS No.

20633-93-6

Fortunellin

Fortunellin is a flavonoid that acts as an AMPK/Nrf2 activator, derived from the fruits of Fortunella margarita (kumquat). It demonstrates minimal toxicity in murine models and effectively reduces inflammation and reactive oxygen species (ROS) generation in H9C2 cells induced by lipopolysaccharide (LPS). By enhancing the AMPK/Nrf2 pathway, Fortunellin protects against fructose-induced inflammation and oxidative stress, making it a valuable tool for research in diabetic cardiomyopathy.

Cat. No.

A57638

CAS No.

873077-70-4

AMPK-IN-4

AMPK-IN-4 is a selective inhibitor of AMP-activated protein kinase (AMPK), targeting both AMPKα1 and AMPKα2 with IC50 values of 393 nM and 141 nM, respectively. This compound is significant in cancer research, facilitating investigations into metabolic regulation and cellular energy homeostasis. Its efficacy in modulating AMPK activity makes it a valuable tool for studying the pathways associated with tumor metabolism and potential therapeutic strategies.

Cat. No.

A57639

CAS No.

331002-70-1

PT1

PT1 is an activator of AMPKα1, specifically designed to directly activate the inactive truncated forms of AMPKα1 monomers. This compound enhances AMPK signaling, which plays a critical role in cellular energy homeostasis and metabolism. PT1 is valuable for research applications investigating metabolic disorders, cellular response to stress, and the regulatory mechanisms of energy balance.

Cat. No.

A57640

CAS No.

125911-68-4

SAMS

SAMS peptide is a specific substrate for AMP-activated protein kinase (AMPK), facilitating the investigation of AMPK activation and its downstream signaling pathways. This peptide plays a critical role in metabolic research, allowing for the study of energy homeostasis and cellular responses to stress. SAMS is essential for probing the physiological effects of AMPK modulation in various biological contexts.

Cat. No.

A57641

CAS No.

1422365-52-3

Lixumistat hydrochloride

Synonyms: HL271; IM156 hydrochloride; HL156A hydrochloride

Lixumistat hydrochloride is a potent AMPK activator that increases AMPK phosphorylation, thereby modulating critical metabolic pathways. This compound has been shown to mitigate aging-associated cognitive impairment in animal models, making it a valuable tool in neurobiology research. Additionally, Lixumistat hydrochloride acts as an effective oxidative phosphorylation (OXPHOS) inhibitor, relevant for studies focusing on solid tumors.

Cat. No.

A57642

CAS No.

1467059-70-6

PF-06685249

Synonyms: PF-249

PF-06685249 is a potent allosteric activator of AMP-activated protein kinase (AMPK), exhibiting an EC50 of 12 nM for recombinant AMPK α1β1γ1. This compound has demonstrated efficacy in enhancing renal function in ZSF-1 rats with diabetic nephropathy. PF-06685249 is suitable for research applications targeting metabolic diseases and diabetic nephropathy.

Cat. No.

A57644

CAS No.

73439-19-7

COH-SR4

COH-SR4 is a potent AMPK activator that exhibits significant anti-proliferative effects against various cancers, including leukemia, melanoma, breast, and lung cancers. By activating AMPK, COH-SR4 inhibits adipocyte differentiation, making it a valuable tool for studying obesity and related metabolic disorders. This compound is crucial for research aimed at understanding metabolic regulation and the therapeutic potential of targeting AMPK in cancer and metabolic diseases.

Cat. No.

A57645

CAS No.

1233082-79-5

Ampkinone

Ampkinone is an indirect activator of AMP-activated protein kinase (AMPK), targeting metabolic pathways involved in energy homeostasis. It enhances AMPK activity, which plays a crucial role in regulating cellular energy balance, glucose uptake, and lipid metabolism. This compound is valuable in research applications focused on metabolic disorders, obesity, and diabetes, offering insights into therapeutic strategies for these conditions.

Cat. No.

A57647

CAS No.

3056005-98-9

ALKBH1-IN-3 prodrug

ALKBH1-IN-3 prodrug is a potent inhibitor of the DNA N6-methyladenine demethylase ALKBH1, functioning primarily through modulation of the AMPK signaling pathway. This prodrug significantly enhances the cellular abundance of 6mA, leading to a reduction in the viability of gastric cancer cells. With its strong cellular activity and favorable in vivo metabolic profile, ALKBH1-IN-3 prodrug is a valuable tool for investigating mechanisms underlying gastric cancer and the role of epigenetic modifications in tumor biology.

Cat. No.

A57648

CAS No.

3036759-47-1

PF-07293893

PF-07293893 is an AMPKγ3 activator that enhances cellular energy homeostasis. This compound increases glycogen content, improves lipid oxidation, enhances mitochondrial biogenesis, and promotes vascular repair. It is particularly useful in research applications related to heart failure and metabolic disorders.

Cat. No.

A57649

CAS No.

2493239-46-4

AMPK activator 4

AMPK Activator 4 is a selective activator of AMP-activated protein kinase (AMPK) that does not inhibit mitochondrial complex I. This compound enhances AMPK activity specifically in muscle tissues, demonstrating a dose-dependent improvement in glucose tolerance in normal mice. Furthermore, it significantly reduces fasting blood glucose levels and ameliorates insulin resistance in db/db diabetic mice, showcasing its potential as an anti-hyperglycemic agent for diabetes research.

Cat. No.

A57650

CAS No.

1238116-48-7

Kazinol U

Kazinol U functions as an AMP kinase inhibitor, effectively modulating cellular energy homeostasis. It demonstrates significant activity in inhibiting melanogenesis by targeting tyrosinase-related proteins through AMPK pathway activation. This compound is valuable for research applications focused on skin pigmentation, metabolic regulation, and the therapeutic development of hyperpigmentation disorders.

Cat. No.

A57651

CAS No.

431920-24-0

AMPK activator 12

AMPK Activator 12 is a potent activator of AMP-activated protein kinase (AMPK) and serves as an inducer of growth differentiation factor 15 (GDF15). This compound significantly elevates GDF15 protein levels in human hepatic cells, making it a valuable tool for research into metabolic regulation and cellular stress responses. Its ability to modulate these pathways positions AMPK Activator 12 as a crucial reagent for studies on obesity, diabetes, and related metabolic disorders.