Ligand for Target Protein for PROTAC

Cat. No.

A54281

CAS No.

2408642-48-6

FN-1501-propionic acid

FN-1501-propionic acid is a ligand targeting cyclin-dependent kinases 2 and 9 (CDK2/9), utilized in the development of PROTAC (proteolysis targeting chimeras) for targeted protein degradation. This compound can be combined with a CRBN ligand to facilitate the design of PROTAC-based CDK2/9 degraders, enabling selective degradation of these kinases. Its application in research enhances the study of cellular processes regulated by CDK2 and CDK9, making it a valuable tool for investigating therapeutic strategies against diseases associated with dysregulated kinase activity.

Cat. No.

A54295

CAS No.

1211585-07-7

CDK2/4 ligand 1

CDK2/4 Ligand 1 is a specific ligand targeting cyclin-dependent kinases CDK2 and CDK4, designed for use in the development of proteolysis-targeting chimeras (PROTACs). It facilitates the synthesis of PROTAC CDK2/4 Degrader-1, enabling targeted degradation of these kinases to explore their role in various biological processes and cancers. This compound is essential for research applications focused on targeted protein degradation mechanisms.

Cat. No.

A56888

CAS No.

755039-56-6

dTAG Targeting Ligand 1

dTAG Targeting Ligand 1 is a ligand specifically designed for the targeted degradation of proteins using PROTAC technology. This compound facilitates the selective recruitment of E3 ligases to the target protein, promoting its ubiquitination and subsequent proteasomal degradation. dTAG Targeting Ligand 1 serves as a crucial tool in studies aimed at exploring protein function, validating drug targets, and developing novel therapeutic strategies through protein degradation.

Cat. No.

A57048

CAS No.

2380272-56-8

SMARCA-BD ligand 1 for PROTAC hydrochloride

SMARCA-BD ligand 1 for PROTAC hydrochloride is a selective ligand that specifically targets the BAF ATPase subunit SMARCA2. This compound facilitates the degradation of SMARCA2 through the PROTAC mechanism, making it a valuable tool for research into protein degradation pathways and epigenetic regulation. Its applications extend to studies on cancer biology and the development of targeted therapeutic strategies.

Cat. No.

A57052

CAS No.

2369053-68-7

SMARCA-BD ligand 1 for PROTAC dihydrochloride

SMARCA-BD ligand 1 for PROTAC dihydrochloride is a selective ligand targeting the BAF ATPase subunit SMARCA2. This compound facilitates the proteolytic degradation of SMARCA2 through the PROTAC mechanism, thereby modulating its biological activity. It is utilized in research applications focused on the regulation of chromatin remodeling and exploring therapeutic avenues for diseases associated with altered SMARCA2 function.

Cat. No.

A57053

CAS No.

1997320-33-8

SMARCA2 ligand-9

SMARCA2 ligand-9 is a selective ligand for the target protein SMARCA2, designed for use in proteolysis-targeting chimera (PROTAC) applications. This compound facilitates the synthesis of PROTAC SMARCA2 degrader-27, enabling targeted degradation of SMARCA2 in cellular studies. Researchers can utilize SMARCA2 ligand-9 to investigate the role of SMARCA2 in various biological processes and assess its potential as a therapeutic target in cancer research and other diseases.

Cat. No.

A57054

CAS No.

2660235-29-8

SMARCA2 ligand-13

SMARCA2 ligand-13 is a targeted ligand designed for use in PROTAC (Proteolysis Targeting Chimera) applications, specifically interacting with the SMARCA2 protein. This compound facilitates the synthesis of PROTACs, enabling the targeted degradation of proteins associated with various diseases. Its primary utilization lies in the advancement of therapeutic strategies that leverage the ubiquitin-proteasome system for selective protein modulation in chemical biology research.

Cat. No.

A57056

CAS No.

3033592-44-5

SMARCA2 ligand-11

SMARCA2 ligand-11 is a specific ligand for the chromatin remodeling factor SMARCA2, facilitating the development of PROTACs such as SMARCA2 degrader-32. This compound is instrumental in research applications focused on targeted protein degradation, particularly in studies aimed at elucidating the role of SMARCA2 in various biological processes and diseases. Its ability to selectively engage with SMARCA2 allows for investigations into novel therapeutic strategies in cancer and other conditions where SMARCA2 activity is implicated.

