Ligand for Target Protein for PROTAC

Cat. No.

A81280

CAS No.

2448414-41-1

PROTAC BRD9-binding moiety 1 hydrochloride

PROTAC BRD9-binding moiety 1 hydrochloride is a ligand that selectively binds to the bromodomain protein BRD9, facilitating its targeted degradation through the PROTAC (Proteolysis Targeting Chimeras) mechanism. This compound is instrumental in research focusing on protein degradation pathways and the modulation of BRD9-associated functions in various biological contexts, such as cancer and inflammation. It serves as a valuable tool for studying the therapeutic potential of targeting BRD9 in disease models.

Cat. No.

A81282

CAS No.

2460248-49-9

BRD9 ligand-6

BRD9 ligand-6 serves as a ligand for the BRD9 target protein, facilitating the development of PROTAC (Proteolysis Targeting Chimeras) compounds. This reagent exhibits specific binding properties that enable the selective degradation of target proteins in cellular models. It is particularly valuable in research applications focused on targeted protein degradation and therapeutic intervention strategies.

Cat. No.

A81283

CAS No.

1936431-36-5

Piperidine-GNE-049-N-Boc

Piperidine-GNE-049-N-Boc is a ligand that targets the dCBP-1 protein, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound serves as a potent and selective heterobifunctional degrader for the transcriptional co-activators p300 and CBP. It is applicable in research aimed at understanding protein degradation mechanisms and the modulation of gene expression.

Cat. No.

A81284

CAS No.

2375354-13-3

Demethyl-RSL3

Demethyl-RSL3 functions as a ligand for targeted protein degradation through the proteolysis targeting chimera (PROTAC) mechanism. This compound effectively modulates cellular pathways by inducing degradation of specific proteins. Its applications lie primarily in cancer research and the development of novel therapeutic strategies aimed at improving targeted protein degradation efficacy.

Cat. No.

A81285

CAS No.

1603845-36-8

PROTAC Her3-binding moiety 1

PROTAC Her3-binding moiety 1 is a ligand designed to selectively target the HER3 protein, facilitating its degradation via the PROTAC (PROteolysis TArgeting Chimeras) technology. This compound plays a critical role in modulating HER3 activity, which is implicated in various cancer pathways. Its application in research includes studying HER3 signaling and developing targeted therapies for HER3-expressing malignancies.

Cat. No.

A81288

CAS No.

3031327-95-1

PROTAC CDK9 ligand-1

PROTAC CDK9 ligand-1 is a potent ligand for cyclin-dependent kinase 9 (CDK9), facilitating the synthesis of PROTAC (proteolysis-targeting chimera) constructs. This compound is instrumental for targeted protein degradation studies, enabling researchers to modulate CDK9 activity and investigate its role in transcription regulation and cancer biology. PROTAC CDK9 ligand-1 supports the development of innovative therapeutic strategies aimed at selectively degrading unwanted or malfunctioning proteins.

Cat. No.

A81289

CAS No.

1616391-79-7

PRMT5 ligand 2

PRMT5 ligand 2 is a selective ligand targeting protein arginine methyltransferase 5 (PRMT5) for use in PROTAC (proteolysis-targeting chimeras) applications. This compound facilitates the targeted degradation of PRMT5, enabling researchers to investigate its role in various cellular processes, including gene regulation and cell signaling. PRMT5 ligand 2 serves as an essential tool for studying PRMT5's biological functions and elucidating potential therapeutic targets in cancer and other diseases.

Cat. No.

A81291

CAS No.

2447066-00-2

BMS-1166-N-piperidine-COOH

BMS-1166-N-piperidine-COOH is a ligand designed to target E3 ligase for PROTAC applications. This compound serves as a key component in the synthesis of PD-1/PD-L1 degrader-1, which facilitates the degradation of the PD-1/PD-L1 complex, a crucial immune checkpoint. With a potent PD-1/PD-L1 interaction inhibition demonstrated by an IC50 of 1.4 nM, BMS-1166-N-piperidine-COOH effectively reverses the suppressive effects of the PD-1/PD-L1 pathway on T cell activation, making it valuable for cancer immunotherapy research.

