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Somatostatin Receptors

Somatostatin receptor (SSTR) agonists and antagonists act on SSTR1 to SSTR5, five G protein-coupled receptors. Somatostatin was isolated from hypothalamus in 1973 as a peptide that inhibits growth hormone secretion from the pituitary. Its receptors couple mainly to inhibitory G proteins, lower cyclic adenosine monophosphate (cAMP) and suppress hormone release in the pituitary, pancreas and gut. Human and mouse somatostatin receptors were cloned in 1992 and found in brain, gastrointestinal tract and kidney. The natural peptide is listed together with cyclic somatostatin, octreotide acetate and pasireotide L-aspartate salt, stable analogs with different subtype profiles. Subtype tools include the SSTR2 antagonist CYN-154806, the SSTR4 agonist J-2156, and SSTR5 antagonist 1 and SSTR5 antagonist 2.

3 Items

  • Angiopeptin TFA
    Cat. No.
    A23225
    CAS No.
    2478421-60-0

    Angiopeptin TFA

    Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.

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    5 mg
    $115.00
    10 mg
    $175.00
    All 3 sizes
  • Angiopeptin
    Cat. No.
    A58104
    CAS No.
    113294-82-9

    Angiopeptin

    Angiopeptin is a cyclic octapeptide analogue of somatostatin that acts as a partial agonist at the sst2 and sst5 receptors, exhibiting IC50 values of 0.26 nM and 6.92 nM, respectively. This compound effectively inhibits growth hormone secretion and reduces insulin-like growth factor-1 (IGF-1) production. Angiopeptin also modulates cellular signaling by inhibiting adenylate cyclase and stimulating extracellular acidification. Its unique properties make it a valuable tool for research into coronary atherosclerosis and related metabolic disorders.

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    Out of stock

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  • L-796778
    Cat. No.
    A63875
    CAS No.
    217480-25-6

    L-796778

    L-796778 is a partial agonist of the human SST3 receptor. It effectively inhibits forskolin-stimulated cAMP production in CHO-K1 cells expressing the SST3 receptor, with an IC50 value of 18 nM. This compound is valuable for research into signaling pathways involving the SST3 receptor, potentially aiding investigations in neuroendocrine regulation and related pharmacological applications.

    In stock View Details
    1 mg
    $155.00
    5 mg
    $365.00
    All 7 sizes

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