E3 Ligase Ligands: Cereblon (CRBN) & VHL

Cat. No.: A80701

CAS No.: 835616-62-1

Thalidomide-5-Cl

Thalidomide-5-Cl is a thalidomide analog that serves as a useful tool in research targeting protein degradation via the PROTAC (proteolysis-targeting chimera) mechanism. It exhibits biological activity through its interaction with cereblon, leading to the recruitment of E3 ligases and subsequent ubiquitination of target proteins. This compound is valuable for studies aimed at understanding the modulation of cellular processes and the development of innovative therapeutic strategies.

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Cat. No.: A80878

CAS No.: 1950635-17-2

Thalidomide-5-(C6-amine)

Thalidomide-5-(C6-amine) is a thalidomide analogue functioning as a PROTAC building block, featuring an E3 ligase ligand with a terminal amine group. This amine group facilitates conjugation reactions with NHS ester groups or carboxylic acids in the presence of coupling agents such as EDC or HATU. Thalidomide-5-(C6-amine) is valuable in the development of bifunctional degraders, supporting research in targeted protein degradation and therapeutic interventions.

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Cat. No.: A81247

CAS No.: 2803460-96-8

5-Hydrazinyl thalidomide hydrochloride

5-Hydrazinyl thalidomide hydrochloride is a thalidomide analog that incorporates a hydrazine moiety, facilitating the development of PROTACs that target E3 ligases for the ubiquitination of specific proteins. This compound serves as a versatile intermediate, offering potential for further derivatization through reactions with a variety of carbonyl groups. Its application in chemical biology research holds promise for advancing therapeutic strategies targeting protein degradation pathways.

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25 mg

$40.00

50 mg

$60.00

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