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Carbonic Anhydrase

Carbonic anhydrase (CA) inhibitors block zinc enzymes that interconvert carbon dioxide and bicarbonate. The enzyme was purified from red blood cells in 1933 and shown to speed up the hydration of carbon dioxide. Humans express many CA isoforms, which regulate pH, ion transport, fluid secretion and respiration. CA IX, cloned in 1994 as a tumor-associated protein, is induced by hypoxia in many solid tumors. Most inhibitors are sulfonamides that bind the active-site zinc, from the parent benzenesulfonamide to dorzolamide, brinzolamide and diclofenamide. DTP348 is a CA IX inhibitor that is also described as a radiosensitizer. Indisulam, another sulfonamide, is also studied as a molecular glue that degrades RNA-binding motif protein 39 (RBM39).

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  • Carbonic anhydrase activator 1
    Cat. No.
    A41234
    CAS No.
    2374923-30-3

    Carbonic anhydrase activator 1

    Carbonic Anhydrase Activator 1 is a potent activator of carbonic anhydrase (CA) enzymes, selectively targeting human CA I, CA VA, and CA VII with KAs of 7.8, 3.9, and 2.1 μM, respectively. This compound is orally bioavailable and effectively crosses the blood-brain barrier, making it a valuable tool in studies of diseases such as cancer, glaucoma, cardiovascular disorders, and neurodegenerative conditions like epilepsy. Its pharmacological properties support its application in investigating therapeutic strategies and mechanisms related to these pathological states.

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