Mitochondrial Metabolism | Adooq Bioscience

Cat. No.: A11928

CAS No.: 1005342-46-0

LCL-161

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.

In stock View Details

2 mg

$55.00

5 mg

$75.00

All 7 sizes

Cat. No.: A39088

CAS No.: 3036751-71-7

ClpP activator-2

ClpP activator-2, or Compound GU18, acts as a specific activator of human ClpP (HsClpP), exhibiting a binding affinity with a Kd of 5.01 μM. This compound enhances the proteolytic function of HsClpP, effectively promoting the degradation of α-casein with an EC50 of 1.09 μM. Additionally, ClpP activator-2 induces mitochondrial reactive oxygen species (ROS) accumulation, resulting in mitochondrial damage and dysfunction. It demonstrates notable anti-multiple myeloma properties in vivo, making it a valuable tool for cancer research and studies targeting mitochondrial dynamics.

View Details

Out of stock

All 3 sizes

Cat. No.: A54490

CAS No.: 3087033-83-5

HsClpP activator-1

HsClpP activator-1 is a potent activator of HsClpP, exhibiting an EC50 of 0.22 μM. This compound demonstrates significant biological activity by effectively inhibiting cancer cell growth, with IC50 values ranging from 0.1 to 1 μM. HsClpP activator-1 serves as a valuable tool in cancer research and therapeutic development by modulating protein degradation pathways.

View Details

Out of stock

All 3 sizes

Cat. No.: A65925

CAS No.: 2411852-67-8

ZW290

ZW290 is a selective UCP1 activator that enhances the thermogenic function of brown adipose tissue (BAT). This compound promotes the expression of uncoupling protein 1 (UCP1) and inhibits ATP synthesis, thereby facilitating increased energy expenditure. ZW290 is valuable for research applications focused on metabolism, obesity, and therapeutic strategies targeting energy balance.

In stock View Details

All 4 sizes

Cat. No.: A76692

CAS No.: 3031789-26-8

ZK53

ZK53 is a selective activator of human caseinolytic protease P (HsClpP), exhibiting an EC50 of 1.37 µM for alpha-casein hydrolysis. The compound specifically enhances HsClpP activity without affecting bacterial ClpP proteins. In vitro studies demonstrate that ZK53 promotes apoptosis in lung squamous cell carcinoma (LUSC) cell lines, such as H1703, H520, and SK-MES-1, and disrupts mitochondrial functions. Additionally, ZK53 has been shown to inhibit tumor growth in the H1703 xenograft mouse model, making it a valuable tool for cancer research.

In stock View Details

1 mg

$35.00

5 mg

$85.00

All 6 sizes

Cat. No.: A76775

CAS No.: 76901-59-2

Speract

Speract is a peptide derived from sea urchin eggs that acts as a mitochondrial metabolism activator. It enhances sperm motility by stimulating mitochondrial activity, thereby promoting energy production essential for sperm function. This compound is useful in reproductive biology research, enabling studies on sperm physiology and the biochemical pathways regulating motility.

In stock View Details

All 4 sizes