Cat. No.

A57964

CAS No.

3056514-89-4

Androgen receptor ligand 2

Androgen Receptor Ligand 2 acts as a ligand for the androgen receptor, facilitating the targeted degradation of this protein through the PROTAC (proteolysis-targeting chimera) mechanism. This compound is integral for the synthesis of the PROTAC Androgen Receptor Degrader-1, enabling researchers to probe the functional role of the androgen receptor in various biological contexts. Its application extends to studies in cancer research and hormone-related disorders, where modulation of androgen receptor activity may serve as a therapeutic strategy.

Cat. No.

A65578

CAS No.

2762552-73-6

STING ligand-3

STING ligand-3 functions as a ligand for the target protein, enabling the control of PROTAC activity. This compound plays a critical role in the synthesis of anti-inflammatory agents, specifically Anti-inflammatory agent 70. Its application in chemical research can facilitate advancements in understanding inflammatory pathways and developing therapeutic strategies.

Cat. No.

A65824

CAS No.

212631-56-6

MEK ligand-2

MEK ligand-2 is a ligand specifically designed for PROTAC applications targeting MEK1 and MEK2 proteins. This compound serves as a vital component for the development of the MS934 PROTAC, facilitating the degradation of MEK1 and MEK2 via a VHL-recruiting mechanism. It plays a crucial role in research aimed at understanding the regulation of MAPK signaling pathways and potential therapeutic strategies in cancer biology.

Cat. No.

A65864

CAS No.

3027977-34-7

PROTAC SOS1 ligand 1

PROTAC SOS1 ligand 1 is a high-affinity ligand for the SOS1 protein, facilitating targeted protein degradation through PROTAC technology. This compound is instrumental in the development of therapeutic strategies by enabling the selective modulation of SOS1, which plays a pivotal role in various oncogenic signaling pathways. Researchers can utilize this reagent in studies focused on cancer biology and drug discovery, particularly in exploring novel approaches to target and degrade specific proteins associated with tumor progression.

Cat. No.

A75757

CAS No.

3048196-74-0

IDO1 ligand-1

IDO1 ligand-1 is a specific ligand that interacts with the IDO1 protein, facilitating targeted protein degradation through the PROTAC mechanism. This compound is instrumental in research focused on IDO1 modulation, which has implications in oncology and immunology. By effectively promoting the degradation of IDO1, IDO1 ligand-1 serves as a valuable tool for investigating the therapeutic potential of PROTACs in various biological contexts.

Cat. No.

A79473

CAS No.

2052306-12-2

TBK1 ligand 2-C-O-C4-O-C3-O-C-amide

TBK1 ligand 2-C-O-C4-O-C3-O-C-amide is a protein ligand-linker conjugate specifically designed to facilitate the development of targeted protein degraders. This compound serves as a crucial component in the synthesis of the PROTAC TBK1 degrader-2, enabling selective degradation of the TBK1 protein. Its application in chemical biology research allows for the investigation of TBK1's role in various cellular processes and the potential modulation of its activity.

Cat. No.

A79524

CAS No.

3082764-64-2

Nrf2 activator-22

Nrf2 activator-22 is a ligand specifically targeting the Nrf2 protein, playing a crucial role in the development of PROTAC-based therapeutics. This compound facilitates the synthesis of PROTAC K-Ras Degrader-7, highlighting its potential in targeted protein degradation research. Nrf2 activator-22 is valuable for studies aimed at manipulating oxidative stress responses and related signaling pathways.

Cat. No.

A79856

CAS No.

2769753-45-7

PI3Kγ ligand 1

PI3Kγ ligand 1 is a selective ligand for phosphoinositide 3-kinase gamma (PI3Kγ), utilized in the development of proteolysis-targeting chimeras (PROTACs). This compound effectively engages with PI3Kγ, facilitating targeted protein degradation. Its biological activity makes it valuable for research applications in cancer therapeutics and immunology, particularly in elucidating PI3K signaling pathways.

Cat. No.

A81258

CAS No.

