AMPK

Cat. No.

A57652

CAS No.

1152423-98-7

AMPK activator 1

AMPK Activator 1 is a potent activator of AMP-activated protein kinase (AMPK), demonstrating an EC50 of less than 0.1 μM. This compound facilitates the phosphorylation of AMPK, thereby enhancing its activity and promoting cellular energy homeostasis. AMPK Activator 1 is valuable for research applications in metabolism, obesity, diabetes, and cancer studies, where modulation of AMPK signaling pathways may provide therapeutic insights.

Cat. No.

A57653

CAS No.

1219739-95-3

AMPK-IN-1

AMPK-IN-1 is a potent activator of AMP-activated protein kinase (AMPK), specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM. This compound facilitates the phosphorylation of eEF2 through a mechanism that is independent of mTORC1 signaling. AMPK-IN-1 is valuable for research into metabolic regulation and the cellular energy response, offering insights into the therapeutic potential for conditions related to energy imbalances.

Cat. No.

A57654

CAS No.

3096082-93-5

UCB9386

UCB9386 is a selective inhibitor of Nuak1, exhibiting strong brain penetration with an average pIC50 of 10.1. This compound also inhibits Nuak2 and Kak2, achieving approximately 50% inhibition at a concentration of 10 nM. UCB9386 is suitable for research applications involving metabolic regulation and neurobiology, providing valuable insight into the roles of AMP-activated protein kinases in cellular processes.

Cat. No.

A57655

CAS No.

1343402-73-2

3α-Hydroxymogrol

3α-Hydroxymogrol is a triterpenoid derived from Siraitia grosvenorii Swingle, recognized for its ability to activate AMP-activated protein kinase (AMPK). This compound promotes phosphorylation of AMPK, which plays a critical role in cellular energy homeostasis. Research applications include studying metabolic disorders, energy regulation, and potential therapeutic effects in obesity and diabetes.

Cat. No.

A57658

CAS No.

2415643-79-5

IQZ23

IQZ23 is an AMPK activator that inhibits adipocyte differentiation through the activation of the AMPK pathway. It demonstrates potent efficacy in reducing triglyceride levels, with an EC50 of 0.033 μM in 3T3-L1 adipocytes. This compound is relevant for research into obesity and associated metabolic disorders, making it a valuable tool for studying metabolic regulation.

Cat. No.

A57659

CAS No.

1190602-80-2

AMPK/mTOR modulator-1

AMPK/mTOR modulator-1 is a Ginsenoside derivative functioning as both an mTOR inhibitor and AMPK activator. It activates AMPK signaling with a Kd of 4.759 μM, promoting M1-like tumor-associated macrophage polarization while inhibiting M2-like polarization. This compound enhances glycolysis and demonstrates significant anti-inflammatory activity alongside inhibition of tumor progression. AMPK/mTOR modulator-1 is ideal for research focused on colorectal cancer and related metabolic disorders.

Cat. No.

A57661

CAS No.

1858204-23-5

AMPK activator 9

AMPK Activator 9 (ZM-6) is a potent activator of AMP-activated protein kinase (AMPK) with an EC50 value of 1.1 µM, primarily targeting the α2β1γ1 subunit. This compound demonstrates significant biological activity in energy metabolism modulation and has applications in research focused on type 2 diabetes. It serves as a valuable tool for elucidating AMPK-related pathways and therapeutic strategies for metabolic disorders.

Cat. No.

A57662

CAS No.

1852451-96-7

AMPK activator 8

AMPK activator 8 is a potent activator of AMP-activated protein kinase (AMPK), demonstrating EC50 values of 11, 27, 4, 2, and 4 nM for various AMPK isoforms: rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, and rAMPK α2β2γ3. This compound is particularly valuable for studying metabolic disorders, specifically type 2 diabetes, by enhancing AMPK activity and modulating glucose metabolism. Its high specificity and efficacy make it an important tool for researchers exploring AMPK-related pathways and therapeutic interventions.

Cat. No.

A57663

CAS No.

