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LXR

Liver X receptor (LXR) agonists and antagonists act on oxysterol-activated nuclear receptors. LXRα and LXRβ were shown in 1996 to respond to oxidized cholesterol derivatives such as 24,25-epoxycholesterol. Through sterol regulatory element-binding protein 1c (SREBP-1c) they link sterol sensing to fatty acid synthesis in liver, and they also drive genes of reverse cholesterol transport. GW3965 and GW3965 HCl are synthetic agonists of both subtypes and are widely used in such gene expression work. T0901317 activates LXR but also acts on the farnesoid X receptor, so selectivity controls matter. GSK-2033 acts as an antagonist and SR9243 as an inverse agonist, which allows loss-of-function comparisons in the same system.

4 Items

  • Taraxasterol
    Cat. No.
    A35789
    CAS No.
    1059-14-9

    Taraxasterol

    Taraxasterol is a pentacyclic triterpenoid that acts as an LXRα activator, demonstrating significant anti-inflammatory properties. Isolated from Taraxacum mongolicum, this compound has potential applications in the study of immune-inflammatory diseases, contributing to our understanding of metabolic regulation and inflammatory pathways. Researchers exploring therapeutic strategies for inflammatory conditions may find Taraxasterol an invaluable tool for investigation.

    In stock View Details
    5 mg
    $55.00
    10 mg
    $90.00
    All 2 sizes
  • 24-Hydroxycholesterol
    Cat. No.
    A67064
    CAS No.
    30271-38-6

    24-Hydroxycholesterol

    24-Hydroxycholesterol is a natural sterol that acts as a potent activator of liver X receptors (LXR). It enhances LXR-mediated gene expression, influencing lipid metabolism and cholesterol homeostasis. This compound is commonly utilized in research investigating neuroprotection, cholesterol regulation, and the modulation of NMDA receptor activity.

    In stock View Details
    1 mg
    $105.00
    2 mg
    $110.00
    All 7 sizes
  • LXR agonist 1
    Cat. No.
    A76528
    CAS No.
    1779524-90-1

    LXR agonist 1

    LXR Agonist 1 is a potent activator of Liver X Receptors (LXR-α and LXR-β), demonstrating AC50 values of 1.5 nM and 12 nM, respectively. This compound is valuable for investigating mechanisms related to lipid metabolism and atherosclerosis. Its ability to activate LXR pathways makes it a significant tool for research focused on cardiovascular diseases and related metabolic disorders.

    In stock View Details
    5 mg
    $470.00
    10 mg
    $775.00
    All 5 sizes
  • 25(S)-27-Hydroxy cholesterol
    Cat. No.
    A76545
    CAS No.
    56845-83-1

    25(S)-27-Hydroxy cholesterol

    25(S)-27-Hydroxy cholesterol is an LXR (liver X receptor) activator derived from CYP27A1-mediated cholesterol hydroxylation. This compound is known to inhibit the proliferation of melanoma cells, making it a valuable reagent for studies investigating cholesterol metabolism and its role in cancer biology. Additionally, its modulation of LXR activity presents opportunities for research into metabolic disorders and related therapeutic avenues.

    In stock View Details
    1 mg
    $180.00
    5 mg
    $555.00
    All 3 sizes

4 Items

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