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Bortezomib (Velcade)

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Proteasome inhibitor

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Catalog No. A10160

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Bortezomib 5mg A10160-5

Regular Price: $30.00

Special Price: $27.00

Bortezomib 10mg A10160-10

Regular Price: $58.00

Special Price: $52.20

Bortezomib 25mg A10160-25

Regular Price: $98.00

Special Price: $88.20

Bortezomib 100mg A10160-100

Regular Price: $160.00

Special Price: $144.00

Bortezomib (Velcade) 10mM * 1mL in DMSO A10160-10mM-D

Regular Price: $50.00

Special Price: $45.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome

Bortezomib (Velcade)

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Publications citing Adooq Products
Bortezomib (Velcade) Citations (6)
  • Takashi Azuma,et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
  • Wenhan Deng,et al. Variable Responses of MYC Translocation Positive Lymphoma Cell Lines To Different Combinations of Novel Agents: Impact of BCL2 Family Protein Expression, Transl Oncol, 2018, Oct; 11(5): 1147-1154 30055346
  • Hirosumi Tamura,et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 29917168
  • Fujita KI,et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 28479358
  • Hokyung K. Chung,et al. Tunable and reversible drug control of protein production via a self-excising degron, Nat Chem Biol, 2015, Sep; 11(9): 713-720. 26214256
  • S Raz,et al. Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest, Cell Death Dis., 2014, 5(2): e1067 24556682

Chemical Information

Catalog Num A10160
Actions Inhibitor
M. Wt 384.2
Formula C19H25BN4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 179324-69-7
Synonyms MG-341, PS-341
SMILES code B([[email protected]](CC(C)C)NC(=O)[[email protected]](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
Chemical Name [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid

Biological Activity

Description
Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome
Targets
20S proteasome (Cell-free assay)
0.6 nM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 77 mg/mL (200.39 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.03 mL 130.14 mL 260.28mL
0.5 mM 5.21 mL 26.03 mL 52.06 mL
1 mM 2.6 mL 13.01 mL 26.03 mL
5 mM 0.52 mL 2.6 mL 5.21 mL

*The above data is based on the productmolecular weight 384.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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