- Cat. No.
- A22008
MK-0354
MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b.
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G protein reagents here range from guanine nucleotides to ligands for orphan G protein-coupled receptors. Heterotrimeric G proteins consist of a Gα subunit, which binds guanine nucleotides, and a tightly associated Gβγ dimer. An activated G protein-coupled receptor (GPCR) exchanges guanosine diphosphate (GDP) for guanosine triphosphate (GTP) on Gα, which then separates from Gβγ. Guanosine 5'-triphosphate trisodium salt is listed as a G protein activator, but most other compounds act on less studied receptors. G15 blocks the G protein-coupled estrogen receptor (GPER, also called GPR30), and CID16020046 antagonizes G protein-coupled receptor 55 (GPR55). Kynurenic acid, an endogenous tryptophan metabolite, is listed as a GPR35 agonist. GTPase-accelerating proteins that end the signal are covered in RGS Protein.
MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b.