AMPK

Cat. No.

A11071

CAS No.

844499-71-4

A-769662

A-769662 is a new activator of AMP-activated protein kinase (AMPK).

Cat. No.

A10028

CAS No.

2627-69-2

Acadesine (Aicar, NSC 105823)

Synonyms: AICA-riboside; Aicar; NSC 105823

Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.

Cat. No.

A11622

CAS No.

657-24-9

Metformin

Synonyms: 1,1-Dimethylbiguanide

Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.

Cat. No.

A16795

CAS No.

1219739-36-2

ex229 (compound 991)

Synonyms: compound 991

EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.

Cat. No.

A13392

CAS No.

1394371-71-1

MK8722

MK8722 is a potent and systemic pan-AMPK activator.

Cat. No.

A15571

CAS No.

117-10-2

Danthron

Synonyms: Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

Danthron is an AMPK activator that plays a critical role in regulating glucose and lipid metabolism. Derived from the traditional Chinese medicinal plant Salvia miltiorrhiza Bunge, Danthron has demonstrated potential in enhancing cellular energy balance. Its biological activity makes it a valuable reagent for research in metabolic disorders and related therapeutic applications.

Cat. No.

A16284

CAS No.

1273323-67-3

YLF-466D

Synonyms: C24

YLF-466D is an allosteric AMPK activator.

Cat. No.

A16801

CAS No.

1467057-23-3

PF-06409577

PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.

Cat. No.

A17063

CAS No.

1219737-12-8

MK-3903

MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 exhibited robust target engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin sensitization in mice.

Cat. No.

A17097

CAS No.

1621-56-3

7-Methoxyisoflavone

7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).

Cat. No.

A19807

CAS No.

1261289-04-6

O-304

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK.

Cat. No.

A21963

CAS No.

723249-01-2

ZLN024

ZLN024 is an AMPK allosteric activator.

Cat. No.

A22320

CAS No.

1422365-93-2

IM156

IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation.

Cat. No.

A22339

CAS No.

1640294-30-9

ASP4132

ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models.

Cat. No.

A22484

CAS No.

1467059-66-0

PF-06679142

Synonyms: PF-6679142

PF-06679142 is a potent AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption, low plasma clearance, and negligible renal clearance in preclinical species.

Cat. No.

A26035

CAS No.

81474-59-1

Candidusin A

Synonyms: CHNQD-0803

Candidusin A is a potent AMPK activator with a KD of 47.28 nM, isolated from the marine fungus Aspergillus candidus. This compound demonstrates significant cytotoxicity, inducing apoptosis in human prostate cancer cell lines such as 22Rv1, PC-3, and LNCaP. Additionally, Candidusin A reduces the expression of adipogenesis-related genes and fat deposition, while negatively regulating the NF-κB-TNFα inflammatory axis to mitigate inflammation. Its diverse biological activities make Candidusin A a valuable tool for research into non-alcoholic steatohepatitis (NASH) and liver injury.

Cat. No.

A30698

CAS No.

1179347-65-9

MT 63-78

MT 63-78 is a specific and potent direct activator of AMP-activated protein kinase (AMPK), exhibiting an EC50 value of 25 μM. This compound not only induces cell mitotic arrest and apoptosis but also effectively inhibits prostate cancer growth through the suppression of lipogenesis and the mTORC1 signaling pathway. MT 63-78 demonstrates significant antitumor effects, making it a valuable reagent for cancer research applications focused on metabolic regulation and cell cycle modulation.

Cat. No.

A32395

CAS No.

1178583-19-1

GL-V9

GL-V9 is an AMPK activator that modulates cellular metabolism and promotes apoptosis in HepG2 cells, with an IC50 of 35.2 μM. It induces cell cycle arrest at the G2/M phase and alters mitochondrial membrane potential, leading to increased intracellular reactive oxygen species. By inhibiting the pentose phosphate pathway and enhancing fatty acid oxidation via AMPK activation, GL-V9 significantly impedes cancer cell metastasis and demonstrates antitumor efficacy in mouse models, making it a valuable tool for cancer research.

Cat. No.

A32724

CAS No.

18251-36-0

Thalidezine

Thalidezine is a selective activator of AMP-activated protein kinase (AMPK), a crucial regulator of cellular energy homeostasis. It has been shown to promote autophagic cell death in anti-apoptotic cancer cells by modulating energy metabolism. Thalidezine serves as a valuable tool for investigating the mechanisms of apoptosis and potential therapeutic interventions in cancer research.

Cat. No.

A36087

CAS No.

165133-85-7

NFAT-133

NFAT-133 is an aromatic polyketide that functions as an AMPK activator. It enhances glucose uptake in muscle cells, showing potential as an antidiabetic agent. Additionally, NFAT-133 suppresses T-cell proliferation and IL-2 expression by inhibiting the transcriptional activity of nuclear factor of activated T-cells (NFAT), exhibiting immunosuppressive properties. This compound also reduces nitric oxide production in RAW264.7 cells stimulated by lipopolysaccharide (LPS), without displaying antibacterial or cytotoxic effects.

Cat. No.

A36503

CAS No.

140405-36-3

RSVA405

RSVA405 is a potent, orally bioavailable activator of AMP-activated protein kinase (AMPK), exhibiting an EC50 of 1 μM. This compound enhances CaMKKβ-mediated activation of AMPK, leading to the inhibition of mTOR and promotion of autophagy, which in turn increases the degradation of amyloid beta (Aβ). Additionally, RSVA405 demonstrates anti-inflammatory properties by inhibiting STAT3 activity, and is applicable in obesity research.

Cat. No.

A37027

CAS No.

2170935-59-6

HSF1/AMPK activator 1

HSF1/AMPK activator 1 is a potent modulator of the HSF1/AMPK axis, targeting the TGF-β1/Smad signaling pathway. This compound demonstrates significant anti-hepatic fibrosis activity by inhibiting fibrosis formation and cell proliferation in activated hepatic stellate cells. Additionally, HSF1/AMPK activator 1 effectively alleviates liver injury and symptoms of hepatic fibrosis in fibrotic mouse models. It is a valuable tool for research focused on hepatic fibrosis and related metabolic disorders.

Cat. No.

A37153

CAS No.

503-74-2

Isovaleric acid

Isovaleric acid is an AMPK activator known for its role in inhibiting osteoclast differentiation through the stimulation of AMPK phosphorylation. Additionally, it promotes colonic smooth muscle relaxation via the activation of the cAMP/PKA pathway. This compound is applicable in research focusing on skeletal diseases, including osteoporosis, as well as intestinal disorders.

Cat. No.

A39463

CAS No.

28500-04-1

Malvidin-3-O-arabinoside chloride

Malvidin-3-O-arabinoside chloride is an AMPK inducer that enhances cellular autophagy. This compound is recognized for its ability to mitigate oxidative damage induced by ethyl carbamate through the activation of AMPK signaling pathways. Its biological activity supports research applications focused on metabolic disorders and oxidative stress-related conditions.

Cat. No.

A39621

CAS No.

1290069-19-0

OSU-53

OSU-53 is an orally active AMPK activator and a direct mTOR inhibitor, exhibiting an EC50 of 0.3 μM. This compound induces autophagy by facilitating the conversion of LC3 I to LC3 II and plays a crucial role in modulating energy homeostasis by downregulating fatty acid biosynthesis while enhancing oxidative metabolism through upregulation of PGC1α and NRF-1. OSU-53 demonstrates antitumor activity across various cancer models, including breast and thyroid cancers, making it a valuable tool for cancer research and metabolic studies.