2154342-61-5

Thalidomide-5-piperazine

Thalidomide-5-piperazine is a ligand designed for protein-targeted degradation utilizing the PROTAC technology. This compound facilitates the recruitment of E3 ubiquitin ligases to specific target proteins, promoting their ubiquitination and subsequent proteasomal degradation. It is primarily used in research applications focused on studying protein function and modulation within cellular pathways.

Cat. No.

A81267

CAS No.

2484741-78-6

CBP/p300 ligand 2

CBP/p300 ligand 2 is a selective ligand targeting the dCBP-1 protein, facilitating its role as a heterobifunctional degrader of the p300/CBP proteins. This compound is essential for research applications focused on targeted protein degradation, enabling the study of p300/CBP's involvement in various biological processes and diseases. Its utility in PROTAC development makes it a valuable tool for investigating therapeutic strategies in cancer and other disorders linked to aberrant p300/CBP activity.

Cat. No.

A81269

CAS No.

2467965-71-3

EED226-COOH

EED226-COOH is an EED226-derived ligand that targets the EED protein, facilitating the formation of PROTACs. This compound effectively binds to a VHL ligand through a linker, leading to the degradation of the PRC2 complex. EED226-COOH is valuable for research applications focused on targeted protein degradation and studying the roles of PRC2 in various biological processes.

Cat. No.

A81270

CAS No.

1001382-14-4

Ipatasertib-NH2

Synonyms: GDC-0068-NH2; RG7440-NH2

Ipatasertib-NH2 is a targeted ligand for the protein AKT, functioning as a key component in PROTAC-mediated degradation systems, specifically in INY-03-041. This compound is structured with a ten-hydrocarbon linker and the CRBN ligand Lenalidomide, enabling selective recruitment of E3 ubiquitin ligase for targeted protein degradation. Its utility in research includes elucidating AKT's role in cellular signaling and developing novel therapeutic strategies.

Cat. No.

A81271

CAS No.

2769753-10-6

TAE648

TAE648 is a ligand specifically designed for target proteins involved in PROTAC (Proteolysis Targeting Chimeras) research. This compound plays a crucial role in the synthesis of PROTAC SK-3-91, facilitating targeted degradation of specific proteins. Its applications span various areas of chemical biology and drug discovery, advancing studies in protein modulation and therapeutic development.

Cat. No.

A81274

CAS No.

2366269-23-8

Palbociclib-propargyl

Synonyms: PROTAC CDK6 ligand 1

Palbociclib-propargyl is a selective ligand for CDK6, designed for use in PROTAC applications. This compound functions through a PEG linker to effectively bind to the CRBN ligand, forming the PROTAC CP-10, which exhibits a DC50 of 2.1 nM for CDK6. Additionally, Palbociclib-propargyl features an alkyne group making it suitable for click chemistry, specifically allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules. This reagent is valuable for advancing research in targeted protein degradation and cancer therapeutics.

Cat. No.

A81275

CAS No.

2955618-24-1

(S)-SKBG-1

(S)-SKBG-1 is a covalent ligand designed for targeting specific proteins in the context of PROTAC applications. Though classified as inactive, it serves an essential role as an assay control to help validate experimental conditions and results. This compound is valuable for researchers investigating the mechanisms of protein degradation and the development of targeted therapeutic strategies.

Cat. No.

A81276

CAS No.

2685873-44-1

Tazemetostat de(methyl morpholine)-COOH

Tazemetostat de(methyl morpholine)-COOH is a ligand specifically designed for the target protein EZH2, facilitating the synthesis of EZH2 degraders for the PROTAC approach. This compound exhibits significant biological activity by effectively inhibiting cell viability in diffuse large B-cell lymphoma (DLBCL) and various lymphoma subtypes. It serves as a valuable tool for researchers investigating targeted protein degradation and its therapeutic potential in oncology.

Cat. No.

A81277

CAS No.

1339378-93-6

SMARCA2/4-IN-2

SMARCA2/4-IN-2 is a ligand specifically designed for the SMARCA2 and SMARCA4 proteins, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical component in the synthesis of PROTAC SMARCA2/4-degrader-5, enabling targeted degradation of these chromatin remodelers. SMARCA2/4-IN-2 is valuable for research applications in cancer biology and therapeutic development focused on modulation of epigenetic regulators.