189299-03-4

AMPK activator 6

AMPK Activator 6 is a potent activator of AMP-activated protein kinase (AMPK) that enhances its signaling pathway in HepG2 and 3T3-L1 cells. This compound effectively reduces lipid accumulation by significantly lowering triglyceride (TG), total cholesterol (TC), and low-density lipoprotein-C (LDL-C) levels in serum. AMPK Activator 6 is valuable for research into non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome, making it a critical tool for investigating metabolic disorders.

Cat. No.

A57666

CAS No.

1914176-03-6

AMPK activator 10

AMPK Activator 10 is a potent activator of AMP-activated protein kinase (AMPK) with an effective concentration (EC150) of 44.3 nM as determined by cell-ELISA. This compound enhances phosphorylation of acetyl-CoA carboxylase (ACC), contributing to its biological effects. AMPK Activator 10 has demonstrated glucose-lowering properties, making it a valuable tool for research in metabolic regulation and related disorders.

Cat. No.

A57667

CAS No.

16722-44-4

JJO-1

JJO-1 is an activator of AMP-activated protein kinase (AMPK) with an EC50 of 1.8 μM. This compound is valuable for research into metabolic disorders, particularly obesity and type 2 diabetes, as it modulates energy homeostasis and enhances glucose uptake. JJO-1 provides a tool for scientists investigating therapeutic strategies aimed at metabolic regulation and improving insulin sensitivity.

Cat. No.

A57669

CAS No.

2711012-08-5

CB1R/AMPK modulator 1

CB1R/AMPK Modulator 1 is a potent modulator of the cannabinoid receptor type 1 (CB1R) and adenosine monophosphate-activated protein kinase (AMPK), exhibiting a Ki of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound effectively activates AMPK, leading to significant reductions in food intake and body weight. Additionally, it enhances glucose tolerance and insulin sensitivity, making it a valuable tool for research in metabolic disorders and obesity-related studies.

Cat. No.

A57670

CAS No.

2939087-00-8

DBI-2

DBI-2 is an AMPK activator that targets mitochondrial complex I. It disrupts oxidative phosphorylation (OXPHOS), leading to a reduction in ATP generation within mitochondria. DBI-2 demonstrates significant inhibitory effects on the proliferation of colorectal cancer (CRC) cells, making it a valuable tool for investigating metabolic dysregulation in cancer research.

Cat. No.

A57671

CAS No.

1644498-53-2

BI-9774

BI-9774 is a potent activator of 5' AMP-activated protein kinase (AMPK), with an IC50 ranging from 12 to 88 nM. This compound is primarily utilized in research focused on metabolic disorders, such as type 2 diabetes and obesity, as well as in cardiovascular disease studies, including myocardial ischemia and heart failure. Its ability to modulate AMPK activity makes it a valuable tool for investigating therapeutic strategies in these areas.

Cat. No.

A57672

CAS No.

2410961-69-0

AMPK activator 2

AMPK Activator 2, a fluorine-containing proguanil derivative, targets the AMP-activated protein kinase (AMPK) signaling pathway, enhancing its activation while downregulating the mTOR/4EBP1/p70S6K pathway. This compound exhibits significant anti-proliferative and anti-migratory effects on various human cancer cell lines, including UMUC3, T24, and A549. AMPK Activator 2 is valuable for research focused on cancer metabolism and therapeutic strategies aimed at metabolic regulation in oncology.

Cat. No.

A57675

CAS No.

1356632-18-2

AMPK activator 14

AMPK activator 14 is a selective activator of AMP-activated protein kinase (AMPK). This compound has demonstrated the ability to lower fasted glucose and insulin levels in a db/db mouse model of Type II diabetes. It serves as a valuable tool for research into metabolic disorders and the mechanisms of diabetes management.

Cat. No.

A57676

CAS No.

1943510-86-8

AMPK-α1β1γ1 activator 1

AMPK-α1β1γ1 activator 1 is a selective agonist for the AMPK-α1β1γ1 isoform, exhibiting an EC50 value of 38.1 nM. This compound serves as an acyl glucuronide metabolite of an Indole-3-carboxylic acid-based AMPK activator and demonstrates direct binding to the human AMPK complex. Its biological activity makes it a valuable tool for research into metabolic disorders such as diabetic nephropathy.

