Hedgehog

Cat. No.

A44260

CAS No.

57651-82-8

3-epi-Vitamin D3

Synonyms: Epicholecalciferol

3-epi-Vitamin D3, also known as Epicholecalciferol, functions as a Hedgehog pathway inhibitor, exhibiting an IC50 value of 39.2 μM in U87MG cell lines. This Vitamin D3 analogue is useful in studies investigating the modulation of the Hedgehog signaling pathway, which plays a critical role in cellular growth and differentiation. 3-epi-Vitamin D3 may have potential applications in cancer research, particularly in contexts where Hedgehog dysregulation is implicated.

Cat. No.

A44261

CAS No.

330796-24-2

Hedgehog IN-1

Hedgehog IN-1 is a potent inhibitor of the Hedgehog signaling pathway, demonstrating an IC50 of 70 nM. This compound effectively blocks Hedgehog protein activity, making it valuable for research into developmental biology and cancer therapeutics. Hedgehog IN-1 is instrumental in studies aimed at understanding the role of the Hedgehog pathway in tumorigenesis and potential therapeutic applications in related disorders.

Cat. No.

A44266

CAS No.

1126366-36-6

AZD8542

AZD8542 is a potent Smoothened (SMO) antagonist that effectively disrupts the Hedgehog (Hh) signaling pathway, which is crucial in tumor progression. This compound is particularly relevant in oncology research, focusing on the interactions within the tumor microenvironment and the stroma compartment. AZD8542's ability to inhibit Hh pathway activity makes it a valuable tool in the study of cancer therapies and tumor biology.

Cat. No.

A44267

CAS No.

2130846-15-8

HL2-m5

HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, exhibiting a Kd of 170 nM for Shh. This compound effectively disrupts the activation of the Hedgehog signaling pathway and inhibits the transcription of Gli-controlled genes, with an IC50 of 230 nM. HL2-m5 serves as a valuable tool for research focused on developmental biology, cancer biology, and the modulation of signaling pathways associated with abnormal cellular growth.

Cat. No.

A44270

CAS No.

1186293-14-0

Smo antagonist M25

Smo antagonist M25 is a selective inhibitor of the Smoothened (Smo) receptor within the Hedgehog signaling pathway. By blocking Smo activity, it effectively attenuates the downstream effects of Hedgehog signaling, which plays a crucial role in cell proliferation and differentiation. This compound is primarily utilized in research applications focusing on cancer biology, developmental processes, and potential therapeutic interventions associated with aberrant Hedgehog pathway activation.

Cat. No.

A44271

CAS No.

1126365-74-9

Hedgehog IN-2

Hedgehog IN-2 is a potent inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 value of less than 0.003 μM in C3H10T1/2 cells. This compound effectively disrupts Hedgehog-mediated cellular signaling, making it a valuable tool for studying embryonic development, cancer biology, and regenerative medicine. Its high potency and specificity enable researchers to investigate the role of the Hedgehog pathway in various biological processes and disease states.

Cat. No.

A44272

CAS No.

3091880-01-9

2-ACC

Synonyms: 2-α-Carboxy cholestanol

2-ACC (2-α-Carboxy cholestanol) is identified as a D46A activator of the Sonic Hedgehog protein, exhibiting an EC50 of approximately 5 μM. This compound is essential for studies involving hedgehog signaling pathways and can be utilized in research focused on developmental biology and cancer therapeutics. Its activation of the D46A mutant provides valuable insights into protein interactions and cellular responses mediated by the Sonic Hedgehog pathway.

Cat. No.

A44275

CAS No.

2916444-33-0

Hedgehog IN-6

Hedgehog IN-6 is a potent Hedgehog (Hh) inhibitor that targets the Hh signaling pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo). By obstructing the cholesterization of Smo, Hedgehog IN-6 effectively inhibits Hh pathway activation, which is crucial in various cancer types. This compound is valuable for research applications aimed at understanding and manipulating Hh signaling in oncogenesis and developmental biology.

Cat. No.

A44276

CAS No.

3093738-79-2

HPP-9

HPP-9 is a Hedgehog Pathway inhibitor designed as a Proteolysis-Targeting Chimera (PROTAC) that effectively degrades BET bromodomains. With a pIC50 of 6.71, HPP-9 exhibits significant antitumor activity. This compound is valuable for research applications focused on cancer biology and the modulation of the Hedgehog signaling pathway.

Cat. No.

A44277

CAS No.

1128191-09-2

Hedgehog IN-3

Hedgehog IN-3 is a potent inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of 0.01 µM. This compound is primarily utilized in cancer research to investigate the role of Hedgehog-mediated signaling in tumorigenesis and cellular proliferation. Its effectiveness in modulating this pathway makes it a valuable tool for studying various malignancies and developing targeted therapeutic strategies.

Cat. No.

A44278

CAS No.

1057677-92-5

Hedgehog IN-10

Hedgehog IN-10 is a potent inhibitor of the Hedgehog signaling pathway, targeting essential components in cellular signaling. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. Its ability to modulate Hedgehog signaling contributes to investigations into therapeutic strategies for tumors associated with dysregulated Hedgehog pathway activity.

Cat. No.

A44281

CAS No.

1544681-93-7

Hedgehog IN-5

Hedgehog IN-5 is a small molecule inhibitor that targets the Hedgehog signaling pathway. This orally active compound is primarily employed in research pertaining to fibrotic diseases, providing valuable insights into the mechanisms underlying this condition. Its ability to modulate Hedgehog pathway activity makes it a significant tool for exploring therapeutic strategies in related biological contexts.

Cat. No.

A44283

CAS No.

496793-78-3

Methoxy-SANT-2

Synonyms: TC-132

Methoxy-SANT-2 is a potent Hedgehog pathway antagonist, demonstrating an IC50 value of 79.8 nM. It effectively inhibits Gli1 reporter gene expression, making it a valuable tool in investigating Hedgehog signaling. This compound is suitable for research applications focused on cancer biology and therapeutic strategies targeting the Hedgehog pathway.

Cat. No.

A44284

CAS No.

1616368-12-7

Hedgehog IN-4

Hedgehog IN-4 is a potent inhibitor of the Hedgehog signaling pathway, acting as a benzamide derivative with an IC50 of 0.050 nM. It effectively disrupts Hedgehog-mediated cellular processes, making it valuable for research on developmental biology, cancer, and regenerative medicine. Its ability to modulate this critical pathway allows for exploration into the mechanisms of diseases associated with Hedgehog signaling dysregulation.

Cat. No.

A44289

CAS No.

1314295-24-3

BRD50837

BRD50837 is a potent inhibitor of Sonic Hedgehog (Shh) signaling, exhibiting an EC50 of 0.09 μM. This compound effectively modulates Shh activity, making it a valuable tool in cancer research. Its ability to interfere with Shh pathway signaling can be explored in studies related to tumorigenesis and developmental processes.