Factor Xa

Cat. No.

A10800

CAS No.

366789-02-8

Rivaroxaban

Synonyms: BAY 59-7939; Xarelto

Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex.

Cat. No.

A10082

CAS No.

503612-47-3

Apixaban (BMS-562247-01)

Synonyms: BMS-562247-01

Apixaban is an anticoagulant for the prevention of venous thromboembolism and venous thromboembolic events.

Cat. No.

A11517

CAS No.

193153-04-7

Otamixaban (FXV 673)

Synonyms: FXV 673

Otamixaban(FXV 673) is an intravenous direct factor Xa inhibitor.

Cat. No.

A14317

CAS No.

1229194-11-9

Edoxaban (tosylate Monohydrate)

Synonyms: DU-176b

Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM

Cat. No.

A18015

CAS No.

480449-70-5

Edoxaban

Synonyms: DU-176

Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

Cat. No.

A10158

CAS No.

280118-23-2

BMS-740808

BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.

Cat. No.

A12154

CAS No.

226566-43-4

RWJ-445167

Synonyms: 3DP-10017

RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

Cat. No.

A12518

CAS No.

330942-05-7

Betrixaban

Synonyms: PRT-054,021; PRT-054021

Betrixaban is an anticoagulant drug which acts as a direct factor Xa inhibitor. It is potent, orally active and highly selective for factor Xa, being selected from a group of similar compounds for its low hERG affinity.

Cat. No.

A12870

CAS No.

218298-21-6

Razaxaban

Razaxaban is a selective, potent, and orally bioavailable inhibitor of coagulation factor Xa.

Cat. No.

A12871

CAS No.

870262-90-1

Letaxaban (TAK-442)

Synonyms: TAK 442

Letaxaban, also known as TAK-442, is a potent, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. TAK-442 inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442] and rat (IC(50): 32 nM, TAK-442) plasma.

Cat. No.

A14099

CAS No.

292135-59-2

DPC-423

DPC423 is a highly potent and orally bioavailable pyrazole antithrombotic agent.

Cat. No.

A14979

CAS No.

865479-71-6

5-R-Rivaroxaban

Synonyms: Xarelto; BAY 59-7939

5-R-Rivaroxaban is (R) enantiomer of Rivaroxaban. Rivaroxaban is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders.

Cat. No.

A15076

CAS No.

480449-71-6

Edoxaban tosylate

Synonyms: DU-176b

Edoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

Cat. No.

A17617

CAS No.

936539-80-9

Betrixaban maleate

Synonyms: PRT054021 maleate

Betrixaban maleate is a highly selective and potent inhibitor of factor Xa (fXa), demonstrating an IC50 of 1.5 nM. This compound exhibits significant antithrombotic activity, making it valuable for research into anticoagulant therapies. Betrixaban maleate is suitable for studies focused on thrombosis, cardiovascular diseases, and hemostatic regulation.

Cat. No.

A17918

CAS No.

114870-03-0

Fondaparinux Sodium

Synonyms: Fondaparinux sodium salt; PENTA; Arixtra; Xantidar; SR 90107A; IC-85158

Fondaparinux sodium is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII).

Cat. No.

A49299

CAS No.

149358-73-6

ChloraMine-T hydrate

Synonyms: Sodium chloro(4-methylbenzenesulfonyl)azanide hydrate

ChloraMine-T hydrate is a selective Factor Xa inhibitor known for its utility in synthetic chemistry. It serves as a versatile reagent in aminohydroxylation and allylic amination reactions, functioning as a nitrogen source in the aziridination of alkenes and facilitating the deprotection of sulfur groups in thiol-containing compounds. Additionally, ChloraMine-T hydrate exhibits antimicrobial properties, demonstrating efficacy against various bacterial strains, including Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and Enterococcus cloacae, making it valuable for applications in both enzymatic inhibition studies and antimicrobial research.

Cat. No.

A64984

CAS No.