Cat. No.

A81292

CAS No.

3038591-92-0

PIN1 ligand-1

PIN1 ligand-1 serves as a ligand for the target protein in PROTAC (Proteolysis Targeting Chimera) applications. This compound plays a crucial role in the design and synthesis of PROTACs that can mediate the selective degradation of PIN1, thereby facilitating targeted approaches in cancer research and other therapeutic areas. Its specific interaction with PIN1 makes it an essential tool for studying protein degradation pathways and developing novel therapeutic strategies.

Cat. No.

A81293

CAS No.

3057446-77-9

MJBIA9836

MJBIA9836 is a protein ligand designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. It facilitates targeted degradation of specific proteins, enabling researchers to study protein function and regulation in various biological contexts. MJBIA9836 serves as a valuable tool in drug discovery and therapeutic research, particularly in exploring targeted protein degradation strategies.

Cat. No.

A81294

CAS No.

2408341-98-8

PROTAC PTK6 ligand-1

PROTAC PTK6 ligand-1 is a small molecule ligand targeting protein kinases for use in PROTAC (Proteolysis Targeting Chimera) applications. It functions as an intermediate in the synthesis of BTK (Bruton’s tyrosine kinase) inhibitors, facilitating targeted degradation of specific proteins. This compound is important for researching targeted therapeutic strategies in oncology and autoimmune diseases, especially in relation to kinase signaling pathways.

Cat. No.

A81296

CAS No.

2357108-39-3

PROTAC IRAK4 ligand-1

PROTAC IRAK4 ligand-1 is a synthetic ligand specifically designed to target interleukin-1 receptor-associated kinase 4 (IRAK4). This compound plays a critical role in the development of PROTAC IRAK4 degrader-1, facilitating targeted protein degradation. Its primary applications include cancer research and studies investigating inflammatory pathways, making it a valuable tool for researchers exploring IRAK4-related signaling mechanisms.

Cat. No.

A81297

CAS No.

2351218-72-7

A-1210477-piperazinyl

Synonyms: PROTAC Mcl1-binding moiety 1

A-1210477-piperazinyl is a ligand that specifically binds to myeloid cell leukemia 1 (MCL1), serving as a crucial component in PROTAC (proteolysis-targeting chimeras) technology. This compound plays a significant role in targeted protein degradation research, enabling the modulation of MCL1 levels in various cellular contexts. A-1210477-piperazinyl is valuable for studies aimed at understanding MCL1's involvement in cell survival and cancer biology.

Cat. No.

A81298

CAS No.

1001264-73-8

Ipatasertib-NH2 dihydrochloride

Synonyms: GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride

Ipatasertib-NH2 dihydrochloride serves as a ligand for the target protein AKT, functioning within the PROTAC (INY-03-041) platform. This compound includes Ipatasertib-NH2 linked through a ten-carbon linker to a CRBN ligand, Lenalidomide, facilitating interactions with the E3 ubiquitin ligase. It is a valuable tool for investigating the degradation of AKT and exploring therapeutic avenues in cancer and other diseases characterized by dysregulated AKT signaling.

Cat. No.

A81301

CAS No.

3039841-82-9

PCSK9 ligand 2

PCSK9 ligand 2 functions as a target protein ligand for PROTAC PCSK9 autophagic degrader 2, facilitating the selective degradation of PCSK9. This compound plays a vital role in lowering cholesterol levels by enhancing the clearance of LDL receptors, making it useful in anti-atherosclerosis research. Its application can aid in the development of novel therapeutic strategies aimed at cardiovascular diseases associated with lipid metabolism.

Cat. No.

A81304

CAS No.

3030281-30-9

CDK2 ligand-2

CDK2 ligand-2 is a selective ligand targeting cyclin-dependent kinase 2 (CDK2), facilitating the synthesis of PROTAC (proteolysis targeting chimera) molecules. By combining CDK2 ligand-2 with E3 Ligase Ligand-linker Conjugate 184, researchers can create CDK2 degrader 2, a potent tool for targeted protein degradation studies. This compound is valuable for investigating CDK2's role in cell cycle regulation and exploring therapeutic strategies in cancer research.

