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- Yoshitaka Sato, .et al. Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infection, Cell Commun Signal, 2022, Jun 21;20(1):95 PMID: 35729616
- Shin-Ichi Makino, .et al. Impairment of Proteasome Function in Podocytes Leads to CKD, J Am Soc Nephrol, 2021, Mar;32(3):597-613 PMID: 33510039
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Biological Activity
Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome
Targets
| 20S proteasome (Cell-free assay) | ||||
| 0.6 nM(Ki) |
| In vitro (25°C) | DMSO | 66 mg/mL (171.77 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.03 mL | 130.14 mL | 260.28 mL |
| 0.5 mM | 5.21 mL | 26.03 mL | 52.06 mL |
| 1 mM | 2.6 mL | 13.01 mL | 26.03 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.21 mL |
*The above data is based on the productmolecular weight 384.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10160 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 179324-69-7 |
| Formula | C19H25BN4O4 |
| M. Wt | 384.2 |
| Purity | >98% |
| Synonyms | MG-341, PS-341 |
| SMILES | B([[email protected]](CC(C)C)NC(=O)[[email protected]](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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