Serine Protease

Cat. No.

A10617

CAS No.

82956-11-4

Nafamostat mesylate

Synonyms: Futhan; FUT-175

Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.

Cat. No.

A11901

CAS No.

329-98-6

PMSF

Synonyms: Benzylsulfonyl fluoride

PMSF is an irreversible serine/cysteine protease inhibitor.

Cat. No.

A12779

CAS No.

848141-11-7

Alvelestat

Synonyms: AZD9668

Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE).

Cat. No.

A14073

CAS No.

150374-95-1

Sivelestat sodium salt

Synonyms: ONO-5046

Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro.

Cat. No.

A14263

CAS No.

9087-70-1

Aprotinin

Synonyms: BPTI ,Bovine Pancreatic Trypsin Inhibitor

Aprotinin is a small protein serine protease inhibitor, used to reduce perioperative blood loss and transfusion.

Cat. No.

A14270

CAS No.

30827-99-7

AEBSF HCl

AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.

Cat. No.

A11325

CAS No.

217099-44-0

BCX 1470 methanesulfonate

Synonyms: BCX 1470

BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro.

Cat. No.

A11331

CAS No.

217099-43-9

BCX 1470

Synonyms: Thrombin inhibitor

BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro.

Cat. No.

A11764

CAS No.

59721-29-8

Camostat mesylate

Camostat mesylate is an orally active protease inhibitor. Known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin.

Cat. No.

A11825

CAS No.

611-75-6

Bromhexine hydrochloride

Bromhexine hydrochloride is a selective inhibitor of the TMPRSS2 protease, exhibiting an IC50 of 0.75 μM. This compound has demonstrated efficacy in preventing and managing SARS-CoV-2 infections. Additionally, bromhexine hydrochloride acts as an autophagy agonist and serves as a mucolytic cough suppressant, making it suitable for research related to various respiratory conditions.

Cat. No.

A13605

CAS No.

184901-82-4

AAF-CMK TFA

Synonyms: Tripeptidyl Peptidase Inhibitor II N-Ala-Ala-Phe-CMK

AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions1, and reversibly inhibits Cln2 (TPPI).

Cat. No.

A14145

CAS No.

103476-89-7

Leupeptin hemisulfate

Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain.

Cat. No.

A14184

CAS No.

127373-66-4

Sivelestat

Synonyms: Elastase Inhibitor IV

Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).

Cat. No.

A15315

CAS No.

344930-95-6

SSR 69071

SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM).

Cat. No.

A15379

CAS No.

116355-83-0

Fumonisin B1

Synonyms: Macrofusine; Macrofusin

Fumonisin B1 is a fungal metabolite produced by Fusarium moniliforme, that has been shown to inhibit protein serine/threonine phosphatases (PP1, PP2A, PP2B, PP2C, and PP5/T/K/H), and is most effective with PP5.

Cat. No.

A15705

CAS No.

6468-55-9

Demethylwedelolactone

Demethylwedelolactone is a naturally occurring coumestan that serves as a potent trypsin inhibitor with an IC50 of 3.0 μM. This compound effectively suppresses cell motility and invasion in breast cancer cells, making it a valuable tool for studying mechanisms of cancer progression and metastasis. Its functional properties may also support research into therapeutic approaches targeting proteolytic enzymes in cancer biology.

Cat. No.

A16046

CAS No.

673202-67-0

Hexa-D-arginine

Synonyms: Hexa-D-arginine aMide

Hexa-D-arginine is a inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 uM for furin, PACE4 and PC1 respectively).

Cat. No.

A16137

CAS No.

201677-61-4

Sivelestat sodium hydrate (ONO-5046 sodium hydrate)

Synonyms: ONO5046-Na; EI546 sodium; LY544349 sodium

Sivelestat sodium is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.

Cat. No.

A17158

CAS No.

1312782-34-5

AA26-9

AA26-9 is a potent and broad-spectrum serine hydrolase inhibitor.

Cat. No.

A18529

CAS No.

1803271-50-2

FXIa-IN-1

FXIa-IN-1 (compound EP-7041) is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor.

Cat. No.

A18680

CAS No.

2271122-53-1

ZK824859

ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.

Cat. No.

A18715

CAS No.

1430114-34-3

BMS-962212

BMS-962212 is a reversible, direct, and highly selective inhibitor of FXIa.

Cat. No.

A19540

CAS No.

4272-74-6

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride

N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.

Cat. No.

A20151

CAS No.

1629166-02-4

SBC-110736

SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1, Figure 1.

Cat. No.

A20516

CAS No.

220355-63-5

UKI-1

Synonyms: UKI-1C

UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator system.