Nucleoside Antimetabolite/Analog

Cat. No.

A56567

CAS No.

65199-10-2

Nitrobenzylthioinosine 5'-monophosphate

Synonyms: NBMPR-P

Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P) is a prodrug of the effective nucleoside transport inhibitor Nitrobenzylthioinosine (NBMPR). This compound primarily functions by blocking nucleoside transport in vivo, thereby mitigating host toxicity during high-dose Tubercidin treatment in tumor-bearing mice. NBMPR-P is valuable in research applications focusing on nucleoside transport mechanisms and related therapeutic interventions.

Cat. No.

A56569

CAS No.

205379-91-5

5'-dUMPS

5'-dUMPS is a competitive inhibitor of enzymes interacting with 2'-deoxypyrimidine-5'-monophosphate. It plays a crucial role in modulating nucleic acid synthesis and can be utilized in research focused on metabolic pathways and enzyme kinetics. Its capacity to regulate enzyme activity makes it a valuable tool for studies in molecular biology and pharmacology.

Cat. No.

A56605

CAS No.

103078-56-4

7-CH-5'-dAMP

Synonyms: 5'-dTuMP

7-CH-5'-dAMP, an adenosine derivative, serves as a potential substrate and competitive inhibitor for enzymes interacting with 2-deoxyadenosine-5-monophosphate. This compound is valuable in studying enzyme kinetics and mechanisms, particularly in the context of nucleotide metabolism and phosphotransfer reactions. Its modulation of enzymatic activity makes it a useful tool for exploring biological pathways involving adenine nucleotides.

Cat. No.

A65010

CAS No.

3099108-75-2

RGB097

RGB097 is a potent inhibitor of D-dopachrome tautomerase (D-DT), demonstrating an IC50 value of 0.5 µM. This compound exhibits significant biological activity and has potential applications in cancer research, particularly in elucidating the role of D-DT in oncogenesis and tumor progression.

Cat. No.

A65011

CAS No.

2582755-31-3

MIF-IN-5

MIF-IN-5 is a potent and reversible inhibitor of macrophage migration inhibitory factor (MIF), exhibiting a competitive mechanism of action. With an IC50 of 4.8 μM and a Ki value of 3.3 μM, it effectively disrupts MIF's biological activity. This compound is valuable for research applications involving inflammation, immune response modulation, and potential therapeutic strategies targeting various diseases associated with MIF dysregulation.

Cat. No.

A65012

CAS No.

696643-14-8

HTS05585

HTS05585 is a selective inhibitor of macrophage migration inhibitory factor (MIF), demonstrating a Kd value of 0.29 μM via microscale thermophoresis and 0.32±0.01 μM confirmed by isothermal titration calorimetry. This compound effectively inhibits the release of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, from LPS-stimulated macrophages. HTS05585 is a valuable tool for studying inflammation-related diseases, particularly in the context of sepsis research.

Cat. No.

A65013

CAS No.

160488-11-9

TE-11

TE-11 is a potent MIF tautomerase inhibitor, exhibiting an IC50 value of 5.63 μM. This compound effectively ameliorates CD-like colitis and reduces migration of MIF-induced eosinophils and neutrophils. Additionally, TE-11 prevents M1 polarization and the associated metabolic reprogramming, making it a valuable tool for research in inflammatory and autoimmune disorders.

Cat. No.

A71326

CAS No.

103301-73-1

GDP-D-mannose disodium

GDP-D-mannose disodium is a GTP inhibitor that serves as a crucial donor substrate for mannosyltransferases. Comprising GDP-α-D-mannose and GDP-β-D-mannose, this compound demonstrates competitive inhibition towards GTP with a Ki value of 14.7 μM, and an uncompetitive inhibition against mannose-1-phosphate with a Ki of 115 μM. It is employed in research applications aimed at elucidating glycosylation processes and studying glycan biosynthesis.

Cat. No.

A71434

CAS No.

548486-59-5

Ulodesine

Synonyms: BCX4208

Ulodesine is a potent purine nucleoside phosphorylase (PNP) inhibitor, exhibiting an IC50 value of 2.293 nM. This compound is valuable for research into hypouricemia, as it effectively modulates purine metabolism. Its specific inhibition of PNP provides a useful tool for understanding the biochemical pathways involved in nucleotide degradation and associated metabolic disorders.

Cat. No.

A72263

CAS No.

148296-46-2

GDP-α-D-mannose disodium

GDP-α-D-mannose disodium serves as a GTP inhibitor, acting as a donor substrate for mannosyltransferases and a precursor for GDP-β-L-fucose. It exhibits competitive inhibition towards GTP, with a Ki value of 14.7 μM, and demonstrates uncompetitive inhibition with respect to mannose-1-phosphate, showing a Ki of 115 μM. This compound is valuable for investigations into glycosylation processes and the role of GTP in various cellular mechanisms.