Cat. No.

A81305

CAS No.

2757424-54-5

AR antagonist 14

AR Antagonist 14 is a potent ligand for specific target proteins utilized in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the development of targeted protein degraders, allowing for the selective degradation of androgen receptors. AR Antagonist 14 can be effectively combined with VH 101-amide-piperidine-Pip-alkyne to synthesize PROTAC degraders, enhancing research on targeted therapies in cancer and other diseases.

Cat. No.

A81306

CAS No.

1373410-40-2

Naproxen Gilteritinib

Naproxen Gilteritinib is an active reference substance for Gilteritinib, serving as a ligand for target proteins. It plays a crucial role in the mechanism of action of PROTAC degrader LWY713. This compound is essential for research applications focused on targeted protein degradation and the development of novel therapeutic strategies in precision medicine.

Cat. No.

A81307

CAS No.

1065573-84-3

KAL-21404358

KAL-21404358 is a ligand designed for specific binding to target proteins for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the targeted degradation of proteins, providing valuable insights into protein function and regulation. Research applications include the study of protein-protein interactions and the development of targeted therapies in cancer and other diseases. KAL-21404358 supports the advancement of innovative approaches in drug discovery and biological research.

Cat. No.

A81308

CAS No.

3024271-84-6

SMARCA2 ligand-10

SMARCA2 ligand-10 is a specific ligand for the SMARCA2 protein, facilitating the development of targeted protein degradation techniques. This compound is utilized in the synthesis of PROTAC SMARCA2 degrader-28, enabling selective modulation of SMARCA2 activity. Its application is valuable for research into cancer biology and therapeutic strategies that involve targeted degradation of oncogenic proteins.

Cat. No.

A81311

CAS No.

3032975-34-8

PTPN2 ligand 1

PTPN2 ligand 1 is a specific ligand designed for the PTPN2 target protein, facilitating the development of PROTAC (proteolysis-targeting chimeras). This compound plays a crucial role in research applications focused on targeted protein degradation, providing researchers with the means to investigate the functional relevance of PTPN2 in various biological processes. Additionally, it serves as a synthetic precursor for the compound PVD-06, contributing to further studies in protein modulation.

Cat. No.

A81312

CAS No.

3058483-40-9

Demethyl-NSC682769

Demethyl-NSC682769 functions as a ligand for target proteins in PROTAC applications. It plays a critical role in the development of PROTAC YAP degrader-1, facilitating targeted degradation of YAP protein. This compound is essential for researchers exploring the mechanism of targeted protein degradation and its therapeutic potential in cancer and other diseases.

Cat. No.

A81313

CAS No.

2139329-57-8

Palbociclib-CH2COOH

Palbociclib-CH2COOH is a ligand designed for the Target Protein in PROTAC applications. This compound can function as an active control for evaluating the target protein ligand interactions of CPD-39 and CPD-10. Its specificity and binding capacity make it a valuable tool for researchers investigating targeted protein degradation and related pathways.

Cat. No.

A81318

CAS No.

2467965-59-7

PRC1 ligand 1

PRC1 ligand 1 is a target protein ligand that interacts specifically with the PRC1 protein complex. This compound is primarily utilized in cancer research, providing insights into the mechanisms of cell proliferation and differentiation. Its role in modulating PRC1 activity makes it a valuable tool for studying tumorigenesis and potential therapeutic interventions.

Cat. No.

A81320

CAS No.

2836297-58-4

CYP1B1 ligand 2

CYP1B1 ligand 2 is an active ligand targeting the CYP1B1 protein, playing a critical role in the mechanism of the PROTAC CYP1B1 degrader-2. This compound is utilized in research to explore its biological activity related to lung cancer, providing insights into potential therapeutic applications and the underlying mechanisms of tumorigenesis.