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Stearoyl-CoA Desaturase (SCD)

SCD inhibitors block stearoyl-CoA desaturase, the enzyme that makes monounsaturated fatty acids. Stearoyl-coenzyme A desaturase (SCD) inserts a cis double bond at the delta-9 position of palmitoyl-CoA and stearoyl-CoA. Its products, palmitoleate and oleate, are built into triglycerides, phospholipids and cholesteryl esters. In 2002, mice lacking SCD1 were shown to be protected against adiposity, which drew interest to the enzyme in metabolic research. A 2015 X-ray structure of mouse SCD1 showed how this membrane enzyme holds its acyl-CoA substrate. A939572, CAY10566 and XEN723 are SCD1 inhibitors, and MK-8245 was designed to act mainly in the liver. SC-26196 inhibits delta-6 desaturase instead, a related fatty acid desaturase.

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  • (10E,12Z)-Octadeca-10,12-dienoic acid
    Cat. No.
    A39935
    CAS No.
    2420-56-6

    (10E,12Z)-Octadeca-10,12-dienoic acid

    Synonyms: trans-10,cis-12 CLA2

    (10E,12Z)-Octadeca-10,12-dienoic acid is a potent PPARα activator that plays a critical role in regulating lipid metabolism and adipocyte differentiation. This compound has demonstrated various biological activities, including antioxidant and antitumor effects, alongside the induction of proinflammatory cytokines and chemokines, which may contribute to decreased adipogenesis and insulin resistance. (10E,12Z)-Octadeca-10,12-dienoic acid also influences milk fat synthesis by reducing the expression of lipogenic enzymes and inhibiting fatty acid desaturation. Additionally, it has been shown to modulate lipoprotein lipase activity in cultured adipocytes and alter hepatic stearoyl-CoA desaturase expression in vivo.

    In stock View Details
    25 mg
    $400.00
    All 1 sizes

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