Bortezomib (Velcade)

Catalog No.: A10160

Proteasome inhibitor

Bortezomib (Velcade)

Bortezomib (Velcade) Chemical Structure

CAS NO. 179324-69-7

Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome

Availability: In stock

Package Price Qty
5 mg
$30.00
10 mg
$58.00
25 mg
$98.00
100 mg
$160.00
10mM * 1mL in DMSO
$50.00
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  • A Hayano, .et al. Cell-type-specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells, Int J Clin Oncol, 2019, 1-10
  • Hiroshi Fukamachi, .et al. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors, J Exp Clin Cancer Res, 2019, 38:127
  • Y Sato, .et al. S-like phase CDKs stabilize the Epstein-Barr virus BDLF4 protein to temporally control late gene transcription, J Virol, 2019, Jan 30. pii: JVI.01707-18 PMID: 30700607
  • Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
  • Wenhan Deng, .et al. Variable Responses of MYC Translocation Positive Lymphoma Cell Lines To Different Combinations of Novel Agents: Impact of BCL2 Family Protein Expression, Transl Oncol, 2018, Oct; 11(5): 1147-1154 PMID: 30055346
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Hokyung K. Chung, .et al. Tunable and reversible drug control of protein production via a self-excising degron, Nat Chem Biol, 2015, Sep; 11(9): 713-720. PMID: 26214256
  • S Raz, .et al. Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest, Cell Death Dis., 2014, 5(2): e1067 PMID: 24556682

Biological Activity

Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome
Targets
20S proteasome (Cell-free assay)
0.6 nM(Ki)
In vitro (25°C) DMSO 77 mg/mL (200.39 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.03 mL 130.14 mL 260.28 mL
0.5 mM 5.21 mL 26.03 mL 52.06 mL
1 mM 2.6 mL 13.01 mL 26.03 mL
5 mM 0.52 mL 2.6 mL 5.21 mL

*The above data is based on the productmolecular weight 384.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10160
Actions Inhibitor
M. Wt 384.2
Formula C19H25BN4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 179324-69-7
Synonyms MG-341, PS-341
SMILES B([[email protected]](CC(C)C)NC(=O)[[email protected]](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

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