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Vasopressin Receptor

Vasopressin receptor antagonists and agonists target the receptors for the hormone arginine vasopressin. The V1a receptor mediates vascular contraction, the V1b receptor controls pituitary corticotropin release, and the V2 receptor regulates water reabsorption in the kidney. Cloning of the rat V1a receptor and of the V2 receptor was reported in 1992, and V2 receptor defects were linked to nephrogenic diabetes insipidus. Tolvaptan and mozavaptan are nonpeptide V2 receptor antagonists, while conivaptan hydrochloride blocks both V1a and V2 receptors. OPC21268 is a V1 antagonist, and Vasopressin antagonist 1867 targets the V1b receptor. Peptide agonists such as desmopressin and terlipressin serve as tools for receptor activation studies.

1 Item

  • Invopressin
    Cat. No.
    A64006
    CAS No.
    1488411-60-4

    Invopressin

    Synonyms: OCE-205

    Invopressin is a partial agonist of the V1A vasopressin receptor, exhibiting an EC50 of 1.0 nM. It is primarily utilized in research focused on cirrhosis-related conditions, including bacterial peritonitis, hepatorenal syndrome type 2 (HRS2), and refractory ascites. This compound enables the investigation of therapeutic strategies targeting vasopressin-mediated pathways in these clinical scenarios.

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    1 mg
    $145.00
    5 mg
    $370.00
    All 3 sizes

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