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GLP-1 Receptors

GLP-1 receptor agonists and modulators act on the receptor for glucagon-like peptide 1 (GLP-1), an incretin hormone. Intestinal L cells release GLP-1 after a meal, and the hormone enhances glucose-dependent insulin secretion from pancreatic beta cells. The receptor, a class B G protein-coupled receptor, was cloned from beta cells by expression cloning in 1992. Peptide agonists in this category include liraglutide and lixisenatide, while tirzepatide also acts at the glucose-dependent insulinotropic polypeptide (GIP) receptor. BETP is a small-molecule ligand that binds the GLP-1 receptor outside the peptide site. The set also includes dipeptidyl peptidase 4 (DPP-4) inhibitors such as linagliptin, which slow the breakdown of endogenous GLP-1.

1 Item

  • GLP-2(3-33)
    Cat. No.
    A60461
    CAS No.
    275801-62-2

    GLP-2(3-33)

    GLP-2(3-33) is a partial agonist of the GLP-2 receptor, generated through the enzymatic action of dipeptidylpeptidase IV (DPPIV). It exhibits biological activity with an EC50 of 5.8 nM, making it a valuable tool for research into gastrointestinal physiology and potential therapeutic applications in metabolic disorders. Its role in modulating the GLP-2 receptor provides insight into gut hormone signaling and its effects on intestinal growth and function.

    In stock View Details
    1 mg
    $225.00
    5 mg
    $695.00
    All 2 sizes

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