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Lactate Dehydrogenase A (LDHA)

Lactate dehydrogenase A (LDHA) inhibitors block the enzyme that turns pyruvate into lactate. The reaction regenerates oxidized nicotinamide adenine dinucleotide (NAD+), so glycolysis can continue when mitochondrial oxidation is limited. Many tumor cells rely on this step for aerobic glycolysis, also called the Warburg effect. In 2006, lowering LDHA expression in tumor cells raised mitochondrial respiration and impaired tumor growth. FX-11 was reported in 2010 to induce oxidative stress and slow the growth of lymphoma and pancreatic cancer xenografts. GSK2837808A is a further LDHA inhibitor, and GNE-140 is listed as GNE-140 racemate and as (R)-GNE-140 and (S)-GNE-140. Sodium oxamate, a classic substrate analog, competes with pyruvate at several lactate dehydrogenase isoforms.

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  • 4-(Dimethylamino)phenol
    Cat. No.
    B18108
    CAS No.
    619-60-3

    4-(Dimethylamino)phenol

    4-(Dimethylamino)phenol acts as a lactate dehydrogenase (LDH) activator, enhancing extracellular LDH levels without significantly impacting gluconeogenesis. This compound serves as a potent cyanide antidote, facilitating metabolic pathways under certain conditions. Its toxicity arises from the reaction with glutathione, resulting in the formation of covalent complexes that impair cellular function. This reagent is valuable for investigations into metabolic regulation and cellular responses to oxidative stress.

    In stock View Details
    500 mg
    $20.00
    1 g
    $25.00
    All 4 sizes

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