209957-47-1

DPC423 free base

DPC423 free base is a selectively potent Factor Xa inhibitor, demonstrating inhibition constants (Kis) of 0.15 nM in humans and 0.3 nM in rabbits. It exhibits moderate selectivity with Kis of 60 nM against human trypsin, 61 nM against plasma kallikrein, and 6000 nM against thrombin. By inhibiting the formation of the prothrombinase complex, DPC423 reduces thrombin generation, thereby obstructing fibrin formation and platelet activation. This compound is valuable for research applications related to anticoagulation in arterial thrombosis.

Cat. No.

A69887

CAS No.

288079-93-6

BMS-344577

BMS-344577 is a potent, orally active factor Xa inhibitor with an IC50 of 4 nM, demonstrating significant efficacy in anticoagulation research. This compound also exhibits strong CYP3A4 inhibition with an IC50 of 0.3 μM. BMS-344577 is primarily utilized in studies related to cardiovascular disease, facilitating the exploration of therapeutic interventions targeting coagulation pathways.

Cat. No.

A74693

CAS No.

229336-92-9

ZK-813039

ZK-813039 is a potent, orally active inhibitor of factor Xa, a key enzyme in the coagulation cascade. It effectively prolongs prothrombin time, making it a valuable tool in the study of anticoagulation mechanisms. This compound is primarily utilized in cardiovascular disease research, contributing to the development of novel therapeutic approaches for managing thrombotic disorders.

Cat. No.

A74694

CAS No.

288077-60-1

BMS-269223

BMS-269223 is a potent and selective orally active inhibitor of factor Xa, demonstrating a Ki value of 6.5 nM and an effective concentration for 2x prothrombin time prolongation of 32 μM. This compound plays a crucial role in inhibiting thrombosis formation, making it an important tool for cardiovascular disease research. BMS-269223 facilitates the study of anticoagulant therapies and the underlying mechanisms of thrombotic disorders.

Cat. No.

A74696

CAS No.

80895-10-9

CH3OCO-D-CHA-Gly-Arg-pNA acetate

CH3OCO-D-CHA-Gly-Arg-pNA acetate is a chromogenic substrate specifically designed for the enzymatic activity of Factor Xa. Upon cleavage by Factor Xa, it releases p-nitroaniline, which can be quantitatively measured to assess enzymatic function. This compound is valuable for studies involving coagulation cascades and is commonly used in research applications focused on thrombosis and hemostasis.

Cat. No.

A74702

CAS No.

1438492-26-2

Ciraparantag

Synonyms: PER977

Ciraparantag is a potent inhibitor of thrombin and factor Xa, serving as a broad-spectrum reversal agent for various anticoagulants. This compound effectively neutralizes the effects of low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants, while sparing vitamin K antagonists and argatroban. Its unique mechanism makes Ciraparantag a valuable tool for research focused on anticoagulation reversal and hemostasis.

Cat. No.

A74705

CAS No.

1415566-28-7

Dechloro Rivaroxaban

Dechloro Rivaroxaban is a potent, selective inhibitor targeting Factor Xa, demonstrating a Ki of 0.4 nM against human free FXa. This compound effectively inhibits prothrombinase activity and fibrin-associated FXa activity, exhibiting IC50 values of 2.1 nM and 92 nM, respectively. Dechloro Rivaroxaban is suitable for research applications focused on coagulation and antithrombotic drug development.

Cat. No.

A74709

CAS No.

1644388-83-9

Ciraparantag acetate

Synonyms: PER977 acetate

Ciraparantag acetate is a potent inhibitor of thrombin and factor Xa, serving as a broad-spectrum reversal agent for various anticoagulants, including low molecular weight heparins, unfractionated heparins, and certain direct oral anticoagulants, excluding vitamin K antagonists (VKAs). Its primary mechanism targets the coagulation pathway, facilitating the restoration of normal hemostasis in clinical situations where anticoagulation reversal is necessary. Ciraparantag acetate is valuable in research applications focused on anticoagulation management and hemostatic balance in cardiovascular studies.

Cat. No.

A74710

CAS No.

365462-23-3

Darexaban

Synonyms: YM150

Darexaban is a potent, selective, orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. It exhibits high selectivity for FXa over related serine proteases, including trypsin, thrombin, and kallikrein. Due to its anticoagulant and antithrombotic properties, Darexaban is valuable in research related to thrombosis, cardiovascular diseases, and coagulation pathways.