Cat. No.

A57678

CAS No.

528-64-3

Galbacin

Synonyms: (3S)-Zuonin A

Galbacin, an AMPK activator, plays a crucial role in regulating cellular energy homeostasis. Isolated from Myristica fragrans (nutmeg), Galbacin effectively stimulates the AMPK enzyme in differentiated C2C12 cells, demonstrating notable anti-cancer properties by inhibiting the proliferation of lymphocytes and tumor cells. Additionally, it shows promise in preventing weight gain in diet-induced mice models, making it relevant for research into metabolic syndromes, including obesity and type 2 diabetes, as well as cancer studies.

Cat. No.

A57679

CAS No.

849727-81-7

D942

D942 is a potent activator of AMP-activated protein kinase (AMPK) that effectively penetrates cell membranes. This compound also exhibits partial inhibition of mitochondrial complex I. D942 has demonstrated significant anti-proliferative effects on multiple myeloma cells, making it a valuable tool for studies focusing on energy metabolism and cancer cell growth regulation. 연구 응용: D942 can be utilized in investigations of AMPK signaling pathways and their role in cancer metabolism.

Cat. No.

A57681

CAS No.

1623138-03-3

AMPK activator 7

AMPK Activator 7 (compound I-3-24) is a potent activator of AMP-activated protein kinase (AMPK) with an EC50 value of 8.8 nM. This compound is valuable for investigating diseases linked to AMPK dysregulation, including type 2 diabetes, metabolic syndrome, obesity, hyperglycemia, hypercholesterolemia, and hypertension. Its selective activation of AMPK facilitates research into metabolic regulation and potential therapeutic interventions for these conditions.

Cat. No.

A57682

CAS No.

2948304-00-3

AMPK activator 11

AMPK Activator 11 is a potent activator of AMP-activated protein kinase (AMPK) with nanomolar antiproliferative activity against various colorectal cancers (CRCs). By selectively activating AMPK, this compound enhances oxidative phosphorylation (OXPHOS) and inhibits the growth of RKO xenografts. AMPK Activator 11 is valuable for research in anti-tumor mechanisms and metabolic disease pathways.

Cat. No.

A57684

CAS No.

3019920-38-5

4-PivO-NMT chloride

4-PivO-NMT chloride is an indole-derived modulator of the AMPK signaling pathway, specifically influencing neurogenesis and neurite outgrowth by regulating AMPK activity. Its biological activity suggests potential applications in studying neurological disorders, pain mechanisms, and inflammatory responses. This compound serves as a valuable tool for researchers investigating the role of AMPK in various cellular processes.

Cat. No.

A57685

CAS No.

28028-62-8

Ethyl (E)-ferulate

Ethyl (E)-ferulate is an activator of the AMPK/Nrf2 signaling pathway, demonstrating significant potential in reducing acute lung injury induced by lipopolysaccharide. This compound exhibits antioxidant and free radical scavenging properties, contributing to its anti-inflammatory and neuroprotective effects. Ethyl (E)-ferulate is a valuable tool for research focused on inflammation and neurodegenerative diseases.

Cat. No.

A57686

CAS No.

1428422-55-2

AMPK activator C2

AMPK activator C2 is a potent allosteric activator of AMP-activated protein kinase (AMPK). It enhances AMPK activity, which plays a critical role in cellular energy homeostasis and metabolic regulation. This compound is valuable for investigating the mechanisms underlying epilepsy and convulsions, contributing to the understanding of neuroenergetics and potential therapeutic approaches.

Cat. No.

A57688

CAS No.

1888473-12-8

IND 1316

IND 1316 is an orally active AMPK activator that effectively crosses the blood-brain barrier. It exhibits neuroprotective properties in preclinical models of Huntington's disease and is applicable in research concerning neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. This compound serves as a valuable tool for investigating AMPK-related pathways and therapeutic strategies in neurological diseases.